An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells

Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site

(2019) Shu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caged luciferins for bioluminescent activity-based sensing

(2019) Timothy A Su et al.   CURRENT OPINION IN BIOTECHNOLOGY

Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging

(2018) Wen Chyan et al.   ACS Chemical Biology

Activity-based sensing fluorescent probes for iron in biological systems

(2018) Allegra T Aron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In Vivo Brain Imaging, Biodistribution, and Radiation Dosimetry Estimation of [11C]Celecoxib, a COX-2 PET Ligand, in Nonhuman Primates

(2018) J. Kumar et al.   MOLECULES

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

(2018) Chelsea Anorma et al.   ACS Central Science

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

(2018) Jing Ning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

(2017) Gino Cingolani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice

(2017) H Chen et al.   ONCOGENE

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer

(2017) Debashree Basudhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory ω-3 endocannabinoid epoxides

(2017) Daniel R. McDougle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies

(2016) Dawid Dębski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit

(2016) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of rofecoxib bound to human cyclooxygenase-2

(2016) Benjamin J. Orlando et al.   Acta Crystallographica Section F-Structural Biology Communications

A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

(2015) Lin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis

(2015) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A

(2015) Zi-Ru Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

(2015) Nicholas S. Kirkby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models

(2014) Lin Li et al.   Nature Communications

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents

(2013) Md. Jashim Uddin et al.   BIOCONJUGATE CHEMISTRY

Fluorescence Discrimination of Cancer from Inflammation by Molecular Response to COX-2 Enzymes

(2013) Hua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Off–On COX-2-Specific Fluorescent Probe: Targeting the Golgi Apparatus of Cancer Cells

(2013) Hua Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α

(2012) Dimitrios Tsikas et al.   FEBS LETTERS

Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2Production in Astrocytes

(2012) Miriam Font-Nieves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Unique Approach to Development of Near-Infrared Fluorescent Sensors for in Vivo Imaging

(2012) Lin Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of Enzymatically Generated Hydrogen Peroxide by Metal-Based Fluorescent Probe

(2011) Yutaka Hitomi et al.   ANALYTICAL CHEMISTRY

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study

(2011) Bruno St-Jacques et al.   JOURNAL OF NEUROCHEMISTRY

Gastroprotective Effect of Rutin against Indomethacin-Induced Ulcers in Rats

(2010) Ihab T. Abdel-Raheem   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents

(2010) Md. Jashim Uddin et al.   CANCER RESEARCH

Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2

(2010) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers

(2009) Chong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Aspects of Horseradish Peroxidase Elucidated through Single-Molecule Studies

(2009) Hans H. Gorris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin

(2008) O. Pastoris et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Evaluation of [11C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation

(2007) Erik F.J. de Vries et al.   NUCLEAR MEDICINE AND BIOLOGY