Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomization Study of ACLY and Cardiovascular Disease

(2019) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

WMH and long-term outcomes in ischemic stroke

(2019) Marios K. Georgakis et al.   NEUROLOGY

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

(2019) Luanluan Sun et al.   NATURE MEDICINE

Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events

(2019) Jane Armitage et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

(2019) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Small vessel disease: mechanisms and clinical implications

(2019) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Vascular Cognitive Impairment and Dementia

(2019) Costantino Iadecola et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of LDL Cholesterol on Microvascular Versus Macrovascular Disease

(2019) Frida Emanuelsson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CETP inhibition and HDL: what is the trial REVEALing?

(2018) Lina Badimon   CARDIOVASCULAR RESEARCH

Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke

(2018) Michael V. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank

(2018) Fidel Alfaro-Almagro et al.   NEUROIMAGE

Sex differences in associations between blood lipids and cerebral small vessel disease

(2018) Z.-G. Yin et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes

(2018) George Hindy et al.   STROKE

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia

(2018) Loes C.A. Rutten-Jacobs et al.   STROKE

Causal associations between risk factors and common diseases inferred from GWAS summary data

(2018) Zhihong Zhu et al.   Nature Communications

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm

(2018) Seamus C. Harrison et al.   JAMA Cardiology

The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women

(2018) Rowa Aljondi et al.   Brain Imaging and Behavior

Impact of Lipids on Cardiovascular Health

(2018) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Mendelian randomization study of the effects of blood lipids on breast cancer risk

(2018) Christoph Nowak et al.   Nature Communications

Genome-wide meta-analysis identifies 3 novel loci associated with stroke

(2018) Rainer Malik et al.   ANNALS OF NEUROLOGY

Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile

(2018) Lisanne L. Blauw et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury

(2018) Stéphanie Debette et al.   JAMA Neurology

Opportunities and Challenges in Mendelian Randomization Studies to Guide Trial Design

(2018) Christopher J. O’Donnell et al.   JAMA Cardiology

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

(2017) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

(2017) Michael V. Holmes et al.   Nature Reviews Cardiology

Genetics of coronary artery disease: discovery, biology and clinical translation

(2017) Amit V. Khera et al.   NATURE REVIEWS GENETICS

CETP Inhibitors — A New Inning?

(2017) Robert A. Hegele   NEW ENGLAND JOURNAL OF MEDICINE

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

(2017) A. Michael Lincoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1

(2017) Karen Y. Fung et al.   Frontiers in Physiology

Genetic variants inCETPincrease risk of intracerebral hemorrhage

(2016) Christopher D. Anderson et al.   ANNALS OF NEUROLOGY

Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle ConcentrationNovelty and Significance

(2016) Jeffrey S. Monette et al.   CIRCULATION RESEARCH

Statins for Prevention of Cardiovascular Disease in Adults

(2016) Roger Chou et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interpretation of the evidence for the efficacy and safety of statin therapy

(2016) Rory Collins et al.   LANCET

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

(2016) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging Risk Factors for Stroke

(2016) Jemma C. Hopewell et al.   STROKE

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

Association of Lipid Fractions With Risks for Coronary Artery Disease and Diabetes

(2016) Jon White et al.   JAMA Cardiology

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of 3 Population-Based Cohorts

(2015) P. Wurtz et al.   CIRCULATION

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

(2015) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both

(2015) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular dementia

(2015) John T O'Brien et al.   LANCET

The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study

(2015) Naohisa Hosomi et al.   EBioMedicine

Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

(2014) Daniel Woo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian randomization of blood lipids for coronary heart disease

(2014) Michael V. Holmes et al.   EUROPEAN HEART JOURNAL

HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the lipoprotein investigators collaborative

(2014) S. S. Martin et al.   EUROPEAN HEART JOURNAL

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome

(2014) S. Burgess   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

(2014) Walter N. Kernan et al.   STROKE

High-density lipoprotein subfractions: current views and clinical practice applications

(2014) Seth S. Martin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association of high-density lipoprotein subclasses and incident coronary heart disease: The Jackson Heart and Framingham Offspring Cohort Studies

(2014) Parag H Joshi et al.   European Journal of Preventive Cardiology

HDL and endothelial protection

(2013) A Tran-Dinh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates

(2013) Amy E. Taylor et al.   Economics & Human Biology

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Cholesterol Levels and Risk of Hemorrhagic Stroke

(2013) Xiang Wang et al.   STROKE

The role of cholesterol efflux in mechanisms of endothelial protection by HDL

(2012) Hamish C. Prosser et al.   CURRENT OPINION IN LIPIDOLOGY

High-density lipoprotein subclasses and their relationship to cardiovascular disease

(2012) H. Robert Superko et al.   Journal of Clinical Lipidology

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Low High-Density Lipoprotein 3 Reduces the Odds of Men Surviving to Age 85 During 53-Year Follow-Up

(2012) Paul T. Williams   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Risk factors for intracerebral hemorrhage differ according to hemorrhage location

(2012) S. R. Martini et al.   NEUROLOGY

Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

(2012) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Using multiple genetic variants as instrumental variables for modifiable risk factors

(2011) Tom M Palmer et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities

(2010) Anatol Kontush et al.   CURRENT OPINION IN LIPIDOLOGY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Protective Effect of High-Density Lipoprotein-Based Therapy in a Model of Embolic Stroke

(2010) Bertrand Lapergue et al.   STROKE

Reconstituted High-Density Lipoprotein Attenuates Platelet Function in Individuals With Type 2 Diabetes Mellitus by Promoting Cholesterol Efflux

(2009) Anna C. Calkin et al.   CIRCULATION

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

(2009) Sajoscha A. Sorrentino et al.   CIRCULATION

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention

(2009) Pierre Amarenco et al.   LANCET NEUROLOGY

High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response

(2008) Andrew J. Murphy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008

(2008)   CEREBROVASCULAR DISEASES

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE