Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

Regional structure–function relationships in mouse aortic valve tissue

(2010) Varun K. Krishnamurthy et al.   JOURNAL OF BIOMECHANICS

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors

(2010) Franziska Meier-Stiegen et al.   PLoS One

Mechanical Strain and the Aortic Valve: Influence on Fibroblasts, Extracellular Matrix, and Potential Stenosis

(2009) Sven Lehmann et al.   ANNALS OF THORACIC SURGERY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Calcific aortic valve disease: outflow obstruction is the end stage of a systemic disease process

(2009) C. M. Otto   EUROPEAN HEART JOURNAL

Notch1 represses osteogenic pathways in aortic valve cells

(2009) Vishal Nigam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2

(2009) Xiaoping Yang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis

(2008) T. Quillard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

(2008) K. L. McBride et al.   HUMAN MOLECULAR GENETICS

Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves

(2008) Alexandros Alexopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Control of the adaptive response of the heart to stress via the Notch1 receptor pathway

(2008) Adrien Croquelois et al.   JOURNAL OF EXPERIMENTAL MEDICINE