Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing

Runx2, an inducer of osteoblast and chondrocyte differentiation

(2018) Toshihisa Komori   HISTOCHEMISTRY AND CELL BIOLOGY

Recent advances in osteoclast biology

(2018) Takehito Ono et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response

(2017) K. Audrey Audetat et al.   MOLECULAR AND CELLULAR BIOLOGY

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

(2017) Mengqian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK8: a new breast cancer target

(2017) John Crown   Oncotarget

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

(2017) Martina S.J. McDermott et al.   Oncotarget

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains

(2017) Tomasz Rzymski et al.   Oncotarget

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption

(2017) Kenta Watanabe et al.   FEBS Open Bio

Transcriptional regulation of bone sialoprotein gene expression by Osx

(2016) Ya Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NFATc1 regulates cell proliferation, migration, and invasion of ovarian cancer SKOV3 cells in vitro and in vivo

(2016) Long Li et al.   ONCOLOGY REPORTS

Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

(2016) Bin Huang et al.   Nature Communications

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis

(2016) Jongwon Lee et al.   Scientific Reports

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics

(2016) Zachary C. Poss et al.   Cell Reports

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

(2016) Paul A Clarke et al.   eLife

CDK8 kinase—An emerging target in targeted cancer therapy

(2015) Tomasz Rzymski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Insulin-like growth factor I enhances collagen synthesis in engineered human tendon tissue

(2015) Andreas Herchenhan et al.   GROWTH HORMONE & IGF RESEARCH

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

(2015) Megan M Weivoda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

Involvement of PU.1 in NFATc1 promoter function in osteoclast development

(2015) Kentaro Ishiyama et al.   ALLERGOLOGY INTERNATIONAL

Osteopontin mediates mineralization and not osteogenic cell developmentin vitro

(2014) Erik Holm et al.   BIOCHEMICAL JOURNAL

Emerging roles of Cdk8 in cell cycle control

(2013) Zsolt Szilagyi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Caveolae-mediated endocytosis of the glucosaminoglycan-interacting adipokine tartrate resistant acid phosphatase 5a in adipocyte progenitor lineage cells

(2013) Christina Patlaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The two faces of Cdk8, a positive/negative regulator of transcription

(2013) Josipa Nemet et al.   BIOCHIMIE

Tumor-suppressive effects of CDK8 in endometrial cancer cells

(2013) Weiting Gu et al.   CELL CYCLE

Calcifying Human Aortic Smooth Muscle Cells Express Different Bone Alkaline Phosphatase Isoforms, Including the Novel B1x Isoform

(2013) Mathias Haarhaus et al.   JOURNAL OF VASCULAR RESEARCH

Promotion of Osteoblast Differentiation in Mesenchymal Cells Through Cbl-Mediated Control of STAT5 Activity

(2013) François-Xavier Dieudonne et al.   STEM CELLS

The Role of Phosphatases in the Initiation of Skeletal Mineralization

(2012) José Luis Millán   CALCIFIED TISSUE INTERNATIONAL

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

(2012) D. C. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Jak/STAT Pathways in Osteoclast Differentiation

(2011) Young-Kyun Lee et al.   Biomolecules & Therapeutics

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

WNT/β-Catenin Signaling Is Involved in Regulation of Osteoclast Differentiation by Human Immunodeficiency Virus Protease Inhibitor Ritonavir

(2008) Rozbeh Modarresi et al.   AMERICAN JOURNAL OF PATHOLOGY

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats

(2007) K. Wermelin et al.   BONE