Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease

Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts

(2018) Sangmi Ock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns

(2018) Eleni Bibaki et al.   Molecular Medicine Reports

AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation

(2017) Yunjuan Nie et al.   JOURNAL OF IMMUNOLOGY

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

(2017) Elisabetta Ceni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

(2017) Marina Riggio et al.   Scientific Reports

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distinct Actions of Akt1 on Skeletal Architecture and Function

(2014) Aditi Mukherjee et al.   PLoS One

Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction

(2014) Aiping Lan et al.   PLoS One

A Chemical Epitope-Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2

(2013) Arundhati Nag et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells

(2013) Ariel E. Cariaga-Martinez et al.   CELLULAR SIGNALLING

Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy

(2013) Eric S Orman et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inhibition of CYP2E1 leads to decreased malondialdehyde–acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure

(2013) Kavitha Swaminathan et al.   LIFE SCIENCES

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

(2012) Reetta Virtakoivu et al.   MOLECULAR BIOLOGY OF THE CELL

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

(2012) Anjum Riaz et al.   PLoS One

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms

(2011) Mahnoush S. Shafiei et al.   AMERICAN JOURNAL OF PATHOLOGY

Thymosin-β4 (Tβ4) Blunts PDGF-Dependent Phosphorylation and Binding of AKT to Actin in Hepatic Stellate Cells

(2011) Karina Reyes-Gordillo et al.   AMERICAN JOURNAL OF PATHOLOGY

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

(2011) Nicole Grabinski et al.   CELLULAR SIGNALLING

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Epigenetic cell fate regulation of hepatic stellate cells

(2011) Hidekazu Tsukamoto et al.   HEPATOLOGY RESEARCH

Current status of novel antifibrotic therapies in patients with chronic liver disease

(2011) Michal Cohen-Naftaly et al.   Therapeutic Advances in Gastroenterology

Pathogenesis of alcoholic liver disease: interactions between parenchymal and non-parenchymal cells

(2010) Jessica I COHEN et al.   Journal of Digestive Diseases

Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

(2010) T. A. Yap et al.   MOLECULAR CANCER THERAPEUTICS

Akt isoforms and glucose homeostasis – the leptin connection

(2010) Nissim Hay   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines

(2009) Zheng Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

(2009) A. Di Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

(2009) Courtney-S Schaffert   WORLD JOURNAL OF GASTROENTEROLOGY

Soft Tissue Sarcoma Cells Are Highly Sensitive to AKT Blockade: A Role for p53-Independent Up-regulation of GADD45 

(2008) Q.-S. Zhu et al.   CANCER RESEARCH

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice

(2008) Kun L. Ma et al.   HEPATOLOGY