The hypoxic microenvironment: a driving force for heterotopic ossification progression

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?

(2019) Jianhui Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Impact of different methods of induction of cellular hypoxia: focus on protein homeostasis signaling pathways and morphology of C2C12 skeletal muscle cells differentiated into myotubes

(2019) Samir Bensaid et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells

(2019) Geneviève Drouin et al.   Skeletal Muscle

Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

(2018) Guorong Lu et al.   BONE

Heterotopic ossification: Mechanistic insights and clinical challenges

(2018) Ruoshi Xu et al.   BONE

Acute and chronic rapamycin use in patients with Fibrodysplasia Ossificans Progressiva: A report of two cases

(2018) Frederick S. Kaplan et al.   BONE

Is heterotopic ossification getting nervous?: The role of the peripheral nervous system in heterotopic ossification

(2018) Eleanor L. Davis et al.   BONE

Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP)

(2018) Haitao Wang et al.   BONE

In Vitro Anticoagulant Activity and Active Components of Safflower Injection

(2018) Kai-Hong Wang et al.   MOLECULES

Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis

(2018) Ran Ma et al.   Journal of Orthopaedic Surgery and Research

IL-1β-Mediated Up-Regulation of WT1D via miR-144-3p and Their Synergistic Effect with NF-κB/COX-2/HIF-1α Pathway on Cell Proliferation in LUAD

(2018) Chen Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents

(2018) Shumaila Tasneem et al.   PHARMACOLOGICAL RESEARCH

The ethnopharmacology, phytochemistry and pharmacology of Angelica biserrata – A review

(2018) Jiahua Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

(2017) Koichi Murata et al.   IMMUNITY

Hypoxia-inducible-factor-1 in trauma and critical care

(2017) Dorian A. Bogdanovski et al.   JOURNAL OF CRITICAL CARE

Endocrine targets of hypoxia-inducible factors

(2017) Hsiu-Chi Lee et al.   JOURNAL OF ENDOCRINOLOGY

Hypoxia and HIF-1 activation in bacterial infections

(2017) Gayatri Devraj et al.   MICROBES AND INFECTION

The traumatic bone: trauma-induced heterotopic ossification

(2017) Devaveena Dey et al.   Translational Research

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss

(2016) S. Saad et al.   Acta Biomaterialia

Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

(2016) Haitao Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of HIF in immunity and inflammation

(2016) Eoin P. Cummins et al.   MOLECULAR ASPECTS OF MEDICINE

Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK

(2016) J.E. Lafont et al.   OSTEOARTHRITIS AND CARTILAGE

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

(2016) D. Dey et al.   Science Translational Medicine

Bone Morphogenetic Proteins

(2016) Takenobu Katagiri et al.   Cold Spring Harbor Perspectives in Biology

The impact of hypoxia on mesenchymal progenitor cells of human skeletal tissue in the pathogenesis of heterotopic ossification

(2015) Sebastian Winkler et al.   INTERNATIONAL ORTHOPAEDICS

Suppression of the proliferation of hypoxia-Induced retinal pigment epithelial cell by rapamycin through the /mTOR/HIF-1α/VEGF/ signaling

(2015) Ning-Ning Liu et al.   IUBMB LIFE

Heterotopic Ossification

(2015) Kavitha Ranganathan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice

(2015) Naoyuki Kawao et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease

(2015) Gina A. Smith et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The role of leptin in regulating bone metabolism

(2015) Jagriti Upadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

(2015) M M Olcina et al.   ONCOGENE

Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification

(2015) Shailesh Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer

(2015) Chen Zhao et al.   PLoS Computational Biology

The Immunological Contribution to Heterotopic Ossification Disorders

(2015) Michael R. Convente et al.   Current Osteoporosis Reports

Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing

(2014) Rahul Agrawal et al.   BMC GENOMICS

Hypoxia-regulated gene network in drug resistance and cancer progression

(2014) Shao-Chieh Lin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Association between alendronate, serum alkaline phosphatase level, and heterotopic ossification in individuals with spinal cord injury

(2014) Avraam Ploumis et al.   JOURNAL OF SPINAL CORD MEDICINE

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

(2014) Adam M Fontebasso et al.   NATURE GENETICS

Heterotopic ossification: a systematic review

(2014) Dafydd S Edwards et al.   Journal of the Royal Army Medical Corps

Burn Injury Enhances Bone Formation in Heterotopic Ossification Model

(2013) Jonathan R. Peterson et al.   ANNALS OF SURGERY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Muscle blood flow, hypoxia, and hypoperfusion

(2013) Michael J. Joyner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

BMP-9 expression in human traumatic heterotopic ossification: a case report

(2013) Guillaume Grenier et al.   Skeletal Muscle

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea

(2012) I. Almendros et al.   EUROPEAN RESPIRATORY JOURNAL

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

(2012) Nanduri R. Prabhakar et al.   PHYSIOLOGICAL REVIEWS

Vasculogenic Mimicry of HT1080 Tumour Cells In Vivo: Critical Role of HIF-1α-Neuropilin-1 Axis

(2012) Roli M. Misra et al.   PLoS One

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas

(2011) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia

(2011) Paula Kolar et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Signal transduction in vasculogenesis and developmental angiogenesis

(2011) Sunita Patel-Hett et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Synergistic Inhibition of Endochondral Bone Formation by Silencing Hif1α and Runx2 in Trauma-induced Heterotopic Ossification

(2011) Lin Lin et al.   MOLECULAR THERAPY

The bone morphogenetic protein antagonist noggin protects white matter after perinatal hypoxia–ischemia

(2011) Maria L.V. Dizon et al.   NEUROBIOLOGY OF DISEASE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

(2011) Erinn B. Rankin et al.   Current Osteoporosis Reports

Hypoxia, HIFs and bone development

(2010) Elisa Araldi et al.   BONE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

(2010) N. Ortega et al.   Disease Models & Mechanisms

BMP-9-induced muscle heterotopic ossification requires changes to the skeletal muscle microenvironment

(2010) Elisabeth Leblanc et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL

(2010) Mingqing Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inherited human diseases of heterotopic bone formation

(2010) Eileen M. Shore et al.   Nature Reviews Rheumatology

Heterotopic ossification induced by Achilles tenotomy via endochondral bone formation: Expression of bone and cartilage related genes

(2009) Lin Lin et al.   BONE

Hypoxic “second hit” in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibition

(2009) Elizabeth A. Sailhamer et al.   CYTOKINE

Recent advances in BMP receptor signaling

(2009) Christina Sieber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Selective COX-2 inhibitor versus nonselective COX-1 and COX-2 inhibitor in the prevention of heterotopic ossification after total hip arthroplasty: a meta-analysis of randomised trials

(2009) Deting Xue et al.   INTERNATIONAL ORTHOPAEDICS

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Ectopic osteogenesis of mouse bone marrow stromal cells transfected with BMP 2/VEGF165genesin vivo

(2009) Xiao-bin Tian et al.   Orthopaedic Surgery

Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling

(2008) Kimberly A Jacobsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Free radical scavengers versus methylprednisolone in the prevention of experimentally induced heterotopic ossification

(2008) Luc C. Vanden Bossche et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS