TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer

TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma

(2019) Zhi Tang et al.   Oncology Letters

The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms

(2018) Taishu Wang et al.   Cell Communication and Signaling

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

(2017) Rehan Ahmad et al.   Molecular Cancer

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer

(2016) Ying-Hui Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

(2016) Sixuan Qian et al.   Journal of Hematology & Oncology

Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer

(2016) Sang Hyun Kim et al.   PATHOLOGY RESEARCH AND PRACTICE

Energy disruptors: rising stars in anticancer therapy?

(2016) F Bost et al.   Oncogenesis

Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy

(2015) Bhupender Kumar et al.   BIOCHIMIE

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase

(2014) Isabelle Gerin et al.   BIOCHEMICAL JOURNAL

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

(2014) J.-M. Xie et al.   CANCER RESEARCH

Metabolic programming—knowns, unknowns and possibilities

(2014) Susan E. Ozanne   Nature Reviews Endocrinology

TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells

(2014) ELAINE YUE LING WONG et al.   Oncology Letters

Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells

(2013) Ling Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Clinical Significance of Frizzled Homolog 3 Protein in Colorectal Cancer Patients

(2013) Sze Chuen Cesar Wong et al.   PLoS One

TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

(2012) E Madan et al.   BRITISH JOURNAL OF CANCER

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells

(2011) Miguel A. Peña-Rico et al.   RADIOTHERAPY AND ONCOLOGY

p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress

(2010) Masaki Kimata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation

(2010) Vivian Wai Yan Lui et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE