MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities

Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function

(2019) Munehiro Kitada et al.   Frontiers in Endocrinology

MicroRNAs as regulators of mitochondrial dysfunction and obesity

(2018) Mora Murri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intravenous Injection of miR-34a Inhibitor Alleviates Diabetes Mellitus-Induced Vascular Endothelial Dysfunction by Targeting NOTCH1

(2018) Di Zhao et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy

(2018) Ana R. Santiago et al.   Frontiers in Physiology

The effects of microRNAs in activating neovascularization pathways in diabetic retinopathy

(2018) Mahbobeh Satari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling

(2017) Ying Lin et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

MicroRNA Regulation of Oxidative Stress

(2017) Jaideep Banerjee et al.   Oxidative Medicine and Cellular Longevity

Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

(2017) Menaka C. Thounaojam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs

(2017) Huaping Zhang et al.   TOXICOLOGY LETTERS

Alternative mechanisms of miR-34a regulation in cancer

(2017) Eva Slabáková et al.   Cell Death & Disease

miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus

(2017) Yanxin Shen et al.   Experimental and Therapeutic Medicine

MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2

(2017) Fan Fan et al.   Oncotarget

Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes

(2017) Madhu Khullar et al.   Frontiers in Endocrinology

Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs

(2016) Bianca C. Bernardo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

(2016) Yujia Yuan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs

(2016) Xiao-Feng Tian et al.   PLoS One

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-34 Family and Its Role in Cardiovascular Disease

(2015) Na Li et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

MiR-34a regulates blood–brain barrier permeability and mitochondrial function by targeting cytochrome c

(2015) Mimi Bukeirat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Increased Oxidative and Nitrative Stress Accelerates Aging of the Retinal Vasculature in the Diabetic Retina

(2015) Folami Lamoke et al.   PLoS One

Intermittent High Glucose Implements Stress-Induced Senescence in Human Vascular Endothelial Cells: Role of Superoxide Production by NADPH Oxidase

(2015) Morihiko Maeda et al.   PLoS One

Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

(2014) Kento Kitada et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors

(2014) Ileana Badi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives

(2014) Ying Wu et al.   Oxidative Medicine and Cellular Longevity

Role of microRNAs in the modulation of diabetic retinopathy

(2014) Rodolfo Mastropasqua et al.   PROGRESS IN RETINAL AND EYE RESEARCH

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

MnSOD in Oxidative Stress Response-Potential Regulation via Mitochondrial Protein Influx

(2013) Demet Candas et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

(2013) Rokhsana Mortuza et al.   PLoS One

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence

(2012) HouZao Chen et al.   Science China-Life Sciences

MiR-34, SIRT1, and p53: The feedback loop

(2011) Munekazu Yamakuchi et al.   CELL CYCLE

Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

(2011) Q. Zhong et al.   DIABETES

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

(2011) X.-Y. Bai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

(2010) Lei Kong et al.   ACTA DIABETOLOGICA

MicroRNA-34a regulation of endothelial senescence

(2010) Takashi Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA