Article
Biotechnology & Applied Microbiology
Yalan Deng, Yanbin Wen, Jun Yin, Jiabing Huang, Rongsen Zhang, Gui Zhang, Dongxu Qiu
Summary: This study reveals the role of corroded iron stents in endothelialization. Corroded iron stents promote endothelialization by increasing fibrin deposition on rough surfaces, thereby preventing clinical complications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Yuan Tian, Wen J. Seeto, Mayra A. Paez-Arias, Mariah S. Hahn, Elizabeth A. Lipke
Summary: The aim of this study was to investigate the ability of peptides and peptide combinations to support circulating endothelial colony forming cell (ECFC) rolling and adhesion under shear flow, informing bio-material design in moving toward rapid cardiovascular device endothelialization. The study finds that the performance of REDV-containing peptides in facilitating ECFC dynamic adhesion and capture can be improved by combination with alpha 5fi1 integrin-binding peptides, which support ECFC static adhesion. Moreover, when similar in length, the peptide combinations may have synergistic effects in capturing ECFCs.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Isra Marei, Blerina Ahmetaj-Shala, Chris R. Triggle
Summary: Stent thrombosis is a common complication in patients with type 2 diabetes undergoing percutaneous coronary intervention, and it is caused by delayed and impaired endothelialization of the stent. Using specific molecules to induce endothelial cell adhesion, proliferation, and function can improve stent endothelialization and prevent thrombosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Duy T. Nguyen, Alexander F. Smith, Juan M. Jimenez
Summary: Stent thrombosis is a high-risk event after stent implantation, with endothelial coverage being a critical factor. The study highlights the significant impact of stent strut height and geometry on reendothelialization, with streamlining and decreased strut height improving endothelial coverage.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Materials Science, Multidisciplinary
Dongxu Qiu, Jun Yin, Yanbin Wen, Jiabing Huang, Ting Lei, Changqing Chen, Jian Xia
Summary: This study investigated the effects of diabetes on the degradation of bioresorbable iron stents. The results showed that under hyperglycemic conditions, the degradation of iron stents increased, negatively affecting mechanical support properties and the biocompatibility of endothelial cells. It also promoted inflammatory responses. This is the first study to reveal the biological profile of iron stent degradation under hyperglycemic conditions.
MATERIALS & DESIGN
(2023)
Article
Cell Biology
Ioannis Isaioglou, Mansour M. Aldehaiman, Yanyan Li, Abdellatif Ait Lahcen, Sakandar Rauf, Asma S. Al-Amoodi, Umme Habiba, Abdullah Alghamdi, Shuho Nozue, Satoshi Habuchi, Khaled N. Salama, Jasmeen S. Merzaban
Summary: Exosomes released by cells communicate through integrins and E-selectin, as they navigate from the cell of origin to their destination. Surface modifications and signaling proteins within exosomes potentially alter the physiology of recipient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lin-Zhen Xia, Jun Tao, Yan-Jun Chen, Ling-Li Liang, Gui-fang Luo, Ze-Min Cai, Zuo Wang
Summary: The vascular endothelium plays a crucial role in maintaining normal blood vessel function, with endothelial damage leading to vascular lesions. Endothelial repair process (re-endothelialization) is important in inhibiting neointimal hyperplasia, but is inevitably influenced by promoting and inhibiting factors.
DNA AND CELL BIOLOGY
(2021)
Article
Oncology
Ofri Doppelt-Flikshtain, Amin Younis, Tal Tamari, Ofir Ginesin, Talia Shentzer-Kutiel, David Nikomarov, Gil Bar-Sela, Benjamin R. Coyac, Yehuda G. Assaraf, Hadar Zigdon-Giladi
Summary: Despite progress in the treatment of various cancers, the prognosis for patients with metastatic osteosarcoma remains poor. This study demonstrated that endothelial progenitor cells (EPCs) play a role in promoting osteosarcoma progression and aggressiveness through non-physical interactions, and revealed a potential underlying molecular mechanism. These findings suggest the possibility of developing EPCs-targeted therapies to inhibit osteosarcoma metastasis and improve treatment efficacy.
Article
Cell Biology
Xiaoli Wang, Fei Fang, Yinghao Ni, Hongchi Yu, Jia Ma, Li Deng, Chunli Li, Yang Shen, Xiaoheng Liu
Summary: In this study, it was found that VEC migration and adhesion together contributed to a percentage of endothelial recovery in different models, with migration being more dominant in flat and groove models. As the injury scales increased, the contribution of circulating VEC adhesion to endothelial repair also increased. This suggests the importance of both migration and adhesion in re-endothelialization, providing insights for surface modification of cardiovascular implants.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yalin Liu, Haoyong Yuan, Yuhong Liu, Chunyang Chen, Zhenjie Tang, Can Huang, Zuodong Ning, Ting Lu, Zhongshi Wu
Summary: A multifunctional nanoparticle-VEGF system consisting of chitosan, REDV peptide, heparin, and VEGF was developed to enhance anti-thrombosis and promote rapid endothelialization of small-diameter tissue-engineered vascular grafts. The results showed improved patency rates and endothelialization in a rabbit model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Mehdi Hassanpour, Amankeldi A. Salybekov, Shuzo Kobayashi, Takayuki Asahara
Summary: CD34 is a cell surface antigen expressed in stem/progenitor cells such as HSCs and EPCs, which are potential sources for regenerative therapy. CD34(+) cells have been shown to improve therapeutic angiogenesis through direct incorporation and paracrine activity. Preclinical, pilot, and clinical trials have demonstrated the safety and efficacy of CD34(+) cell therapy in various diseases. However, the clinical application of CD34(+) cell therapy has sparked debates and controversies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chungwon Park, Kwang-Sook Park, Mi Jin Jeong, Han Byul Kim, Inho Bae, Kyung Seob Lim, Mei-Xian Li, Young Joon Hong, Dong Keun Han, Yoon Ki Joung
Summary: A universal method of using cell-made extracellular matrices (ECMs) to coat substrates for therapeutic cell delivery is recommended to improve integration of implantable materials with surrounding tissues. ECM-coated substrates show promising results in supporting endothelial regeneration and inhibiting neointimal growth in in vivo experiments, making them more effective than traditional stents.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Ran Sun, Xuedong Wang, Yu Nie, Ao Hu, Hanrui Liu, Kun Zhang, Lu Zhang, Qihong Wu, Kuan Li, Chuchu Liu, Huan Zhang, Bingwen Zheng, Hong Li, Huayan Xu, Rong Xu, Hang Fu, Li Dai, Rongrong Jin, Yingkun Guo
Summary: This study develops a therapeutic protocol that improves the efficiency of endogenous endothelial progenitor cell (EPC)-based myocardial ischemic injury repair. The protocol is based on the use of neutrophils (NEs) to target lesions and release preloaded EPC-binding molecules. SPIO-enhanced magnetic resonance imaging (MRI) is used to monitor the therapeutic efficacy. The study demonstrates successful EPC capture, heart revascularization, and functional recovery in mice.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Ivan S. Alferiev, Bahman Hooshdaran, Benjamin B. Pressly, Philip W. Zoltick, Stanley J. Stachelek, Michael Chorny, Robert J. Levy, Ilia Fishbein
Summary: Impaired endothelialization is a major cause of in-stent restenosis and late stent thrombosis. This study proposes a novel strategy of stent endothelialization by seeding biotin-modified endothelial cells onto avidin-functionalized stents. Results showed that this strategy significantly reduced in-stent restenosis in a rat model.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Zi Wang, Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta
Summary: This study investigates the effect of gap between two stents on the distribution of endothelial cells (ECs). The results suggest that the presence of a gap affects EC migration and the endothelialization effect on the surface of the stents. Additionally, tilting the stents also leads to changes in EC density.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jialong Chen, Quanli Li, Jun Li, Manfred F. Maitz
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2016)
Article
Multidisciplinary Sciences
Weibo Zhang, Shuang Wang, Shaohua Ge, Jialong Chen, Ping Ji
ROYAL SOCIETY OPEN SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Shuang Wang, Yuanmeng Yang, Wei Li, Zichen Wu, Jiaojiao Li, Kehui Xu, Weibo Zhang, Xianyu Zheng, Jialong Chen
Article
Chemistry, Multidisciplinary
Chuchu Guo, Wendi Cui, Xiaowei Wang, Xiaoxuan Lu, Lulu Zhang, Xiangyang Li, Wei Li, Weibo Zhang, Jialong Chen
Article
Materials Science, Multidisciplinary
Xiaowei Wang, Kehui Xu, Wendi Cui, Xi Yang, Manfred F. Maitz, Wei Li, Xiangyang Li, Jialong Chen
Summary: This study demonstrated that an alkaline environment is favorable for the formation of silver nanoparticles (AgNPs) and results in more particles. Although AgNPs bearing titanium had lower biocompatibilities, significant improvements were observed after 7 days of mineralization in simulated body fluid. The pH 10/0.1 group exhibited remarkable osteogenesis, possibly due to their strong antibacterial properties and ability to promote mineralization.
MATERIALS & DESIGN
(2021)
Review
Biotechnology & Applied Microbiology
Xiaoxuan Lu, Zichen Wu, Kehui Xu, Xiaowei Wang, Shuang Wang, Hua Qiu, Xiangyang Li, Jialong Chen
Summary: Titanium and its alloys are widely used in orthopedic and dental implants due to their stable chemical properties and good biocompatibility. However, issues such as aseptic loosening and peri-implant infection still exist. Recent advancements in surface modification have provided strategies to enhance the bio-function and anti-infection properties of titanium implants, aiming to improve the interaction between these devices and the local biological environment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Runhuai Yang, Anqi Miao, Qianqian Tang, Yangyang Zhang, Miao Jin, Chen Gao, Jialong Chen, Fuzhou Niu, Tingting Luo, Guangli Liu
Summary: In this study, a micro device for soft continuum robots with variable elastic modulus, submillimeter size and suitability for movement and manipulation in narrow and fragile environment is proposed. The device utilizes infrared-thermo effect and shape memory alloys to achieve variable elastic modulus and switching between passive compliant moving mode and operation mode. The integration of smart biomedical materials in this device allows for wireless infrared-regulated, submillimeter-scale and variable-modulus structures for biomedical soft robots.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Biotechnology & Applied Microbiology
Zhangao Wei, Kexin Li, Shuang Wang, Lan Wen, Linghan Xu, Yankai Wang, Zirui Chen, Wei Li, Hua Qiu, Xiangyang Li, Jialong Chen
Summary: In this study, a simple method to prepare tunable polydopamine (pDA) coating shell on silver nanoparticles (AgNPs) was proposed. The reaction pH and temperature were tuned to obtain core-shell structures with different aggregation states and shell thickness. The coated AgNPs showed high antibacterial property and excellent biocompatibility. Both in vitro and in vivo tests demonstrated sustained antibacterial properties and preferable cell compatibility of the coated AgNPs, which also promoted osteogenesis and inhibited inflammation in an infected animal model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chen Gao, Yulin Lai, Liang Cheng, Yifan Cheng, Anqi Miao, Jialong Chen, Runhuai Yang, Fei Xiong
Summary: This study aims to determine the differential causes of stem cell proliferation and differentiation on aligned-random fibers with different elastic modulus, and to change the differential levels through a regulatory mechanism mediated by B-cell lymphoma 6 protein (BCL-6) and miRNA-126-5p (miR-126-5p). The results showed that aligned fibers have phosphatidylinositol(4,5)bisphosphate alterations, excellent cytocompatibility, regular cytoskeleton, and high differentiation potential. The level of proliferative differentiation genes in cells is altered by BCL-6 and miR-126-5p mediated regulatory mechanisms. This study provides insights for understanding the gene-level regulation of cell growth in tissue engineering.
ADVANCED MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Qin Rao, Ling Weng, Jinshuang Zhang, Donghao Liu, Wenjuan Zhang, Siyuan Chen, Jialong Chen, Xiangyang Li, Hua Qiu, Ying Cao, Quanli Li, Shunli Zheng
Summary: Titanium and its alloys are widely used as implant materials, but implant-associated bacterial infection or inflammation remains a major cause of implantation failure and a global health issue. Superhydrophobic surfaces with high water contact angles have attracted attention for their self-cleaning and low-adhesion properties, and are considered important in preventing biofilm formation.
Article
Biophysics
Jiaojiao Li, Xiaoqin Wu, Zhaojia Liang, Zhangao Wei, Zirui Chen, Yankai Wang, Wei Li, Weibo Zhang, Runhuai Yang, Hua Qiu, Xiangyang Li, Quanli Li, Jialong Chen
Summary: The programmed surface containing silver nanoparticles and silver ions demonstrated sequential antibacterial effects and osseointegration capabilities at different time points. The optimized coating exhibited potent bactericidal activity in the early stage and sustained antibacterial efficacy in subsequent stages, while maintaining good cytocompatibility and promoting bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Xiaoqin Wu, Liqi Li, Wei Tao, Huilei Hong, Lijie Zhang, Shunli Zheng, Runhuai Yang, Quanli Li, Xiangyang Li, Hua Qiu, Jialong Chen
Summary: The purpose of this study was to construct antibacterial coatings on titanium surfaces using layer-by-layer self-assembly technology. The results showed that both coatings inhibited or killed bacteria and prevented plaque biofilm formation. In-vitro and in-vivo experiments demonstrated that the coatings promoted cell adhesion and proliferation and alleviated bacteria-induced inflammation.
BIOMATERIALS ADVANCES
(2023)
Article
Biochemical Research Methods
Shilu Zhu, Yifan Cheng, Jialong Chen, Guangli Liu, Tingting Luo, Runhuai Yang
Summary: Micromotors have shown great potential in various fields and further research on the cooperative and interactive behaviours of multiple micromotors could revolutionize many areas. However, reversible transformations among diverse behaviours have not been well explored and are crucial for achieving complex tasks.
Article
Automation & Control Systems
Yin Chen, Mingliang Li, Qianqian Tang, Yifan Cheng, Anqi Miao, Liang Cheng, Shilu Zhu, Tingting Luo, Guangli Liu, Lijiu Zhang, Fuzhou Niu, Liang Zhao, Jialong Chen, Runhuai Yang
Summary: This study proposes NIR-driven microrobots with high-speed, unidirectional propulsion in high-viscosity liquid. The 3D-printed claw-like microrobot achieves an average speed of 1.4 mm s(-1) in pure glycerol and 54 mm s(-1) in deionized water when driven by NIR light. This work provides new ideas for the design and propulsion of light-driven microrobots in a high-viscosity vivo environment, expanding their potential biomedical applications.
ADVANCED INTELLIGENT SYSTEMS
(2023)