Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate‐induced long‐term neurotoxicity in the rat model

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

(2019) Asheebo Rojas et al.   NEUROBIOLOGY OF DISEASE

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication

(2019) Michelle Guignet et al.   NEUROBIOLOGY OF DISEASE

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model

(2019) Marson Putra et al.   NEUROBIOLOGY OF DISEASE

Hazardous Chemical Emergencies and Poisonings

(2019) Fred M. Henretig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication

(2019) Donald A. Bruun et al.   NEUROTOXICOLOGY

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy

(2019) Tawfeeq Shekh-Ahmad et al.   Redox Biology

Novichok: a murderous nerve agent attack in the UK

(2018) J. Allister Vale et al.   CLINICAL TOXICOLOGY

Oxidative stress in organophosphate poisoning: role of standard antidotal therapy

(2018) Nela Vanova et al.   JOURNAL OF APPLIED TOXICOLOGY

Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

(2018) Shaunik Sharma et al.   NEUROBIOLOGY OF DISEASE

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

(2018) Xiaofeng Zhao et al.   Cell Reports

Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models

(2018) Shaunik Sharma et al.   Frontiers in Neurology

Inhibition of NADPH Oxidase Activation by Apocynin Rescues Seizure-Induced Reduction of Adult Hippocampal Neurogenesis

(2018) Song Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model

(2018) Li-Ping Liang et al.   Redox Biology

Syria chemical attacks: preparing for the unconscionable

(2017) John Zarocostas   LANCET

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

From the Cover: Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate

(2017) Brad A. Hobson et al.   TOXICOLOGICAL SCIENCES

Editor’s Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate

(2017) Sílvia Sisó et al.   TOXICOLOGICAL SCIENCES

Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides

(2016) Hilary S. McCarren et al.   Annals of the New York Academy of Sciences

The role of oxidative stress in organophosphate and nerve agent toxicity

(2016) Jennifer N. Pearson et al.   Annals of the New York Academy of Sciences

Long-term neuropathological and behavioral impairments after exposure to nerve agents

(2016) Vassiliki Aroniadou-Anderjaska et al.   Annals of the New York Academy of Sciences

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

(2016) Brenna M. Flannery et al.   Journal of Neuroinflammation

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

(2016) Sreekanth Puttachary et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

(2016) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration

(2016) Aram B. Cholanians et al.   TOXICOLOGICAL SCIENCES

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

(2015) Sreekanth Puttachary et al.   Biomed Research International

Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle

(2014) Hesham M. Ismail et al.   PLoS One

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP

(2014) Sameh El Sayed et al.   ChemistryOpen

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death

(2013) Jin Hee Kim et al.   BRAIN RESEARCH

Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions

(2013) Doodipala Reddy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury

(2013) Sean J Cooney et al.   Journal of Neuroinflammation

Syrian gas attack reinforces need for better anti-sarin drugs

(2013) Elie Dolgin   NATURE MEDICINE

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse

(2013) Brian P. Dranka et al.   NEUROSCIENCE LETTERS

Characterization of status epilepticus induced by two organophosphates in rats

(2012) Marko S. Todorovic et al.   EPILEPSY RESEARCH

N w-Propyl-l-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses

(2012) Edward Beamer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

(2012) Anamitra Ghosh et al.   Journal of Neuroinflammation

Chemical toxins that cause seizures

(2012) David A. Jett   NEUROTOXICOLOGY

Organophosphate-induced brain damage: Mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies

(2012) Yun Chen   NEUROTOXICOLOGY

Capsule Influences the Deposition of Critical Complement C3 Levels Required for the Killing of Burkholderia pseudomallei via NADPH-Oxidase Induction by Human Neutrophils

(2012) Michael E. Woodman et al.   PLoS One

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

(2011) W. Liu et al.   LIFE SCIENCES

NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion

(2011) Kazutoshi Murotomi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage

(2011) Bashkim Kadriu et al.   NEUROPHARMACOLOGY

Nerve agent intoxication: Recent neuropathophysiological findings and subsequent impact on medical management prospects

(2011) Jean-Marc Collombet   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells

(2010) Marília P.P. Kanegae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague-Dawley rats

(2010) Marcio De Araujo Furtado et al.   EPILEPSIA

Development of a Prolonged Calcium Plateau in Hippocampal Neurons in Rats Surviving Status Epilepticus Induced by the Organophosphate Diisopropylfluorophosphate

(2010) Laxmikant S. Deshpande et al.   TOXICOLOGICAL SCIENCES

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Synthesis of Diapocynin

(2009) Ron Luchtefeld et al.   JOURNAL OF CHEMICAL EDUCATION

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: Comparative effects of atropine and cannabinomimetics

(2009) Linnzi K.M. Wright et al.   NEUROTOXICOLOGY AND TERATOLOGY

Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist

(2009) Snjezana Zaja-Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice

(2008) F. Pibiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose Formulation and Analysis of Diapocynin

(2007) Ron Luchtefeld et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin

(2007) Qun Wang et al.   PHYTOMEDICINE