Scutellarin inhibits the uninduced and metal-induced aggregation of α-Synuclein and disaggregates preformed fibrils: implications for Parkinson's disease

Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity

(2019) Hossein Mohammad-Beigi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Noradrenaline to native and intermediate states during fibrillation of α-Synuclein leads to the formation of stable and structured cytotoxic species

(2019) Priyanka Singh et al.   ACS Chemical Neuroscience

Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load

(2018) Nidhi Katyal et al.   ACS Chemical Neuroscience

Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice

(2018) Yue-Qin Zeng et al.   MOLECULES

Clinical benefits and pharmacology of scutellarin: A comprehensive review

(2018) Liping Wang et al.   PHARMACOLOGY & THERAPEUTICS

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T

(2018) Anna Sulatskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

(−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicity

(2017) Juan Zhao et al.   RSC Advances

Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

(2017) Jialiang Gao et al.   Frontiers in Pharmacology

A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP

(2016) Lu Xiao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

(2016) Youssra K. Al-Hilaly et al.   Scientific Reports

Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation

(2016) Hyuck Jin Lee et al.   Inorganic Chemistry Frontiers

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42)

(2015) David J. Lindberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

(2015) Dhiman Ghosh et al.   Scientific Reports

Enhancement of the oral bioavailability of breviscapine by nanoemulsions drug delivery system

(2014) Yan Ma et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Weak protein complexes: challenging to study but essential for life

(2014) Jun Qin et al.   FEBS Journal

Improved oral bioavailability of breviscapine via a Pluronic P85-modified liposomal delivery system

(2014) Yue Zhou et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia–reperfusion in rats

(2014) Hao Tang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

(2014) Alaina S. DeToma et al.   Chemical Science

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin

(2012) Li-Li Guo et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase

(2011) Li-li Guo et al.   ACTA PHARMACOLOGICA SINICA

Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

(2011) Alaina S. DeToma et al.   CHEMBIOCHEM

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein

(2008) Dong-Pyo Hong et al.   JOURNAL OF MOLECULAR BIOLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY