TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells

(2016) Raju V. Pusapati et al.   CANCER CELL

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition

(2016) Helga Simon-Molas et al.   FEBS LETTERS

Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy

(2015) Bhupender Kumar et al.   BIOCHIMIE

MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR

(2015) Shanshan Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

(2015) Eric C. Cheung et al.   GENES & DEVELOPMENT

Multicompartment metabolism in papillary thyroid cancer

(2015) Joseph M. Curry et al.   LARYNGOSCOPE

Cancer’s Fuel Choice: New Flavors for a Picky Eater

(2015) Gina M. DeNicola et al.   MOLECULAR CELL

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism

(2015) Meiling Sun et al.   NEUROCHEMISTRY INTERNATIONAL

p53- and p73-independent activation of TIGAR expression in vivo

(2015) P Lee et al.   Cell Death & Disease

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase

(2014) Isabelle Gerin et al.   BIOCHEMICAL JOURNAL

Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties

(2014) M. Augsten et al.   CANCER RESEARCH

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

(2014) J.-M. Xie et al.   CANCER RESEARCH

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells

(2013) Ling Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

(2013) Laura Novellasdemunt et al.   BIOCHEMICAL JOURNAL

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

TIGAR Is Correlated with Maximal Standardized Uptake Value on FDG-PET and Survival in Non-Small Cell Lung Cancer

(2013) Xiang Zhou et al.   PLoS One

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα

(2013) S Sinha et al.   Cell Death & Disease

Metabolic reprogramming and two-compartment tumor metabolism

(2012) Barbara Chiavarina et al.   CELL CYCLE

Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

(2012) Federica Sotgia et al.   CELL CYCLE

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

(2012) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

(2012) Ubaldo E. Martinez-Outschoorn et al.   Cell Metabolism

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines

(2011) Shubiao Zou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells

(2011) Miguel A. Peña-Rico et al.   RADIOTHERAPY AND ONCOLOGY

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death

(2010) V W Y Lui et al.   ONCOGENE

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION