Structural studies and cytotoxicity assays of “aggregation-prone” IAPP8-16and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin

Structural studies of “aggregation-prone” peptide-analogues of teleostean egg chorion ZPB proteins

(2014) Nikolaos N. Louros et al.   BIOPOLYMERS

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

(2014) Marianna Flora Tomasello et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy

(2014) Hiren R. Patel et al.   Journal of Physical Chemistry Letters

Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP

(2013) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

(2013) Jeffrey R. Brender et al.   CHEMICAL COMMUNICATIONS

Protein β-interfaces as a generic source of native peptide tectons

(2013) Céline Valéry et al.   CHEMICAL COMMUNICATIONS

An N-terminal pro-atrial natriuretic peptide (NT-proANP) ‘aggregation-prone’ segment involved in isolated atrial amyloidosis

(2013) Nikolaos N. Louros et al.   FEBS LETTERS

Identification of a novel ‘aggregation-prone’/‘amyloidogenic determinant’ peptide in the sequence of the highly amyloidogenic human calcitonin

(2013) Vassiliki A. Iconomidou et al.   FEBS LETTERS

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20–29) fragments

(2013) Jeffrey R. Brender et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins

(2013) Antonios C. Tsolis et al.   PLoS One

Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation

(2013) Nikolaos N. Louros et al.   PLoS One

The self-assembly, aggregation and phase transitions of food protein systems in one, two and three dimensions

(2013) Raffaele Mezzenga et al.   REPORTS ON PROGRESS IN PHYSICS

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

(2012) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F Nuclear Magnetic Resonance-Detected Kinetics of Monomer Consumption

(2012) Yuta Suzuki et al.   BIOCHEMISTRY

Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation

(2012) Michele F. M. Sciacca et al.   BIOCHEMISTRY

The interaction of amylin with other hormones in the control of eating

(2012) T. A. Lutz   DIABETES OBESITY & METABOLISM

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

(2011) Ravi Prakash Reddy Nanga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

(2011) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

An amyloidogenic determinant in n-terminal pro-brain natriuretic peptide (nt-probnp): Implications for cardiac amyloidoses

(2011) Vassiliki A. Iconomidou et al.   BIOPOLYMERS

Control of energy homeostasis by amylin

(2011) Thomas A. Lutz   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and Thermodynamics of Amylin Dimer Studied by Hamiltonian-Temperature Replica Exchange Molecular Dynamics Simulations

(2011) Rozita Laghaei et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies

(2011) X.-B. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of amylin in the control of energy homeostasis

(2010) Thomas A. Lutz   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Porcine islet amyloid polypeptide fragments are refractory to amyloid formation

(2010) Xin Zhang et al.   FEBS LETTERS

Human pro-islet amyloid polypeptide (ProIAPP1–48) forms amyloid fibrils and amyloid spherulites in vitro

(2010) Christopher Exley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mechanistic Studies of Peptide Self-Assembly: Transient α-Helices to Stable β-Sheets

(2010) Gai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

(2010) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Brainstem mechanisms of amylin-induced anorexia

(2010) Catarina Soares Potes et al.   PHYSIOLOGY & BEHAVIOR

NMR Spectroscopic Investigation of Early Events in IAPP Amyloid Fibril Formation

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Conformational polymorphism and cellular toxicity of IAPP and βAP domains

(2009) Maneesha E. Andrews et al.   JOURNAL OF STRUCTURAL BIOLOGY

Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy

(2009) Ravi Prakash Reddy Nanga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy

(2009) Ronald Soong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

(2009) S.-H. Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

(2009) A. Abedini et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Amyloidogenic determinants are usually not buried

(2009) Kimon K Frousios et al.   BMC STRUCTURAL BIOLOGY

Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19in Micelles by NMR Spectroscopy†

(2008) Ravi Prakash Reddy Nanga et al.   BIOCHEMISTRY

A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity†

(2008) Jeffrey R. Brender et al.   BIOCHEMISTRY

Das Amyloid der Langerhansschen Inseln und seine Beziehung zum Diabetes mellitus* 1

(2008) H.-M. Schneider et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

(2008) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY