Synthesis and structure−activity relationships of teixobactin

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

(2019) Yu Zong et al.   Nature Communications

Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II

(2019) Sorina Chiorean et al.   CHEMBIOCHEM

The impact of backbone N ‐methylation on the structure‐activity relationship of Leu 10 ‐teixobactin

(2019) Tony Velkov et al.   JOURNAL OF PEPTIDE SCIENCE

Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study

(2018) Shimaa A.H. Abdel Monaim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine

(2018) Kang Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

(2018) Georgina C. Girt et al.   CHEMICAL COMMUNICATIONS

Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus , Propionibacterium acnes and Pseudomonas aeruginosa

(2018) Vivian Ng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin

(2018) Yu Zong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

(2018) Anish Parmar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity

(2018) Dhanaraju Mandalapu et al.   JOURNAL OF ORGANIC CHEMISTRY

Probing Key Elements of Teixobactin-Lipid II Interactions in Membrane

(2018) Po-Chao Wen et al.   Chemical Science

In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates

(2018) Estelle J. Ramchuran et al.   Frontiers in Microbiology

Structural studies suggest aggregation as one of the modes of action for teixobactin

(2018) Carl Öster et al.   Chemical Science

Teixobactin: a novel anti-infective agent

(2018) Matthew W. McCarthy   Expert Review of Anti-Infective Therapy

X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly

(2018) Hyunjun Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)

(2018) Ruba Malkawi et al.   Pharmaceutics

Antimicrobial resistance in healthcare, agriculture and the environment: the biochemistry behind the headlines

(2017) Henrietta Venter et al.   Essays in Biochemistry

Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP)

(2017) Shimaa A. H. Abdel Monaim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of the N-Terminus Amino Function of Arg10-Teixobactin

(2017) Shimaa A. H. Abdel Monaim et al.   MOLECULES

Synthesis and biological evaluation of novel teixobactin analogues

(2017) Christian E. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

(2017) Anish Parmar et al.   Chemical Science

Synthesis and structure–activity relationship studies of teixobactin analogues

(2017) Chunlei Wu et al.   RSC Advances

Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery

(2017) William D. Fiers et al.   ACS Infectious Diseases

Binding Modes of Teixobactin to Lipid II: Molecular Dynamics Study

(2017) Yang Liu et al.   Scientific Reports

Elucidation of the Teixobactin Pharmacophore

(2016) Hyunjun Yang et al.   ACS Chemical Biology

Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis

(2016) Tomoyuki Homma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

(2016) Darcy J Atkinson et al.   Beilstein Journal of Organic Chemistry

Efficient total syntheses and biological activities of two teixobactin analogues

(2016) Anish Parmar et al.   CHEMICAL COMMUNICATIONS

New Found Hope for Antibiotic Discovery: Lipid II Inhibitors

(2016) Vivian Ng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Solution-Phase Synthesis of the Macrocyclic Core of Teixobactin

(2016) Santu Dhara et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

China bans colistin as a feed additive for animals

(2016) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Total Synthesis of Teixobactin

(2016) Andrew M. Giltrap et al.   ORGANIC LETTERS

Total synthesis of teixobactin

(2016) Kang Jin et al.   Nature Communications

Multiple Attack on Bacteria by the New Antibiotic Teixobactin

(2015) Franz von Nussbaum et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

A Highly Stereoselective and Scalable Synthesis of l-allo-Enduracididine

(2015) William Craig et al.   ORGANIC LETTERS

Synthesis and Biological Evaluation of a Teixobactin Analogue

(2015) Yahya E. Jad et al.   ORGANIC LETTERS

Propionibacterium acnes: from Commensal to Opportunistic Biofilm-Associated Implant Pathogen

(2014) Y. Achermann et al.   CLINICAL MICROBIOLOGY REVIEWS

Wall Teichoic Acids of Gram-Positive Bacteria

(2013) Stephanie Brown et al.   Annual Review of Microbiology

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics

(2013) Edward WC Sewell et al.   JOURNAL OF ANTIBIOTICS

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Protein chemical synthesis by serine and threonine ligation

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cultivation of unculturable soil bacteria

(2012) Van H.T. Pham et al.   TRENDS IN BIOTECHNOLOGY

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Community-associated meticillin-resistant Staphylococcus aureus

(2010) Frank R DeLeo et al.   LANCET

A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface

(2009) J. B. Hamburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid II: A central component in bacterial cell wall synthesis and a target for antibiotics

(2008) Ben de Kruijff et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS