Article
Food Science & Technology
Arpan Singha Deo, P. J. Asheela Devi, K. S. Sijisha, R. Anusha, Tripti Mishra, Siby Mathew, K. Mathew Abraham, R. Jagadish, S. Priya
Summary: The study compared the antioxidant, anticancer, and anti-inflammatory activities of green tea, orthodox black tea, and CTC black tea. The results showed that green tea had higher antioxidant and anticancer activities and exhibited the best anti-inflammatory effects.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Veterinary Sciences
Amany M. Ramez, Ehab Kotb Elmahallawy, Gehad E. Elshopakey, Amira A. Saleh, Samar M. Moustafa, Ashraf Al-Brakati, Walied Abdo, Dina M. M. El-Shewehy
Summary: The combined treatment with Spirulina platensis and matcha green tea showed effective therapeutic effects in Schistosoma mansoni-infected mice. It reduced liver damage, enhanced antioxidant capacity, suppressed inflammatory response, and improved tissue structure. Further research is recommended to explore the mechanisms of this combined treatment for developing novel therapies against the disease.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Analytical
Hideto Kimura, Shota Tokuyama-Nakai, Yu Hirabayashi, Tomoe Ishihara, Mitsuo Jisaka, Kazushige Yokota
Summary: The study showed that TMF-O-glycosides and free TMF from indigo plants have anti-inflammatory activities, and protected against ulcerative colitis in a murine model. The findings suggest that dietary TMF-O-glycosides could be promising natural sources for herbal medicine and nutraceuticals with in vivo anti-inflammatory activities.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Chemistry, Medicinal
Chong Li, Jianchun He, Yue Yang, Yuting Gou, Zhiying Wang, Hong Chen, Xin Zhao
Summary: White tip silver needle, a slightly fermented white tea abundant in flavonoids, shows strong antioxidant and anti-inflammatory properties, effectively reducing organ damage and oxidative inflammatory reactions in aging mice induced by D-galactose/lipopolysaccharide.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Kai On Chu, Kwok Ping Chan, Yolanda Wong Ying Yip, Wai Kit Chu, Chi Chiu Wang, Chi Pui Pang
Summary: The study showed that GTE indirectly induced systemic phosphorylcholine lipids to suppress inflammatory responses, hepatic damage, and respiratory mitochondrial stress in EIU rats induced by LPS. Phospholipids may be a therapeutic target of GTE for anterior chamber inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Piotr Olcha, Anna Winiarska-Mieczan, Malgorzata Kwiecien, Lukasz Nowakowski, Andrzej Miturski, Andrzej Semczuk, Bozena Kiczorowska, Krzysztof Galczynski
Summary: Endometrial cancer (EC) is a commonly diagnosed malignant tumor in the female reproductive system. Literature suggests that 32 genes are involved in the hereditary incidence of EC. The physiological markers of EC include disorders in the antioxidative system and inflammation. A diet rich in substances aiding the response to this disorder, particularly those suitable for lifelong consumption, is important for prophylaxis and pharmacotherapy. Tea polyphenols have proven antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties, making tea consumption beneficial for individuals genetically predisposed for EC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiko Nakadate, Kiyoharu Kawakami, Noriko Yamazaki
Summary: Chronic obesity leads to various diseases, highlighting the urgency for treatment and prevention. This study investigated the combined effects of tea catechins and beta-cryptoxanthin from mandarin oranges on reducing obesity using obese mice induced by monosodium glutamate. The results showed that the mice consuming both tea catechins and beta-cryptoxanthin for 4 weeks experienced a significant decrease in body weight, with no difference compared to control mice. In addition, blood biochemical tests were normal, and histopathological analysis indicated a decrease in body fat percentage. Moreover, the abundance of pro-inflammatory M1 macrophages in adipose tissue was significantly reduced, while beneficial M2 macrophages increased and adiponectin levels, involved in suppressing metabolic syndrome, were elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vishu Chaudhary, Priya Katyal, Harsh Panwar, Jaspreet Kaur, Rotimi E. Aluko, Anil Kumar Puniya, Anuj Kumar Poonia
Summary: This study evaluated the therapeutic potential of a red biopigment extracted from Monascus purpureus using solid-state fermentation on human prostate LNCaP cells. The biopigment demonstrated strong antioxidant and anti-inflammatory effects, as well as cytotoxicity against cancer cells, making it a promising supplement for the treatment of inflammatory-related diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Lin Wang, Ting Feng, Zhilian Su, Chao Pi, Yumeng Wei, Ling Zhao
Summary: Baicalin and baicalein, derived from Scutellaria baicalensis Georigi, have remarkable anticancer activities by inducing apoptosis, cell cycle arrest, suppressing metastasis, inducing autophagy, and regulating immunity. Baicalein shows quicker and stronger inhibitory effects on multiple cancers compared to baicalin, possibly due to its smaller size and high lipophilicity.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Food Science & Technology
Sarah Auguste, Bing Yan, Maolin Guo
Summary: Polyphenols found in tea can induce mitophagy in human fibroblast cells, and the induction of mitophagy may play an important role in the anti-aging mechanism of tea.
Review
Chemistry, Medicinal
Javier Avila-Roman, Sara Garcia-Gil, Azahara Rodriguez-Luna, Virginia Motilva, Elena Talero
Summary: Acute inflammation is a key part of the immune system's response, but uncontrolled acute inflammation may lead to chronic inflammation and the development of diseases like cancer. Microalgal carotenoids are considered rich sources of bioactive molecules, with beneficial effects for health, including anti-inflammatory and anticancer activities.
Article
Food Science & Technology
Van-Long Truong, Woo-Sik Jeong
Summary: Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea polyphenols have established antioxidant and anti-inflammatory properties, and their supplementation can prevent inflammatory conditions and improve the outcome of patients with inflammatory bowel diseases (IBD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Yue-Dong Yue, Zhi-Nan Xiang, Jia-Chun Chen
Summary: A new phenolic glycoside and a new megastigmane glycoside were isolated from Alangium chinense roots, along with twelve known compounds. In vitro anti-inflammatory activity of these compounds was evaluated, with compound 1 showing stronger activity than Triptolide.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Igor A. Schepetkin, Mark B. Plotnikov, Andrei Khlebnikov, Tatiana M. Plotnikova, Mark T. Quinn
Summary: Oximes have diverse pharmaceutical properties and can act as kinase inhibitors, antimicrobials, anticancer agents, anti-arthritis drugs, and anti-stroke medications. Their functional group structure allows for a different mode of interaction with receptor binding sites compared to carbonyl compounds.
Article
Food Science & Technology
Seul Ki Yoo, Jin Yong Kang, Uk Lee, Seon Kyeong Park, Jong Min Kim, Hye Ju Han, Dae Ok Kim, Ho Jin Heo
Summary: The study found that EFAL can improve cognitive decline caused by hyperglycemia by reducing oxidative stress and suppressing the decrease of neurotransmitters.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Kwan Joong Kim, Young Sung Jung, Dong Min You, Seung Hyun Lee, Guemsan Lee, Kang-Beom Kwon, Dae-Ok Kim
Summary: In this study, Rhodiola rosea L. rhizome was authenticated and its neuroprotective effects were investigated. The results indicated that Rhodiola rosea L. rhizome and its bioactive compounds showed potential for protecting neuronal cells.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng, Ho Jin Heo, Ji-Ho Park, Dae-Ok Kim
Summary: This study found that EGCG can alleviate scopolamine-induced learning and memory impairments and improve brain function. This may be achieved through mechanisms such as improving cholinergic function and reducing oxidative stress.
Article
Chemistry, Applied
Mi-Seon Kim, Young Sung Jung, Davin Jang, Chi Heung Cho, Sang-Hoon Lee, Nam Soo Han, Dae-Ok Kim
Summary: This study evaluated the antioxidant capacity, bioaccessibility, and bioavailability of 12 soy isoflavones (SIs). The results showed that SIs were stable under gastric digestion conditions but unstable under small intestinal digestion conditions for acetyl and malonyl conjugates. SI aglycones had higher permeability and cellular accumulation than their glucosides. A small amount of intact SI conjugates were found in the cell and in the basolateral side of each Transwell.
Article
Food Science & Technology
Briana M. Nosal, Junichi R. Sakaki, Dae-Ok Kim, Ock K. Chun
Summary: The brewing methods and types of coffee can affect the antioxidant capacity of coffee consumers, with capsule coffee showing higher total phenolic content and antioxidant capacity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Eun-Sang Hwang, Ga-Young Choi, Kwan Joong Kim, Min-Jeong Kim, Seok Lee, Jin-Won Lee, Dae-Ok Kim, Ji-Ho Park
Summary: Vitamin C (VC) can lower blood pressure in spontaneously hypertensive rats (SHRs) by directly targeting ACE I production and may improve endothelial function, with the frequency of administration affecting its effectiveness.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Using amylosucrase from Deinococcus geothermalis, alpha-linked glucosylation of Soybean isoflavone aglycones (SIAs) was achieved, resulting in 13 alpha-linked glucosyl SIAs with confirmed colors in solution. The structures of the compounds were identified using mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The study suggests a strategy for the synthesis of bioactive compounds with enhanced water solubility through alpha-linked glucosylation, with the products attached to the C-4 ' of SIAs found to be more water-soluble than those attached to the C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kwan Joong Kim, Eun-Sang Hwang, Min-Jeong Kim, Chan-Su Rha, Myoung Chong Song, Sungho Maeng, Ji-Ho Park, Dae-Ok Kim
Summary: The study demonstrated the cognitive-enhancing effect of Pinus densiflora Sieb. et Zucc. bark extract (PBE). PBE improved cognitive impairment in rats through its antioxidant properties and enhancement of long-term potentiation (LTP) induction in organotypic hippocampal slices.
Article
Chemistry, Applied
Chan-Su Rha, Eun Kyu Jang, Jong Suk Lee, Ji-Sung Kim, Min-Ji Ko, Sol Lim, Gun Hwan Park, Dae-Ok Kim
Summary: A study was conducted on the chemical constituents of soybean leaves and their correlations across phenotypes, growing periods, and cultivation areas using targeted metabolomics and machine learning models. The distribution of isoflavones and flavonols was found to be influenced by the growing period and cultivation area, and the neural network model showed the best predictive capacity for the differences in soybean leaves.
Article
Food Science & Technology
Ga-Young Choi, Kwan Joong Kim, Ho-Sub Park, Eun-Sang Hwang, Jae-Min Cho, Hyun-Bum Kim, Dae-Ok Kim, Ji-Ho Park
Summary: The study investigated the potential anti-atopic dermatitis (AD) effects of a herbal combination of Lithospermum erythrorhizon (LE), Houttuynia cordata (HC), and Spirodela polyrhiza (SP). Through ultra-high-pressure liquid chromatography (UHPLC)-Orbitrap mass spectrometer (MS), a total of 42 compounds were identified in LE, HC, SP, and the combined herb extract of LE, HC, and SP (LHS). The LHS showed increased concentration of flavonoid glycosides compared to individual extracts, and effectively inhibited the key characteristics of AD such as epidermal thickness increase, mast cell proliferation, and immunoglobulin E release.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Young Sung Jung, Hyunbin Seong, Nam Soo Han, Dae-Ok Kim
Summary: Soybean is an important crop and a significant dietary source of isoflavones. Understanding the bioaccessibility and bioavailability of soy isoflavones is crucial for comprehending their bioactivities. This review evaluates reports using in vitro methods to study the bioavailability of soy isoflavones and discusses how their molecular structures influence their bioactivities.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Eun-Ha Park, Inil Lee, Gi-Cheol Park, Seung-Ju Lee, Kwan Joong Kim, Jisuk Yun, Dae-Ok Kim
Summary: Canola meal, a by-product of canola oil processing, has antioxidant and skin anti-aging effects. This is due to the bioactive compounds found in canola meal, particularly the antioxidative phenolics present in canola meal extract (CME).
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Soybean isoflavone aglycones (SIAs) have low water solubility in the human body. By glycosylation, SIAs can obtain structural diversity and change their physicochemical properties, including water solubility. The alpha-linked glucosylation of SIAs was achieved using amylosucrase from Deinococcus geothermalis. 13 alpha-linked glucosyl SIAs were obtained and their structures were identified by mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The glucosylated SIAs attached to C-4' were found to be more water-soluble than those attached to C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Min Young Um, Minseok Yoon, Minji Kim, Jonghoon Jung, Seonghui Kim, Dae-Ok Kim, Suengmok Cho
Summary: This study aimed to investigate the effects and underlying mechanisms of curcuminoids and their constituents on the sleep-wake cycle of mice. The results showed that curcuminoids reduced sleep latency and increased sleep duration by interacting with H1R. These findings suggest the potential importance of curcuminoids in treating insomnia.
