DNA–dependent protein kinase in telomere maintenance and protection

Tumor Cell–Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation

(2018) Miaomiao Zhang et al.   Dose-Response

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

(2018) Yu-Fen Lin et al.   NUCLEIC ACIDS RESEARCH

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Emerging roles of hnRNPA1 in modulating malignant transformation

(2017) Rajat Roy et al.   Wiley Interdisciplinary Reviews-RNA

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A balance between elongation and trimming regulates telomere stability in stem cells

(2016) Teresa Rivera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops

(2016) Rika Kusumoto-Matsuo et al.   Aging-US

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication

(2015) Jiangdong Sui et al.   NUCLEIC ACIDS RESEARCH

Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection

(2015) S Zhang et al.   ONCOGENE

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

(2015) Nicholas Jette et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Transcriptional elongation requires DNA break-induced signalling

(2015) Heeyoun Bunch et al.   Nature Communications

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae

(2015) Evan P Hass et al.   eLife

DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres

(2014) Prabhat Khadka et al.   BIOCHEMICAL JOURNAL

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

(2014) Q. Deng et al.   JOURNAL OF NEUROSCIENCE

Targeting DNA-PKcs and telomerase in brain tumour cells

(2014) Resham Gurung et al.   Molecular Cancer

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

(2014) Yu-Fen Lin et al.   NUCLEIC ACIDS RESEARCH

53BP1 Mediates the Fusion of Mammalian Telomeres Rendered Dysfunctional by DNA-PKcs Loss or Inhibition

(2014) Ivana Rybanska-Spaeder et al.   PLoS One

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

(2013) Kentaro Takahama et al.   CHEMISTRY & BIOLOGY

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

(2013) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

(2013) Xin Zhou et al.   PLoS One

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres

(2013) Phuong N. Le et al.   Frontiers in Oncology

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model

(2012) Jennifer S. Pfingsten et al.   CELL

Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

(2012) T. T. Chow et al.   GENES & DEVELOPMENT

Normal mammalian cells negatively regulate telomere length by telomere trimming

(2011) H. A. Pickett et al.   HUMAN MOLECULAR GENETICS

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

(2011) Kyung-Jong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

(2011) Shichuan Zhang et al.   JOURNAL OF CELL BIOLOGY

RecQ helicases in DNA double strand break repair and telomere maintenance

(2011) Dharmendra Kumar Singh et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

TRF2/RAP1 and DNA–PK mediate a double protection against joining at telomeric ends

(2010) Oriane Bombarde et al.   EMBO JOURNAL

SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair

(2010) Yung C Lam et al.   EMBO JOURNAL

Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level

(2010) A. C. Krüger et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Recent progress in dyskeratosis congenita

(2010) Nobuhiro Nishio et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways

(2010) A. Porro et al.   MOLECULAR AND CELLULAR BIOLOGY

Apollo Contributes to G Overhang Maintenance and Protects Leading-End Telomeres

(2010) Peng Wu et al.   MOLECULAR CELL

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Cancer in dyskeratosis congenita

(2009) B. P. Alter et al.   BLOOD

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

(2009) Yong Zhao et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1

(2009) N. S. Y. Ting et al.   NUCLEIC ACIDS RESEARCH

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis of Thirty-two Double-Strand DNA Break Repair Genes in Breast and Pancreatic Cancers

(2008) X. Wang et al.   CANCER RESEARCH

Mutations to Ku reveal differences in human somatic cell lines

(2008) Kazi R. Fattah et al.   DNA REPAIR

TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

(2008) Franck Gallardo et al.   EMBO JOURNAL

Functional Dissection of Human and Mouse POT1 Proteins

(2008) W. Palm et al.   MOLECULAR AND CELLULAR BIOLOGY