Review
Polymer Science
Elham Pishavar, Fatemeh Khosravi, Mahshid Naserifar, Erfan Rezvani Ghomi, Hongrong Luo, Barbara Zavan, Amelia Seifalian, Seeram Ramakrishna
Summary: Hydrogels, as potential candidates in regenerative medicine, have garnered attention for mimicking native cell-ECM interactions and drug delivery capabilities. The use of self-healing supramolecular hydrogels in preclinical trials offers benefits such as biocompatibility and targeted drug delivery. These highly potential materials address limitations in current drug delivery systems and cater to the high clinical demand for customized drug release systems.
Review
Materials Science, Multidisciplinary
Quanjing Zhu, Chenlan Shen, Rong Chen, Chao Mao, Yong He, Ke Yang
Summary: DNA is a biomacromolecule that can be modified and designed through enzymatic or chemical techniques. It has exceptional ability for selective recognition and structural design, making it an excellent smart material. DNA-based hydrogels have been widely studied in the fields of biosensing and biomedical applications. This review article highlights the construction methods, properties, and applications of DNA-based hydrogels in bioanalysis and therapeutics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Mehdi Azizi, Rana Jahanban-Esfahlan, Hadi Samadian, Masoud Hamidi, Khaled Seidi, Alireza Dolatshahi-Pirouz, Amirhossein Ahmadieh Yazdi, Amin Shavandi, Sophie Laurent, Mahsa Be Omide Hagh, Nahid Kasaiyan, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: In the past three decades, nanoscience has provided a unique solution for reducing the systemic toxicity and increasing therapeutic efficiency of chemotherapy drugs. However, the poor accumulation and pharmacokinetics of nanoparticles hinder their translation into clinical use. New findings suggest that the efficacy based on enhanced permeability and retention may be as low as 1%. This review focuses on the current barriers, available solutions, and strategies for efficient drug delivery using nanocarriers and the tumor environment.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Joanna Skopinska-Wisniewska, Silvia De la Flor, Justyna Kozlowska
Summary: Supramolecular hydrogels are water-swelled materials held together by reversible, non-covalent interactions, offering unique properties and potential applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mercedeh Babaluei, Yasamin Mojarab, Subhas C. Kundu
Summary: Skin injuries, especially chronic wounds, remain a significant healthcare problem. Recent developments in multifunctional wound dressings aim to improve wound repair.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Integrative & Complementary Medicine
Xiaoqing Zhong, Zhenning Di, Yuanxin Xu, Qifan Liang, Kuanhan Feng, Yuting Zhang, Liuqing Di, Ruoning Wang
Summary: Mineral drugs are an important part of traditional Chinese medicine, but their safety and scientific nature are controversial due to heavy metals and strong toxicity. The development of nanomedicine offers promising prospects for mineral drug delivery, although research on mineral drug delivery systems is currently limited.
Article
Biochemistry & Molecular Biology
Giuseppe Cirillo, Elvira Pantuso, Manuela Curcio, Orazio Vittorio, Antonella Leggio, Francesca Iemma, Giovanni De Filpo, Fiore Pasquale Nicoletta
Summary: The study successfully integrated electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate to create multifunctional materials with features including tolerance by human cells, changes in swelling properties, and pH and electro-responsive behavior.
Article
Chemistry, Multidisciplinary
Lin Jing, Li-Yin Hsiao, Shuo Li, Haitao Yang, Patricia Li Ping Ng, Meng Ding, Tien Van Truong, Si-Ping Gao, Kerui Li, Yong-Xin Guo, Pablo Valdivia y Alvarado, Po-Yen Chen
Summary: Soft robotic skins based on 2D materials and gelatin hydrogels were developed for multifunctionality in harsh environments. By incorporating different 2D materials, the skins enabled robots to work in high heat, open fire, electromagnetic radiation, and biocontamination. Furthermore, blending materials allowed for strain sensitivity and high-level integration of skin-mimicking capabilities in robots.
MATERIALS HORIZONS
(2021)
Article
Chemistry, Multidisciplinary
Wen Zhang, Wenqi Liu, Linyu Long, Shuyi He, Zhicun Wang, Yang Liu, Li Yang, Ningbo Chen, Cheng Hu, Yunbing Wang
Summary: The harsh microenvironment and poor tissue regeneration ability of chronic diabetic wounds make them difficult to cure. A new approach using smart-responsive multi-functional hydrogels has been developed to improve the healing of such wounds. These hydrogels can quickly respond to the acidic environment of diabetic wounds and release multiple drugs in a sequential manner. In vitro and in vivo experiments have shown that these hydrogels effectively eliminate bacteria, relieve inflammation, and promote angiogenesis, thereby accelerating the closure of chronic diabetic wounds.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Carolina Amorim, Sergio R. S. Veloso, Elisabete M. S. Castanheira, Loic Hilliou, Renato B. Pereira, David M. Pereira, Jose A. Martins, Peter J. Jervis, Paula M. T. Ferreira
Summary: In this study, four symmetrical bolaamphiphiles based on dehydrodipeptides were prepared and their self-assembly properties were investigated. The results showed the bolaamphiphiles can form self-standing hydrogels and provide sustained release. These hydrogelators are non-toxic to cells and have an elastic modulus similar to native tissues.
Article
Polymer Science
Yiluo Hu, Younghyun Shin, Sohyun Park, Jae-pil Jeong, Yohan Kim, Seunho Jung
Summary: Self-healing and temperature/pH-responsive hydrogels were prepared by using oxidized succinoglycan (OSG) and a poly (N-isopropyl acrylamide-co-acrylamide) [P(NIPAM-AM)] copolymer. OSG, synthesized from succinoglycan (SG) isolated directly from soil microorganisms, showed improved elasticity, thermal stability, self-healing ability, and tensile strength compared to P(NIPAM-AM) hydrogels. The OSG/P(NIPAM-AM) hydrogels also exhibited effective temperature/pH-responsive drug release and non-toxicity, suggesting their potential for biomedical applications such as drug delivery systems, wound healing, scaffolds, and tissue engineering.
Article
Materials Science, Multidisciplinary
Wenhuan Wang, Lin Sang, Yiping Zhao, Zhiyong Wei, Min Qi, Yang Li
Summary: The study reported on radiopaque drug-eluted beads as promising embolic materials for TACE techniques, demonstrating good anti-tumor effects and radiopacity, with potential application in HCC and other cancer therapies.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Kaixiang Shen, Kai Xu, Mengyuan Zhang, Jing Yu, Yuxuan Yang, Xiaodan Zhao, Qiang Zhang, Youshen Wu, Yangfeng Zhang, Yilong Cheng
Summary: Ion-conductive hydrogels have vast potentials in wearable electronic devices, human-machine interfaces, and health monitoring. In this work, an IC hydrogel sensor with high mechanical properties and excellent sensing performance was developed using N-acryloyl phenylalanine, which can be used for monitoring human body movements and sleep quality.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Pedro Gontijo Carneiro, Duane Gischewski Pereira, Bruno Milton Oliveira da Silva, Helio Ribeiro, Leandro Augusto Barbosa, Jose Augusto Ferreira Perez Villar, Mariane Cristina Schnitzler
Summary: The main issues with antitumor chemotherapy are the non-specific and systemic toxicity induced by different drugs. Tumor cells' ability to hinder the internalization and metabolism of chemotherapy drugs also affects the efficacy of antitumoral therapies. This study focuses on the synthesis and evaluation of a dual drug delivery system based on non-covalent functionalization, using multi-walled carbon nanotubes (MWCNT) as vectors conjugated with folic acid (FA) for targeted delivery and enhanced bioavailability, and incorporating digoxin (DGX) as a cytotoxic agent. The study demonstrates the potential of this rational drug delivery system, showing significant cytotoxicity to tumor cells while avoiding acute toxicity associated with MWCNT.
SURFACES AND INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Weiwei Xin, Yingjian Gao, Bing Yue
Summary: This review article discusses the use of hydrogel-based strategies for the treatment of osteomyelitis. These strategies possess unique properties such as loadable, implantable, injectable, printable, degradable, and responsive to stimuli, which have the potential to improve biological properties including antimicrobial effects, osteo-induction, and controlled drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zi-Long Song, Yun Zhu, Jing-Rui Liu, Shu-Ke Guo, Yu-Cheng Gu, Xinya Han, Hong-Qiang Dong, Qi Sun, Wei-Hua Zhang, Ming-Zhi Zhang
Summary: Through diversity-oriented synthesis strategy, two series of novel pimprinine derivatives containing 1,3,4-oxadiazole-5-thioether moieties were efficiently synthesized under optimized conditions. Biological assays showed potential activity in designed derivatives, with one compound demonstrating strong antifungal activity. Further structural optimization is ongoing to discover synthetic analogues with improved antifungal activity.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Multidisciplinary
Xinyi Huang, Hui Zhou, Xiaojun Yue, Songlin Ran, Jianhua Zhu
Summary: Magnetic Fe3O4/alpha-FeOOH heterojunction nanocomposites (Fe-NCs) were synthesized by a fast one-pot hydrothermal method, exhibiting excellent degradation and mineralization of tetracycline in the visible photoFenton reaction. Different phases in the composites enhance visible-light absorption, improve separation and transfer of photogenerated electron-hole pairs, and contribute to high catalytic efficiency. The high production of photogenerated holes and superoxide radicals in Fe-NCs is favorable to the degradation of tetracycline.
Article
Chemistry, Medicinal
Wuqiang Wen, Hongxuan Cao, Yunyuan Huang, Jie Tu, Chen Wan, Jian Wan, Xinya Han, Han Chen, Jiaqi Liu, Li Rao, Chen Su, Chao Peng, Chunquan Sheng, Yanliang Ren
Summary: This study identifies a new covalent allosteric site of Candida albicans' Fructose-1,6-bisphosphate aldolase and discovers the first generation of covalent inhibitors for fungal FBA. These inhibitors also exhibit good inhibitory activity against azole-resistant fungi.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qian Chen, Yudie Sun, Shengjun Liu, Jian Zhang, Cheng Zhang, Hui Jiang, Xinya Han, Lifang He, Suhua Wang, Kui Zhang
Summary: Organophosphorus compounds, including nerve agents and pesticides, are toxic organic phosphorus molecules with significant applications in agriculture and detection. Colorimetric and fluorescence sensors have been widely studied for rapid, sensitive, and convenient detection of organophosphorus analogs.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Yanggen Hu, Chao Luo, Lili Gui, Jing Lu, Juncai Fu, Xinya Han, Junkai Ma, Lun Luo
Summary: A Schiff base FPS based on simplefuro[2,3-d]pyrimidinone was synthesized and found to exhibit selective fluorescence sensing behavior towards Zn2+ ions, while FPS-Zn2+ could also serve as a highly selective and sensitive chemosensor for Cu2+ ions.
FRONTIERS IN CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Anqi Ni, Danni Fu, Peng Lin, Youyi Xia, Dejian Pei, Xinya Han, Shaoguang Hua, Shuqin Li, Tingting Zhang
Summary: A porous photothermal hydrogel coating with excellent water transportation capacity, high evaporation performance, and stability has been developed for solar-driven water purification.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Huan Qin, Xiaolong Ding, Shi-Qi Cheng, Si-Yong Qin, Xinya Han, Yue Sun, Yi Liu
Summary: In this study, an artificial nanochannel with a conductance value of 2.01 nS was successfully fabricated using a supramolecular coordination strategy. Utilizing the unique H2S-mediated covalent reaction, the nanochannel biosensor was able to switch from ON to OFF states upon the addition of H2S. Furthermore, the nanochannel exhibited high rectification ratio and gating ratio, directing ion transport. Theoretical simulations were conducted to provide insights into the possible mechanism of the functionalized nanochannel.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Ceramics
Jianhua Zhu, Xiaojun Yue, Dong Wang, Xing Jin, Songlin Ran
Summary: TiB2-TiC-SiC composites were prepared through reactive spark plasma sintering, exhibiting integrated high strength and high toughness.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Engineering, Chemical
Jianhua Zhu, Hui Zhou, Rui Wang, Chen Wang
Summary: The core-shell NS@MIL-101(Fe) heterojunctions were synthesized through a solvothermal method, which exhibited hierarchical structures and enhanced degradation efficiency towards Orange II. This study provides a new strategy for the design of MOF-based photocatalysts.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Chemistry, Medicinal
Jing-Rui Liu, Ya Gao, Bing Jin, Dale Guo, Fang Deng, Qiang Bian, Hai-Feng Zhang, Xin-Ya Han, Abdallah S. Ali, Ming-Zhi Zhang, Wei-Hua Zhang, Yu-Cheng Gu
Summary: Based on natural products streptochlorin and pimprinine, a series of streptochlorin derivatives with nitrile group were synthesized. The most promising candidate, compound 3a, demonstrated over 85% growth inhibition against several fungi and displayed a broad antifungal spectrum. Structure-activity relationship analysis revealed that non-substituted or alkyl-substituted oxazole ring at the 2-position favored antifungal activity, while aryl and monosubstituted aryl were detrimental. Molecular docking models indicated that 3a formed interactions with Leucyl-tRNA Synthetase, providing insight into its mechanism of action.
Article
Chemistry, Analytical
Qian Chen, Jiaxu Liu, Shengjun Liu, Jian Zhang, Lifang He, Renyong Liu, Hui Jiang, Xinya Han, Kui Zhang
Summary: Chemical nerve agents are toxic compounds that can be used by terrorists to threaten security and safety. A colorimetric and fluorescent probe has been developed to detect specific chemical nerve agents in solution and vapor. The detection mechanism involves the reaction between the probe and the nerve agent, resulting in fluorescent changes. The probe can also be used for visual detection of nerve agents.
ANALYTICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Jufen Yan, Pei Wang, Longxin Wang, Qi Jin, Abdallah S. Ali, Yongsheng He, Ying Wang, Yuxuan Sun, Aoqiang Li, Waly Adwy, Rasha H. Ahmed, Xinya Han
Summary: This study utilized the endophytic fungus Penicillium janthinellum LM5 for the biosorption of synthetic dyes. It was found that LM5 formed efficient mycelium particles and showed good decolorization performance in dye solutions. The fungus also exhibited effective decolorization even under high salt concentrations. These results indicate that LM5 has potential as a biomaterial for dye wastewater treatment.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Agronomy
Lan Cheng, Jing-Rui Liu, Jia-Mu Liu, Dale Guo, Fang Deng, Qiang Bian, Haifeng Zhang, Xinya Han, Abdallah S. Ali, Wei-Hua Zhang, Ming-Zhi Zhang, Yu-Cheng Gu
Summary: In this study, we developed and synthesized ring-opening derivatives of pimprinine containing amide/thioamide, and evaluated their antifungal activity against six common plant pathogenic fungi. Our results showed that compound 3o exhibited pronounced antifungal effects, with high inhibition rates and low effective concentrations. Furthermore, docking studies revealed the potential antifungal mechanism of compound 3o. Overall, the optimized derivative 3o of ring-opening pimprinine is a promising candidate for further research as a new antifungal drug.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Organic
Yiliang Chen, Wenwen Pan, Xiaolong Ding, Liang Zhang, Qinfei Xia, Qi Wang, Qian Chen, Qinghe Gao, Jufen Yan, Roman Lesyk, Zilong Tang, Xinya Han
Summary: A series of novel nitrobenzoxadiazole-piperazine hybrids were designed, synthesized, and evaluated for their anticancer activities. The hybrids 3u, 3v, and 3w with a chloromethyl substitution exhibited the most potent anticancer effects. Compound 3u triggered apoptosis in cancer cell lines through hydrolyzing of PARP and effectively inhibited colony formation. Compound 3u shows potential as a promising lead compound for discovering novel antitumor agents.
Article
Chemistry, Organic
Qinghe Gao, Zhenhua Sun, Manman Wu, Yimei Guo, Xinya Han, Jufen Yan, Minh Ngoc Ha, Quynh Mai Le, Yongtao Xu
Summary: An unexpected oxidative radical cyclization reaction of 3(5)-aminoazoles and aromatic aldehydes with di-tert-butyl peroxide (DTBP) is described in this article. This reaction protocol enables the efficient synthesis of privileged 7-methylpyrazolo[1,5-a]pyrimidines and 7-methyl-[1,2,4]triazolo[1,5-a]pyrimidines with excellent regioselectivity and functional group tolerance. The reaction is also highlighted for its potential for late-stage modifications of natural products and pharmaceuticals.
ORGANIC CHEMISTRY FRONTIERS
(2022)
