3-O -Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake

Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions

(2019) Xing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Microglia in the Spread of Tau: Relevance for Tauopathies

(2018) Juan R. Perea et al.   Frontiers in Cellular Neuroscience

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

A mutant-cell library for systematic analysis of heparan sulfate structure–function relationships

(2018) Hong Qiu et al.   NATURE METHODS

Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci

(2018) Aree Witoelar et al.   Scientific Reports

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

(2018) Alessia Lasorsa et al.   Frontiers in Molecular Neuroscience

Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate

(2017) Zhangjie Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

(2017) Emily J. Koller et al.   Molecular Neurodegeneration

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Expanding the 3-O-Sulfate Proteome—Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity

(2016) Bryan E. Thacker et al.   ACS Chemical Biology

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer’s disease-related tau pathology

(2015) Julia Elisa Sepulveda-Diaz et al.   BRAIN

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

(2015) R. S. Desikan et al.   CIRCULATION

Distinct Therapeutic Mechanisms of Tau Antibodies

(2015) Kristen E. Funk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate 3-O-sulfation: A rare modification in search of a function

(2013) Bryan E. Thacker et al.   MATRIX BIOLOGY

Herpes virus in Alzheimer's disease: relation to progression of the disease

(2013) Ilaria Carbone et al.   NEUROBIOLOGY OF AGING

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein

(2011) Nathalie Sibille et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The proline-rich domain of tau plays a role in interactions with actin

(2009) Hai He et al.   BMC CELL BIOLOGY

Characteristics and consequences of muscarinic receptor activation by tau protein

(2009) Alberto Gómez-Ramos et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Tetrasulfated Disaccharide Unit in Heparan Sulfate

(2008) Hideo Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY