Article
Neurosciences
Teng He, Di Wang, Zifeng Wu, Chaoli Huang, Xiangyang Xu, Xiangqing Xu, Cunming Liu, Kenji Hashimoto, Chun Yang
Summary: This study provides a comprehensive bibliometric analysis of research on (R)-ketamine, showing its rapid-onset and sustained antidepressant effects and the growing interest in recent years.
Article
Chemistry, Organic
Henrik Weber, Nils Drouve, Lana Kortenbrede, Sherif El Sheikh
Summary: In this study, the synthesis of aryl derivatives of ketamine and its major metabolites was reported using a Diels-Alder reaction, resulting in a substituted cyclohexane core structure. The method demonstrated broad applicability.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Neurosciences
Huihui Miao, Kang Yu, Danyang Gao, Xiaowan Lin, Ying Cao, Xiao Liu, Hui Qiao, Tianzuo Li
Summary: This study conducted a comprehensive analysis of research on ketamine and highlighted the growing interest in ketamine and its antidepressant effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Hartej Gill, Barjot Gill, Nelson B. Rodrigues, Orly Lipsitz, Joshua Daniel Rosenblat, Sabine El-Halabi, Flora Nasri, Rodrigo B. Mansur, Yena Lee, Roger S. McIntyre
Summary: Research suggests that intravenous ketamine may have positive effects on cognition in TRD patients, including improvements in working memory and visual learning memory, although symptoms in anxious TRD participants may show more significant improvement.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Alvaro Lopez-Diaz, Luisa Rendon de Lope, Diego de la Vega Sanchez
Summary: More data on the long-term effects of Racemic Ketamine and Esketamine in TDR patients is needed, and the implementation of centralized registries for tracking their use in depression treatment could be crucial for assessing their efficacy and safety in real-world clinical practice. This paper outlines the emergence and rationale behind these registry-based surveillance systems.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Behavioral Sciences
Michael Colla, Hanne Scheerer, Steffi Weidt, Erich Seifritz, Golo Kronenberg
Summary: The serendipitous discovery of ketamine's antidepressant effects represents a major breakthrough in neuropsychopharmacological research, challenging traditional concepts of antidepressant drug therapy. Current theories of antidepressant drug action include monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Torsten Meyer, Martin Brunovsky, Jiri Horacek, Tomas Novak, Veronika Andrashko, Erich Seifritz, Sebastian Olbrich
Summary: The study demonstrates the predictive value of heart rate and heart rate variability power for ketamine treatment in major depressive disorder. These factors can also differentiate between responders and non-responders, highlighting the importance of the autonomous nervous system in MDD. Further research on the predictive power of HR and HRV markers is recommended for optimizing treatment options for MDD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Neurosciences
Ezio Carboni, Anna R. Carta, Elena Carboni, Antonello Novelli
Summary: Repurposing ketamine in the therapy of depression could lead to a breakthrough in understanding the etiology of depression. The use of ketamine as a fast-acting antidepressant in treatment-resistant patients has sparked interest in its mechanism of action and potential effects. Further research is needed to explore its clinical applications and long-term implications.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Margaret S. Butler, Sera L. Young, Emily L. Tuthill
Summary: The study found a negative correlation between perinatal depressive symptoms and the exclusivity and duration of breastfeeding, which may lead to suboptimal infant nutrition and harmful impacts on maternal mental and physical health.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Solveig Vieluf, Rima El Atrache, Sarah Cantley, Michele Jackson, Justice Clark, Theodore Sheehan, William J. Bosl, Bo Zhang, Tobias Loddenkemper
Summary: This study tested the differences in 24-hour modulation patterns between patients with and without seizures and explored the potential of using these differences to forecast seizure risk. The results suggest that monitoring and forecasting seizure risk can be achieved by analyzing wearable recordings in combination with clinical variables.
SCIENTIFIC REPORTS
(2022)
Review
Psychiatry
Vitor Breseghello Cavenaghi, Leandro Paulino da Costa, Acioly Luiz Tavares Lacerda, Edson Shiguemi Hirata, Euripedes Constantino Miguel, Renerio Fraguas
Summary: This systematic review examines the efficacy, safety, and tolerability of subcutaneous racemic ketamine and esketamine in depression. The results show that subcutaneous administration of racemic ketamine and esketamine demonstrates rapid and robust antidepressant effects, with response/remission rates ranging from 50 to 100%, but also with transient side effects. Further studies are needed to explore the cost-effectiveness of the subcutaneous route and compare it directly with intravenous and intranasal protocols.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Carmen Schiweck, Erika Lutin, Walter De Raedt, Olivia Cools, Violette Coppens, Manuel Morrens, Chris Van Hoof, Elske Vrieze, Stephan Claes
Summary: Abnormalities in heart rate and its variability persist in patients with major depressive disorder throughout a 24-hour day, with the highest fluctuation observed during the night. Baseline heart rate levels have the potential to predict treatment response, but do not serve as state markers for depression in this study.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Elizabeth M. Camacho, Gemma E. Shields, Emily Eisner, Elizabeth Littlewood, Kylie Watson, Carolyn A. Chew-Graham, Dean McMillan, Shehzad Ali, Simon Gilbody
Summary: This study aimed to evaluate the cost-effectiveness of case-finding for postnatal depression (PND) in women with risk factors. The study found that universal case-finding for PND is more cost-effective compared to targeted case-finding.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Linying Liu, Haijian Huang, Yongbin Li, Ruochen Zhang, Yongbao Wei, Weiwei Wu
Summary: Ketamine is an anaesthetic agent used to treat depression but increasingly abused for recreational purposes, leading to dissociative side effects and organ dysfunction. This study reports a case of severe brain atrophy related to Ketamine abuse and investigates the mechanism behind it, providing insights into the addictive nature and harmful effects of Ketamine abuse.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Justin P. Reinert, Brittany L. Parmentier
Summary: As the use of ketamine expands, clinicians need to be aware that its effects may overlap. Patients outside the perioperative setting may benefit from ketamine as an analgesic or sedative to alleviate mood and depression. Ketamine's impact on postoperative mood and depression when administered as an anesthetic in the perioperative setting seems unclear and further studies are necessary.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Psychiatry
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
TRANSLATIONAL PSYCHIATRY
(2020)
Review
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: The study found that AChEIs may have antidepressant properties in mice, but with a strong dose-dependency. There is conflicting evidence regarding the mood-related properties of these drugs, and further research is needed to determine their effects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: Research indicates that acetylcholinesterase inhibitors exhibit an antidepressant-like effect in mice, showing a U-shaped dose-response curve. Three different AChEIs show therapeutic effects at low doses without causing hyperactivity or anxiolytic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)