NFκB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type–Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve

Macrophage Transitions in Heart Valve Development and Myxomatous Valve DiseaseHighlights

(2018) Alexia Hulin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of IκB‐Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β‐Catenin–Runt‐Related Transcription Factor 2 Signaling

(2018) Isehaq Al‐Huseini et al.   Journal of the American Heart Association

Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study

(2016) Joanna L. d'Arcy et al.   EUROPEAN HEART JOURNAL

Sex-related differences in matrix remodeling and early osteogenic markers in aortic valvular interstitial cells

(2016) Shirin Masjedi et al.   HEART AND VESSELS

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Early aortic valve inflammation precedes calcification: A longitudinal FDG-PET/CT study

(2015) Amr Abdelbaky et al.   ATHEROSCLEROSIS

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Correction: Endothelial-Derived Oxidative Stress Drives Myofibroblastic Activation and Calcification of the Aortic Valve

(2015) Emily J. Farrar et al.   PLoS One

Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase

(2014) Ramzi N. El Accaoui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

(2014) M. Cuchel et al.   EUROPEAN HEART JOURNAL

Expression of smooth muscle cell markers and co-activators in calcified aortic valves

(2014) Najma Latif et al.   EUROPEAN HEART JOURNAL

Side-Specific Endothelial-Dependent Regulation of Aortic Valve Calcification

(2013) Jennifer Richards et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterogeneous Susceptibility of Valve Endothelial Cells to Mesenchymal Transformation in Response to TNFα

(2013) Emily J. Farrar et al.   ANNALS OF BIOMEDICAL ENGINEERING

Molecular and Cellular Aspects of Calcific Aortic Valve Disease

(2013) Dwight A. Towler   CIRCULATION RESEARCH

Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions

(2013) Seiichiro Ishihara et al.   EXPERIMENTAL CELL RESEARCH

Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

(2013) Robert M. Weiss et al.   PLoS One

Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells

(2012) Gretchen J. Mahler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops

(2012) Chen Li et al.   CARDIOVASCULAR PATHOLOGY

Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling

(2012) Bingruo Wu et al.   CELL

Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease

(2012) Nancy Coté et al.   INFLAMMATION

The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription

(2012) Jelena Stanisavljevic et al.   JOURNAL OF CELL SCIENCE

NEMO Ensures Signaling Specificity of the Pleiotropic IKKβ by Directing Its Kinase Activity toward IκBα

(2012) Bärbel Schröfelbauer et al.   MOLECULAR CELL

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells

(2011) Casey J. Holliday et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL

(2011) Meritxell Nus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation

(2011) Bingruo Wu et al.   CIRCULATION RESEARCH

Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve Calcification

(2011) Sophie E.P. New et al.   CIRCULATION RESEARCH

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve

(2011) K. Balachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

(2010) Kikuo Isoda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of nuclear factor κB in cardiovascular health and disease

(2010) Kim van der Heiden et al.   CLINICAL SCIENCE

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation

(2010) Jesper Hjortnaes et al.   EUROPEAN HEART JOURNAL

BAY 11-7082, a Nuclear Factor-κB Inhibitor, Reduces Inflammation and Apoptosis in a Rat Cardiac Ischemia-Reperfusion Injury Model

(2010) Yong Sook Kim et al.   International Heart Journal

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential

(2009) Jan-Hung Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

(2009) Katrin Hess et al.   BONE

Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice

(2009) Jordan D. Miller et al.   CIRCULATION

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

(2009) Xiaoping Yang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps

(2009) Ismail El-Hamamsy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Stage-Related Effect of Statin Treatment on the Progression of Aortic Valve Sclerosis and Stenosis

(2008) Francesco Antonini-Canterin et al.   AMERICAN JOURNAL OF CARDIOLOGY

Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis

(2008) Anne B. Rossebø et al.   NEW ENGLAND JOURNAL OF MEDICINE

Calcific Aortic Stenosis — Time to Look More Closely at the Valve

(2008) Catherine M. Otto   NEW ENGLAND JOURNAL OF MEDICINE