Molecular Mechanisms of Pathologies of Skeletal and Cardiac Muscles Caused by Point Mutations in the Tropomyosin Genes

Moving beyond simple answers to complex disorders in sarcomeric cardiomyopathies: the role of integrated systems

(2019) Andrea E. Deranek et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding

(2019) Joanna Moraczewska et al.   FEBS Journal

The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12

(2019) Stanislava V. Avrova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation

(2019) Salwa Abdullah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

(2018) Gerrie P. Farman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Thermal unfolding of homodimers and heterodimers of different skeletal-muscle isoforms of tropomyosin

(2018) Alexander M. Matyushenko et al.   BIOPHYSICAL CHEMISTRY

Myopathic mutations in the β-chain of tropomyosin differently affect the structural and functional properties of ββ- and αβ-dimers

(2018) Sergey Y. Bershitsky et al.   FASEB JOURNAL

Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle

(2018) Balázs Kiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain

(2018) Alexander M. Matyushenko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies

(2018) Yurii Borovikov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

(2018) Thu Ly et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

(2017) Binnu Gangadharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene

(2017) Yurii S. Borovikov et al.   Scientific Reports

Tropomyosin-binding properties modulate competition between tropomodulin isoforms

(2016) Mert Colpan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin

(2016) Alexander M. Matyushenko et al.   BIOCHEMISTRY

Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle

(2016) Olga E. Karpicheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tropomyosin-Mediated Regulation of Cytoplasmic Myosins

(2016) Dietmar J. Manstein et al.   TRAFFIC

Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle

(2015) Yurii S. Borovikov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tropomyosin - master regulator of actin filament function in the cytoskeleton

(2015) P. W. Gunning et al.   JOURNAL OF CELL SCIENCE

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

(2015) Galina Schevzov et al.   MOLECULAR BIOLOGY OF THE CELL

Energy landscapes reveal the myopathic effects of tropomyosin mutations

(2014) Marek Orzechowski et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: A novel pathogenic mechanism for hypertrophic cardiomyopathy

(2014) Rachel K. Moore et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens

(2014) Benjamin J. Caldwell et al.   Cytoskeleton

Mutation Update and Genotype-Phenotype Correlations of Novel and Previously Described Mutations inTPM2andTPM3Causing Congenital Myopathies

(2014) Minttu Marttila et al.   HUMAN MUTATION

Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

(2014) Tejas M. Gupte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A systematic nomenclature for mammalian tropomyosin isoforms

(2014) Michael A. Geeves et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The myosin-activated thin filament regulatory state, M − -open: a link to hypertrophic cardiomyopathy (HCM)

(2014) Sherwin S. Lehrer et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Congenital myopathies with secondary neuromuscular transmission defects; A case report and review of the literature

(2014) Pedro M. Rodríguez Cruz et al.   NEUROMUSCULAR DISORDERS

Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations

(2014) Minttu Marttila et al.   Skeletal Muscle

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients

(2013) Steven Marston et al.   HUMAN MOLECULAR GENETICS

Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles

(2013) Sabahattin Bicer et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Skeletal muscle myopathy mutations at the actin tropomyosin interface that cause gain- or loss-of-function

(2013) Massimiliano Memo et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Alpha-tropomyosin mutations in inherited cardiomyopathies

(2013) Charles Redwood et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Polymorphism in tropomyosin structure and function

(2013) Miro Janco et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains

(2012) Miro Janco et al.   BIOCHEMISTRY

In Vitro Formation and Characterization of the Skeletal Muscle α·β Tropomyosin Heterodimers

(2012) Athanasia Kalyva et al.   BIOCHEMISTRY

Long-Range Effects of Familial Hypertrophic Cardiomyopathy Mutations E180G and D175N on the Properties of Tropomyosin

(2012) Socheata Ly et al.   BIOCHEMISTRY

Tropomyosin: Double helix from the protein world

(2012) I. A. Nevzorov et al.   BIOCHEMISTRY-MOSCOW

Functional effects of congenital myopathy-related mutations in gamma-tropomyosin gene

(2012) Katarzyna Robaszkiewicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Congenital myasthenic syndromes: Achievements and limitations of phenotype-guided gene-after-gene sequencing in diagnostic practice: A study of 680 patients

(2012) Angela Abicht et al.   HUMAN MUTATION

Mutations in TPM2 and congenital fibre type disproportion

(2012) Nigel F. Clarke et al.   NEUROMUSCULAR DISORDERS

Myopathies associated with β-tropomyosin mutations

(2012) H. Tajsharghi et al.   NEUROMUSCULAR DISORDERS

Tropomyosin Flexural Rigidity and Single Ca2+ Regulatory Unit Dynamics: Implications for Cooperative Regulation of Cardiac Muscle Contraction and Cardiomyocyte Hypertrophy

(2012) Campion K. P. Loong et al.   Frontiers in Physiology

Abnormal actin binding of aberrant β-tropomyosins is a molecular cause of muscle weakness inTPM2-related nemaline and cap myopathy

(2011) Minttu Marttila et al.   BIOCHEMICAL JOURNAL

Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy

(2011) Julien Ochala et al.   FASEB JOURNAL

Inherited Cardiomyopathies

(2011) Hugh Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Localization of the two tropomyosin-binding sites of troponin T

(2010) J.-P. Jin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The genetics of dilated cardiomyopathy

(2010) Lisa Dellefave et al.   CURRENT OPINION IN CARDIOLOGY

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation

(2010) Neal K. Lakdawala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

The coordination between actin filaments and adhesion in mesenchymal migration

(2010) Geraldine M. O'Neill   Cell Adhesion & Migration

Stability of two β-tropomyosin isoforms: effects of mutation Arg91Gly

(2009) Ilya Nevzorov et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Tropomyosin Isoform Expression Regulates the Transition of Adhesions To Determine Cell Speed and Direction

(2009) C. T. T. Bach et al.   MOLECULAR AND CELLULAR BIOLOGY

Thin filament proteins mutations associated with skeletal myopathies: Defective regulation of muscle contraction

(2008) Julien Ochala   JOURNAL OF MOLECULAR MEDICINE-JMM

Disease Severity and Thin Filament Regulation in M9RTPM3Nemaline Myopathy

(2008) Biljana Ilkovski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space

(2008) Peter Gunning et al.   PHYSIOLOGICAL REVIEWS

A tropomyosin 1 induced defect in cytokinesis can be rescued by elevated expression of cofilin

(2008) Julie A. I. Thoms et al.   CELL MOTILITY AND THE CYTOSKELETON

Tropomyosin 4 regulates adhesion structures and resorptive capacity in osteoclasts

(2007) Brooke K. McMichael et al.   EXPERIMENTAL CELL RESEARCH