Article
Biochemistry & Molecular Biology
Yilong Zhao, Huajun Yang, Wei Shan, Anchen Guo, Qun Wang
Summary: Moderate ethanol preconditioning protects against ischemic brain injury by upregulating the expression of BKCa channels in rats.
NEUROCHEMICAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Physiology
Thijs R. J. Landman, Laween Uthman, Inge A. H. Hofmans, Yvonne Schoon, Frank-Erik de Leeuw, Dick H. J. Thijssen
Summary: This study compared the effects of handgrip exercise and remote ischemic preconditioning on inflammatory biomarkers in patients with cerebral small vessel disease. The results showed that both single and repeated handgrip exercise and remote ischemic preconditioning immediately reduced inflammatory markers in cSVD patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eva Baranovicova, Petra Hnilicova, Dagmar Kalenska, Peter Kaplan, Maria Kovalska, Zuzana Tatarkova, Anna Tomascova, Jan Lehotsky
Summary: H-1 NMR metabolomics is a valuable tool for characterizing the distribution and alterations of metabolites induced by cerebral ischemic injury or its combination with hyperhomocysteinemia. The study found decreased neurotransmitter pool and increased tissue glutamine level in the brain tissue after ischemic injury. Metabolomic alterations were observed in the blood plasma, including decreased glycolytic intermediates and increased plasma ketone bodies. Ischemic preconditioning showed a lower extent of metabolomic changes. In hyperhomocysteinemic models, a decrease in several amino acids in plasma was associated with hippocampal neuropathology.
Article
Clinical Neurology
Xia Liu, Qinlian Ye, Zhengzheng Huang, Xiuping Li, Liping Zhang, Xuan Liu, Yun-Cheng Wu, Ulf Brockmeier, Dirk M. Hermann, Ya-Chao Wang, Lijie Ren
Summary: In this study, a switch from UPS to autophagy due to changes in BAG3 expression was observed in cerebral ischemia. BAG3 overexpression activated autophagy and inhibited apoptosis, leading to improved neurological function and reduced ischemic injury.
Article
Multidisciplinary Sciences
Hye Youn Sung, Eun Nam Choi, Jihye Han, Yun Ju Chae, Sun-Wha Im, Hee-Sun Kim, Eun-Mi Park, Jung-Hyuck Ahn
Summary: Research suggests that ischemic preconditioning reduces brain ischemia-reperfusion injury by downregulating the expression of miR-33-5p and miR-135b-5p, which in turn protects neurons from apoptosis induced by oxygen-glucose deprivation. Inhibition of these two miRNAs significantly increases mRNA and protein levels of ABCA1 and reduces activation of the mitochondria-dependent apoptosis pathway.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yunwei Shi, Xinyi Chen, Jiaxing Liu, Xingjuan Fan, Ying Jin, Jingxiao Gu, Jiale Liang, Xinmiao Liang, Caiping Wang
Summary: Isoquercetin has been identified as a neuroprotective agent against ischemic stroke, showing the potential to suppress inflammatory response and improve cell recovery in rats with cerebral ischemia/reperfusion injury. The study suggests that targeting the TLR4 and C5aR1-mediated cAMP/PKA/I-kappa B/NF-kappa B signaling pathway may provide a promising therapeutic strategy for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Moscarelli, Gianni D. Angelini, Costanza Emanueli, Saadeh Suleiman, Martino Pepe, Gaetano Contegiacomo, Prakash P. Punjabi
Summary: The study, based on multiple studies, confirmed the cardioprotective effect of RIPC on patients undergoing valve intervention, but did not observe improvement in post-operative clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Hao Zhou, Lin Li, Hao Sun, Hua Li, Yuxuan Wu, Xiaomin Zhang, Jinsong Zhang
Summary: The study demonstrates that remote ischemic preconditioning can alleviate secondary liver injury following hemorrhagic shock by activating autophagy, improving blood pressure adaptability, reducing lactate and aminotransferase levels, delaying the decrease in liver density, attenuating inflammatory response and apoptosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Plant Sciences
Antony Justin, Peet Thomas, Gaddam Narasimha Rao, Jeyaram Bharathi Jeyabalan, Chintha Narendar, Sivasankaran Ponnusankar, Jubie Selvaraj, R. Hariprasad
Summary: The study chemically standardized Chandamarutha Chenduram (CC) and found its neuroprotective effect in cerebral ischemia, regulating neurotransmitters, antioxidant enzymes, and inflammatory cytokines to mitigate excitotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Yang Deng, Rui Duan, Wangli Ding, Qiuchen Gu, Manman Liu, Junshan Zhou, Jianguo Sun, Junrong Zhu
Summary: In this study, it was found that exosomes derived from oxygen-glucose-deprivation/reoxygenation-stimulated astrocytes (OGD/R-ADEXs) reduced neuronal death and promoted autophagy by targeting AMPK/mTOR signaling. The enzyme Nampt released by OGD/R-ADEXs played a vital role in regulating autophagy and ameliorating acute ischemic stroke.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Annika Raupach, Katharina Feige, Christian Reiter, Timo Brandenburger, Nicole Heinen, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The study found that RIPC did not induce the phosphorylation of AKT or STAT5 in a rat model, nor did it modulate the activation of AKT and STAT5 following I/R, suggesting that RIPC-induced cardioprotection may not be mediated by the activation of AKT or STAT5 at the investigated time points.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Physiology
Yanlong Ren, Shujin Lin, Wenxian Liu, Huiguo Ding
Summary: This study investigated the cardioprotective effects of hepatic remote preconditioning against injury induced by ischemia/reperfusion, showing that hepatic RIPC can reduce infarct size, improve left ventricular pressure and mechanical activity, as well as decrease the release of phosphocreatine kinase-myocardial band and lactate dehydrogenase.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.