Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification

Prospective heterotopic ossification progenitors in adult human skeletal muscle

(2015) Jennifer Downey et al.   BONE

What Risk Factors Predict Recurrence of Heterotopic Ossification After Excision in Combat-related Amputations?

(2015) Gabriel J. Pavey et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints

(2015) Shailesh Agarwal et al.   DEVELOPMENTAL BIOLOGY

Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α

(2015) Kyle L. Flannigan et al.   FASEB JOURNAL

Risk factors for the development of heterotopic ossification in seriously burned adults

(2015) Benjamin Levi et al.   Journal of Trauma and Acute Care Surgery

Risk factors for the development of heterotopic ossification in seriously burned adults

(2015) Benjamin Levi et al.   Journal of Trauma and Acute Care Surgery

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Treatment of heterotopic ossification through remote ATP hydrolysis

(2014) J. R. Peterson et al.   Science Translational Medicine

Tendon Progenitor Cells in Injured Tendons Have Strong Chondrogenic Potential: The CD105-Negative Subpopulation Induces Chondrogenic Degeneration

(2014) Shuji Asai et al.   STEM CELLS

Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle

(2014) A Uezumi et al.   Cell Death & Disease

Burn Injury Enhances Bone Formation in Heterotopic Ossification Model

(2013) Jonathan R. Peterson et al.   ANNALS OF SURGERY

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Retinoic Acid Signalling Is Activated in the Postischemic Heart and May Influence Remodelling

(2012) Dusan Bilbija et al.   PLoS One

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

(2011) Kyeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Synergistic Inhibition of Endochondral Bone Formation by Silencing Hif1α and Runx2 in Trauma-induced Heterotopic Ossification

(2011) Lin Lin et al.   MOLECULAR THERAPY

Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study

(2011) Keyur H. Desai et al.   PLOS MEDICINE

Treatment with HIF-1α Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice

(2010) Jörg J. Jacoby et al.   Journal of Thoracic Oncology

Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer

(2010) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Identification and Interpretation of Longitudinal Gene Expression Changes in Trauma

(2010) Natasa Rajicic et al.   PLoS One

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

(2009) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA