Journal
TETRAHEDRON LETTERS
Volume 55, Issue 51, Pages 6959-6964Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.10.138
Keywords
Metal-free; Asymmetric hydrogenation; Asymmetric hydrosilylation; Frustrated Lewis pairs
Categories
Funding
- National Science Foundation of China [20802079, 21072194]
- National Basic Research Program of China [2010CB833300]
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The activation of H-2 for the catalytic hydrogenation of unsaturated compounds is one of the most useful reactions in both academia and chemical Industry, which has long been predominated by the transition-metal catalysis. However, metal-free hydrogen activation represents a formidable challenge, and has been less developed. The recent emerging chemistry of frustrated Lewis pairs (FLPs) with a combination of sterically encumbered Lewis acids and Lewis bases provides a promising approach for metal-free hydrogenation due to their amazing abilities for the challenging H-2 activation. In the past several years, the hydrogenation of a wide range of unsaturated compounds using FLP catalysts has been successfully developed. Despite these advances, the corresponding asymmetric hydrogenation is just in its start-up step. Similar to the mode of H H bond activation, Si H bond can also be activated by FLPs for the hydrosilylation of ketones and imines. But its asymmetric version is also not well-solved. This Letter will outline the recent important progress of metal-free catalytic asymmetric hydrogenation and hydrosilylation using FLP catalysts. (C) 2014 The Authors. Published by Elsevier Ltd.
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