A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease

Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease

(2015) Takuya Kitamoto et al.   JOURNAL OF HEPATOLOGY

Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease

(2015) Müjdat Zeybel et al.   Clinical Epigenetics

Epigenetics: Relevance and Implications for Public Health

(2014) Laura S. Rozek et al.   Annual Review of Public Health

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acid receptors in non-alcoholic fatty liver disease

(2013) Yuanyuan Li et al.   BIOCHEMICAL PHARMACOLOGY

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver

(2013) Jeff L. Staudinger et al.   DRUG METABOLISM REVIEWS

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease

(2013) Cynthia A. Moylan et al.   HEPATOLOGY

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

(2013) April D. Lake et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

(2013) Magda E Price et al.   Epigenetics & Chromatin

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

(2012) Naoki Tanaka et al.   HEPATOLOGY

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

(2010) Pan Du et al.   BMC BIOINFORMATICS

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Down-regulation of SREBP-1c is associated with the development of burned-out NASH

(2010) Tadanobu Nagaya et al.   JOURNAL OF HEPATOLOGY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

(2008) B. Kong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Role of FXR in Disorders of Bile Acid Homeostasis

(2008) Jyrki J. Eloranta et al.   PHYSIOLOGY