Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways

Cardiac glycoside Cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

(2019) Md Shahadat Hossan et al.   CANCER LETTERS

Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell

(2018) Yudong Hu et al.   BIOCHEMICAL PHARMACOLOGY

C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells

(2018) Liangqian Jiang et al.   Cancer Cell International

Triple negative breast cancer in Asia: An insider’s view

(2018) Chao Wang et al.   CANCER TREATMENT REVIEWS

Discovery of selective dengue virus inhibitors using combination of molecular fingerprint-based virtual screening protocols, structure-based pharmacophore model development, molecular dynamics simulations and in vitro studies

(2018) Shaher Bano Mirza et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells

(2018) Jong Hyun Lee et al.   PHYTOMEDICINE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ganoderic acid A exerts antitumor activity against MDA‑MB‑231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

(2018) Yuguang Yang et al.   Oncology Letters

Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound

(2018) Tareq Abu-Izneid et al.   Biomed Research International

Anti-Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres

(2017) Vivek Kaushik et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anticancer and Immunogenic Properties of Cardiac Glycosides

(2017) Naira Schneider et al.   MOLECULES

Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo

(2017) Mahmoud Hashemzaei et al.   ONCOLOGY REPORTS

Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells

(2017) Lei Xue et al.   Oncology Letters

Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer

(2017) S-U Woo et al.   Oncogenesis

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

(2017) Min-Wu Chao et al.   Scientific Reports

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status

(2016) Irem Durmaz et al.   PHYTOMEDICINE

Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells

(2016) Chung-Weng Phang et al.   PLoS One

Mapping signaling pathway cross-talk inDrosophilacells

(2016) Noemie Ammeux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair

(2016) Mi Ae Kang et al.   Oncotarget

High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

(2015) Elpetra P. M. Timmermans-Sprang et al.   BMC CANCER

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

(2015) Diogo Gomes Garcia et al.   Molecular Cancer

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

(2015) M Buchert et al.   ONCOGENE

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Natural Bioactives in Cancer Treatment and Prevention

(2015) Yih-Shou Hsieh et al.   Biomed Research International

6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways

(2015) Sung-Moo Kim et al.   MOLECULAR CARCINOGENESIS

Antiviral activity of lanatoside C against dengue virus infection

(2014) Yan Yi Cheung et al.   ANTIVIRAL RESEARCH

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity

(2014) Sailu Sarvagalla et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells

(2014) Mohammad Ali Esmaeili et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Role of Cardiotonic Steroids in the Pathogenesis of Cardiomyopathy in Chronic Kidney Disease

(2014) Davor Pavlovic   NEPHRON CLINICAL PRACTICE

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

Drug Therapy for Advanced-Stage Liver Cancer

(2014) Markus Peck-Radosavljevic   Liver Cancer

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

(2014) Sarah Walker et al.   Cancers

Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling

(2013) A. Schroeder et al.   CANCER RESEARCH

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

(2013) Shun-Fa Yang et al.   Evidence-based Complementary and Alternative Medicine

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS

(2013) Chern Chiuh Woo et al.   PLoS One

Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance

(2013) Adrienne L. Watson et al.   Cancer Discovery

Wnt/β-Catenin Signaling Pathway Upregulates c-Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells

(2012) Shuai Zhang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

(2012) Claudia Cerella et al.   MITOCHONDRION

FASCAPLYSIN as a Specific Inhibitor for CDK4: Insights from Molecular Modelling

(2012) Muhammad Imtiaz Shafiq et al.   PLoS One

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor–related apoptosis-inducing ligand and induces an alternative cell death pathway

(2011) Christian E. Badr et al.   NEURO-ONCOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

(2010) Rui Huang et al.   ASIAN JOURNAL OF ANDROLOGY

Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation

(2010) Fengxiang Wei et al.   CELLULAR SIGNALLING

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

(2009) Andrea Perne et al.   PLoS One

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY