Alpha-tropomyosin mutations in inherited cardiomyopathies

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy

(2012) Xiaochuan (Edward) Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains

(2012) Miro Janco et al.   BIOCHEMISTRY

Long-Range Effects of Familial Hypertrophic Cardiomyopathy Mutations E180G and D175N on the Properties of Tropomyosin

(2012) Socheata Ly et al.   BIOCHEMISTRY

A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding

(2012) Judith B.A. van de Meerakker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Myofilament Ca Sensitization Increases Cytosolic Ca Binding Affinity, Alters Intracellular Ca Homeostasis, and Causes Pause-Dependent Ca-Triggered Arrhythmia

(2012) Tilmann Schober et al.   CIRCULATION RESEARCH

Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin

(2012) Campion K.P. Loong et al.   FEBS LETTERS

Tropomyosin Dephosphorylation Results in Compensated Cardiac Hypertrophy

(2012) Emily M. Schulz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Testing for Dilated Cardiomyopathy in Clinical Practice

(2012) Neal K. Lakdawala et al.   JOURNAL OF CARDIAC FAILURE

Myofilament Protein Gene Mutation Screening and Outcome of Patients With Hypertrophic Cardiomyopathy

(2012) Iacopo Olivotto et al.   MAYO CLINIC PROCEEDINGS

DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges

(2012) Fan Bai et al.   PLoS One

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle

(2011) Yurii S. Borovikov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effect of the dilated cardiomyopathy-causing Glu40Lys TPM1 mutation on actin-myosin interactions during the ATPase cycle

(2011) Yurii S. Borovikov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin–myosin interaction during the ATPase cycle

(2011) Nikita A. Rysev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tropomyosin Position on F-Actin Revealed by EM Reconstruction and Computational Chemistry

(2011) Xiaochuan (Edward) Li et al.   BIOPHYSICAL JOURNAL

Enhanced Active Cross-Bridges during Diastole: Molecular Pathogenesis of Tropomyosin's HCM Mutations

(2011) Fan Bai et al.   BIOPHYSICAL JOURNAL

Prevalence and Distribution of Sarcomeric Gene Mutations in Japanese Patients With Familial Hypertrophic Cardiomyopathy

(2011) Haruna Otsuka et al.   CIRCULATION JOURNAL

Sarcomere Gene Mutations in Isolated Left Ventricular Noncompaction Cardiomyopathy Do Not Predict Clinical Phenotype

(2011) Susanne Probst et al.   Circulation-Cardiovascular Genetics

Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity?

(2011) E. Oechslin et al.   EUROPEAN HEART JOURNAL

Rapid detection of genetic variants in hypertrophic cardiomyopathy by custom DNA resequencing array in clinical practice

(2011) S. Fokstuen et al.   JOURNAL OF MEDICAL GENETICS

Inherited Cardiomyopathies

(2011) Hugh Watkins et al.   NEW ENGLAND JOURNAL OF MEDICINE

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

The Importance of Genetic Counseling, DNA Diagnostics, and Cardiologic Family Screening in Left Ventricular Noncompaction Cardiomyopathy

(2010) Yvonne M. Hoedemaekers et al.   Circulation-Cardiovascular Genetics

Coding Sequence Rare Variants Identified in MYBPC3 , MYH6 , TPM1 , TNNC1 , and TNNI3 From 312 Patients With Familial or Idiopathic Dilated Cardiomyopathy

(2010) Ray E. Hershberger et al.   Circulation-Cardiovascular Genetics

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

(2010) Polakit Teekakirikul et al.   JOURNAL OF CLINICAL INVESTIGATION

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation

(2010) Neal K. Lakdawala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death

(2010) Bo Chang et al.   MOLECULAR GENETICS AND METABOLISM

Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli

(2010) Matthew Johnson et al.   PLoS One

The effect of the dilated cardiomyopathy-causing mutation Glu54Lys of α-tropomyosin on actin–myosin interactions during the ATPase cycle

(2009) Yurii S. Borovikov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dilated cardiomyopathy mutations in α-tropomyosin inhibit its movement during the ATPase cycle

(2009) Yurii S. Borovikov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A child cohort study from southern Italy enlarges the genetic spectrum of hypertrophic cardiomyopathy

(2009) G Frisso et al.   CLINICAL GENETICS

Mutations in Sarcomere Protein Genes in Left Ventricular Noncompaction

(2008) Sabine Klaassen et al.   CIRCULATION

Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults

(2008) Hiroyuki Morita et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T

(2008) K. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA