Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition

Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing

(2019) Mehdi Amirhosseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identifying Cancers Impacted by CDK8/19

(2019) Igor B. Roninson et al.   Cells

Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay

(2019) Li et al.   Cells

Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer

(2018) Anne Serrao et al.   ONCOGENE

Making Waves: New Developments in Toxicology With the Zebrafish

(2018) Katharine A Horzmann et al.   TOXICOLOGICAL SCIENCES

CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells

(2018) Akito Nakamura et al.   Oncotarget

CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases

(2018) Jiaxin Liang et al.   CANCER RESEARCH

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

(2017) Stephen Philip et al.   JOURNAL OF MEDICINAL CHEMISTRY

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

(2017) Mengqian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

(2017) Martina S.J. McDermott et al.   Oncotarget

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains

(2017) Tomasz Rzymski et al.   Oncotarget

Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening

(2016) Paul Czodrowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

(2016) Aurélie Mallinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

(2016) Michael F. T. Koehler et al.   ACS Medicinal Chemistry Letters

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

(2016) Paul A Clarke et al.   eLife

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

(2015) Aurélie Mallinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

Preclinical Toxicity of AZD7969

(2014) A. P. Hall et al.   TOXICOLOGIC PATHOLOGY

Discovery and structure–activity relationship of thienopyridine derivatives as bone anabolic agents

(2013) Keiji Saito et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

(2013) Joanna Bancerek et al.   IMMUNITY

CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

(2013) Eva Maria Putz et al.   Cell Reports

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

(2012) D. C. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues

(2009) Jun Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11

(2009) Victor J. Cee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION