Transforming growth factor-β promotes basement membrane fibrosis, alters perivascular cerebrospinal fluid distribution, and worsens neurological recovery in the aged brain after stroke

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

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Increased CD68/TGFβ Co-expressing Microglia/ Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys

(2019) Hyeon-Gu Yeo et al.   Experimental Neurobiology

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

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Fibronectin induces the perivascular deposition of cerebrospinal fluid–derived amyloid-β in aging and after stroke

(2018) Matthew D. Howe et al.   NEUROBIOLOGY OF AGING

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

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Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

Old Maids: Aging and Its Impact on Microglia Function

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The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

(2017) Michelle E. Pizzo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

(2017) Jun-Xia Zhang et al.   MOLECULES

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

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Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

(2017) Zoltan Ungvari et al.   GeroScience

Perlecan Domain V Inhibits Amyloid-β Induced Activation of the α2β1 Integrin-Mediated Neurotoxic Signaling Cascade

(2016) Christi L. Parham et al.   JOURNAL OF ALZHEIMERS DISEASE

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

(2016) Roslyn A. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Relating conformation to function in integrin α5β1

(2016) Yang Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in the cellular immune system and circulating inflammatory markers of stroke patients

(2016) Chao Jiang et al.   Oncotarget

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

(2015) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia

(2015) Qijuan Huang et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

(2014) Egle Cekanaviciute et al.   GLIA

Juvenile Traumatic Brain Injury Induces Long-Term Perivascular Matrix Changes Alongside Amyloid-Beta Accumulation

(2014) Amandine Jullienne et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

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Sleep Drives Metabolite Clearance from the Adult Brain

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Genomic Analysis of Reactive Astrogliosis

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Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease

(2012) Fabiane L. de Oliveira et al.   PLoS Neglected Tropical Diseases

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Functional recovery in aging mice after experimental stroke

(2011) Bharti Manwani et al.   BRAIN BEHAVIOR AND IMMUNITY

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

(2010) Kristian P Doyle et al.   Journal of Neuroinflammation

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

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