Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism

Inflammation and its role in age-related macular degeneration

(2016) Anu Kauppinen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration

(2016) Deborah A. Ferrington et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Regulation of age-related macular degeneration-like pathology by complement factor H

(2015) Christopher B. Toomey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection and replication of epistasis influencing transcription in humans

(2014) Gibran Hemani et al.   NATURE

Another explanation for apparent epistasis

(2014) Andrew R. Wood et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AprioriGWAS, a New Pattern Mining Strategy for Detecting Genetic Variants Associated with Disease through Interaction Effects

(2014) Qingrun Zhang et al.   PLoS Computational Biology

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

SNP Set Association Analysis for Genome-Wide Association Studies

(2013) Min Cai et al.   PLoS One

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Interpreting noncoding genetic variation in complex traits and human disease

(2012) Lucas D Ward et al.   NATURE BIOTECHNOLOGY

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Inverse Ising Inference Using All the Data

(2012) Erik Aurell et al.   PHYSICAL REVIEW LETTERS

Improved Statistics for Genome-Wide Interaction Analysis

(2012) Masao Ueki et al.   PLoS Genetics

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Gene- or region-based association study via kernel principal component analysis

(2011) Qingsong Gao et al.   BMC GENETICS

Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases

(2011) R. Fan et al.   GENETIC EPIDEMIOLOGY

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

(2011) David Weismann et al.   NATURE

Basic statistical analysis in genetic case-control studies

(2011) Geraldine M Clarke et al.   Nature Protocols

Ranking causal variants and associated regions in genome-wide association studies by the support vector machine and random forest

(2011) Usman Roshan et al.   NUCLEIC ACIDS RESEARCH

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

(2011) F. Morcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying Causal Genes and Dysregulated Pathways in Complex Diseases

(2011) Yoo-Ah Kim et al.   PLoS Computational Biology

Testing for an Unusual Distribution of Rare Variants

(2011) Benjamin M. Neale et al.   PLoS Genetics

A variable selection method for genome-wide association studies

(2010) Qianchuan He et al.   BIOINFORMATICS

Discriminant analysis of principal components: a new method for the analysis of genetically structured populations

(2010) Thibaut Jombart et al.   BMC GENETICS

SNP Selection in genome-wide and candidate gene studies via penalized logistic regression

(2010) Kristin L. Ayers et al.   GENETIC EPIDEMIOLOGY

Analysing biological pathways in genome-wide association studies

(2010) Kai Wang et al.   NATURE REVIEWS GENETICS

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

(2010) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Statistic for Genome-Wide Interaction Analysis

(2010) Xuesen Wu et al.   PLoS Genetics

Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

(2009) Anand Swaroop et al.   Annual Review of Genomics and Human Genetics

INTERSNP: genome-wide interaction analysis guided by a priori information

(2009) C. Herold et al.   BIOINFORMATICS

Genome-wide association analysis by lasso penalized logistic regression

(2009) Tong Tong Wu et al.   BIOINFORMATICS

Multilocus analysis of age-related macular degeneration

(2009) Julie Bergeron-Sawitzke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

An evaluation of statistical approaches to rare variant analysis in genetic association studies

(2009) Andrew P. Morris et al.   GENETIC EPIDEMIOLOGY

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

(2008) B. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY