p38-Mitogen Activated Kinases Mediate a Developmental Regulatory Response to Amino Acid Depletion and Associated Oxidative Stress in Mouse Blastocyst Embryos

Mitochondria in early development: linking the microenvironment, metabolism and the epigenome

(2019) Alexandra J Harvey   REPRODUCTION

Origins of lifetime health around the time of conception: causes and consequences

(2018) Tom P Fleming et al.   LANCET

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

(2018) Sarah Bowling et al.   Nature Communications

15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms

(2018) Peter V Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code

(2017) Milica Vučetić et al.   Frontiers in Oncology

Lineage specification in the mouse preimplantation embryo

(2016) Claire Chazaud et al.   DEVELOPMENT

Inhibition of mTOR induces a paused pluripotent state

(2016) Aydan Bulut-Karslioglu et al.   NATURE

p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development

(2016) Vasanth Thamodaran et al.   Open Biology

Epigenetic regulation of histone modifications and Gata6 gene expression induced by maternal diet in mouse embryoid bodies in a model of developmental programming

(2015) Congshan Sun et al.   BMC DEVELOPMENTAL BIOLOGY

Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo’s potential, affecting adult health

(2015) Tom P. Fleming et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst

(2015) Tristan Frum et al.   TRENDS IN GENETICS

The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent

(2015) Aleksandar I. Mihajlović et al.   Scientific Reports

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade

(2015) Juan F. Linares et al.   Cell Reports

MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation

(2014) Enrico Desideri et al.   Autophagy

Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition

(2014) C. Sun et al.   DEVELOPMENT

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival

(2013) ROSANNA PARENTE et al.   ONCOLOGY REPORTS

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

(2012) Jose Félix Moruno-Manchón et al.   BIOCHEMICAL JOURNAL

FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse

(2012) M. Kang et al.   DEVELOPMENT

Metabolism of the preimplantation embryo: 40 years on

(2012) Henry J Leese   REPRODUCTION

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes

(2011) Álvaro Gutiérrez-Uzquiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation

(2011) Xiao-Nan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Regulation of autophagy by p38α MAPK

(2010) Jemma L. Webber   Autophagy

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

(2010) Y. Yamanaka et al.   DEVELOPMENT

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

(2010) K. K. Niakan et al.   GENES & DEVELOPMENT

Differential activation of p38MAPK isoforms by MKK6 and MKK3

(2009) Gaëlle Remy et al.   CELLULAR SIGNALLING

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

(2009) J. Nichols et al.   DEVELOPMENT

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1

(2009) M. Cully et al.   MOLECULAR AND CELLULAR BIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

ERK and p38 pathways regulate amino acid signalling

(2008) Eduard Casas-Terradellas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH