Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells

(2015) Norashikin Zakaria et al.   BMC CANCER

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer

(2015) S-Q Liang et al.   Cell Death & Disease

Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatin in normal cells versus tumor cells

(2015) Yuan Zhang et al.   Scientific Reports

Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells

(2015) Philip A. Knobel et al.   NEOPLASIA

2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease

(2014) B. Besse et al.   ANNALS OF ONCOLOGY

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

(2014) Donatella Del Bufalo et al.   Molecular Cancer

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A

(2014) Anastasia Tsaalbi-Shtylik et al.   NUCLEIC ACIDS RESEARCH

Metformin Inhibits the IL-6-Induced Epithelial-Mesenchymal Transition and Lung Adenocarcinoma Growth and Metastasis

(2014) Zhongquan Zhao et al.   PLoS One

Wilms' Tumor Protein Induces an Epithelial-Mesenchymal Hybrid Differentiation State in Clear Cell Renal Cell Carcinoma

(2014) Valerie B. Sampson et al.   PLoS One

Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed

(2014) L D Weeks et al.   Cell Death & Disease

MicroRNA-34a: a potential therapeutic target in human cancer

(2014) X J Li et al.   Cell Death & Disease

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer

(2013) Masafumi Takeshita et al.   LUNG CANCER

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature

(2013) Martin P. Barr et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest

(2013) L Lundholm et al.   Cell Death & Disease

Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity

(2012) S Akunuru et al.   Cell Death & Disease

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

(2011) M Bartucci et al.   CELL DEATH AND DIFFERENTIATION

Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells

(2011) Tsung-Ying Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Comparison of pemetrexed plus cisplatin with other first-line doublets in advanced non-small cell lung cancer (NSCLC): A combined analysis of three phase 3 trials

(2011) Joseph Treat et al.   LUNG CANCER

Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways

(2011) Tsung-Ying Yang et al.   MOLECULAR CARCINOGENESIS

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

(2011) Z. P. Lin et al.   MOLECULAR PHARMACOLOGY

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

(2011) C Canino et al.   ONCOGENE

A comparative analysis of the cell biology of senescence and aging

(2009) Eun Seong Hwang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

(2009) Christophe Kunz et al.   PLOS BIOLOGY

Kinetics of H2AX phosphorylation after exposure to cisplatin

(2008) Peggy L. Olive et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase Cβ inhibitor, in non-small cell lung cancer cells

(2008) Floriana Morgillo et al.   MOLECULAR CANCER THERAPEUTICS