3D structure of the transporter ABCG2—What's new?

Challenges and opportunities in cryo-EM single-particle analysis

(2019) Dmitry Lyumkis   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1

(2018) Zachary Lee Johnson et al.   CELL

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2

(2018) Anne Ripperger et al.   Frontiers in Pharmacology

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

(2018) Niall Heyes et al.   DRUG METABOLISM AND DISPOSITION

Single-particle cryo-EM—How did it get here and where will it go

(2018) Yifan Cheng   SCIENCE

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

(2018) Jack Wright et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ABCG2: does resolving its structure elucidate the mechanism?

(2018) Parth Kapoor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

ABC Transport Proteins in Cardiovascular Disease—A Brief Summary

(2017) Toni Schumacher et al.   MOLECULES

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies

(2017) Ricardo J. Ferreira et al.   Scientific Reports

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

The C421A (Q141K) polymorphism enhances the 3′-untranslated region (3′-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2

(2016) Anne Ripperger et al.   BIOCHEMICAL PHARMACOLOGY

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques

(2016) Kelvin Wong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter

(2016) Laura László et al.   PLoS One

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate

(2015) Diluk R W Kannangara et al.   ANNALS OF THE RHEUMATIC DISEASES

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

(2015) S. Macalou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation

(2015) Mark F. Rosenberg et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning, expression, and functional analysis of molecular motor pilT and pilU genes of type IV pili in Acidithiobacillus ferrooxidans

(2012) Yongquan Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes

(2010) Manuela Dezi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters

(2010) J. Weiss et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Telmisartan: a review of its pharmacodynamic and pharmacokinetic properties

(2010) Sylvia Deppe et al.   Expert Opinion on Drug Metabolism & Toxicology

ABCG2 Transports and Transfers Heme to Albumin through Its Large Extracellular Loop

(2010) Elodie Desuzinges-Mandon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2

(2009) Hiroshi Nakagawa et al.   FEBS Journal

Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-Cell lymphoma

(2009) Ji Eun Kim et al.   MODERN PATHOLOGY

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

(2008) Christopher A. McDevitt et al.   FEBS Journal

Effect of Cysteine Mutagenesis on the Function and Disulfide Bond Formation of Human ABCG2

(2008) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

BCRP/ABCG2 in the Placenta: Expression, Function and Regulation

(2008) Qingcheng Mao   PHARMACEUTICAL RESEARCH

Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

(2008) Tomoka Furukawa et al.   PHARMACEUTICAL RESEARCH