Article
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: Research indicates that acetylcholinesterase inhibitors exhibit an antidepressant-like effect in mice, showing a U-shaped dose-response curve. Three different AChEIs show therapeutic effects at low doses without causing hyperactivity or anxiolytic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, General & Internal
Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park
Summary: A study conducted in South Korea found that the use of alpha-GPC was associated with a higher 10-year stroke risk in a dose-response manner. Alpha-GPC users had a higher risk for both ischemic and hemorrhagic stroke compared to nonusers. Further research is needed to understand the mechanisms behind this potential cerebrovascular risk.
Article
Neurosciences
Disen Mei, Fangmin Wang, Bo Yuan, Miaojun Lai, Yiying Zhou, Wei Cui, Huifen Liu, Wenhua Zhou
Summary: The study found that donepezil can inhibit heroin intake and heroin-seeking behavior. It regulates dopamine receptors in the nucleus accumbens by increasing acetylcholine, suggesting that it may be a potential approach for the treatment of heroin misuse.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Haihua Qiu, Yibo Zhang, Zhongyu Li, Ping Jiang, Shuhong Guo, Yi He, Yuan Guo
Summary: The study found that donepezil effectively enhanced parasympathetic activity, reduced mean pulmonary arterial pressure and RV systolic pressure in MCT-treated rats, reversed pulmonary arterial remodeling and RV dysfunction, suppressed inflammatory response and promoted cell apoptosis. Importantly, donepezil reduced cell proliferation and promoted apoptosis by inhibiting M2-macrophage activation in PAH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Mahdieh Sadeghi, Zakaria Zakariaei, Mostafa Soleymani, Abdollah Malakian
Summary: This article describes a case of a 2-year-old infant who developed cholinergic syndrome after accidental ingestion of donepezil tablets and was discharged in stable condition.
CLINICAL CASE REPORTS
(2022)
Article
Neurosciences
Sami Alzarea, Hassan H. Alhassan, Abdulaziz Alzarea, Ziad H. Al-Oanzi, Muhammad Afzal
Summary: The study aims to determine the impact of renin inhibitor Aliskiren on lipopolysaccharide-induced depressive-like behavior and neuroinflammation in mice. The results demonstrate that Aliskiren can mitigate the negative effects of lipopolysaccharide on mouse behavior and brain inflammation.
Article
Neurosciences
Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping Xu
Summary: This study is the first to demonstrate the antidepressant-like effects of FMN in a CORT-induced mice model of depression, suggesting it as a potential candidate for treating depression.
Article
Psychiatry
William H. Roughan, Adrian Campos, Luis M. Garcia-Marin, Gabriel Cuellar-Partida, Michelle K. Lupton, Ian B. Hickie, Sarah E. Medland, Naomi R. Wray, Enda M. Byrne, Trung Thanh Ngo, Nicholas G. Martin, Miguel E. Renteria
Summary: The study found a bidirectional relationship between chronic pain and depression, with chronic pain increasing the risk of depression, recent suicide attempts, smoking, and painkiller misuse. Individuals with comorbid chronic pain and depression experienced poorer treatment response to antidepressants, especially sertraline, escitalopram, and venlafaxine. Participants taking these medications specifically for chronic pain reported lower benefits compared to those taking them for other indications.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Jun-ying Wang, Yue Zhang, Yu Chen, Yu Wang, Shao-yuan Li, Yi-fei Wang, Zi-xuan Zhang, Jinling Zhang, Peijing Rong
Summary: The anti-inflammatory signal of the vagus nerve mediated by alpha 7 nicotinic acetylcholine receptor (alpha 7nAchR) plays a critical role in the antidepressant effect of transcutaneous auricular vagus nerve stimulation (taVNS). The hippocampus region regulates emotions and has the most distribution of alpha 7nAchR, indicating its involvement in the taVNS antidepressant effect.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Lu Sun, Rikst-Nynke Verkaik-Schakel, Knut Biber, Torsten Ploesch, Tsvetan Serchov
Summary: The research demonstrated that stress-induced depression-like behavior and antidepressant treatments are associated with epigenetic alterations of the Homer1 promoter, providing new insights into the mechanism of antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Olga Pol
Summary: The study demonstrates the anxiolytic and antidepressant properties of DADS and GYY4137 during neuropathic pain, revealing their analgesic actions through inhibition of inflammatory, apoptotic, and oxidative responses. These findings support the use of these treatments for managing affective disorders accompanying chronic neuropathic pain.
Article
Psychiatry
Ning Jiang, Haixia Wang, Hong Huang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xinmin Liu
Summary: Medicinal plant species in Shen yuan prescription demonstrate potent antidepressant-like effects, reversing depressive-like behaviors in rats by regulating neurotransmitter levels, suppressing neuroinflammation, and activating BDNF/TrkB pathway, among other mechanisms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Chorpeth Chalermwongkul, Charinya Khamphukdee, Juthamart Maneenet, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit
Summary: Major depressive disorder (MDD) is a prevalent worldwide disease with unclear etiology. Herbal medicine is gaining interest as an alternative antidepressant, and Oroxylum indicum extract containing baicalin and baicalein shows potential as an effective treatment for MDD by normalizing the HPA axis function and improving neurogenesis.
Article
Multidisciplinary Sciences
Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Kazuhisa Aoki, Naomi Nihonmatsu-Kikuchi, Toshikazu Shinba, Yoshitaka Tatebayashi
Summary: Chronic antidepressant treatment can significantly alleviate social avoidance, sleep disturbances, and EEG abnormalities in rodent chronic stress models. Additionally, reduced REM sleep theta power may be a core sleep symptom in socially defeated rats.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Lanwei Hou, Jingyu Miao, Haiwei Meng, Xiao Liu, Di Wang, Yawen Tan, Chuangang Li
Summary: This study found that S-ketamine can alleviate depression-like behavior by upregulating SIRT1-mediated BDNF in the medial prefrontal cortex (mPFC).
FRONTIERS IN PSYCHIATRY
(2022)
Review
Behavioral Sciences
Andrew J. Polis, Paul J. Fitzgerald, Pho J. Hale, Brendon O. Watson
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Psychiatry
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Behavioral Sciences
Paul J. Fitzgerald, Pho J. Hale, Anjesh Ghimire, Brendon O. Watson
Summary: Research indicates that acetylcholinesterase inhibitors exhibit an antidepressant-like effect in mice, showing a U-shaped dose-response curve. Three different AChEIs show therapeutic effects at low doses without causing hyperactivity or anxiolytic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)