A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Mitochondria in non-alcoholic fatty liver disease

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Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release

(2018) Junjiang Pan et al.   CELLULAR IMMUNOLOGY

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

(2018) Ignazio Grattagliano et al.   BIOCHEMICAL PHARMACOLOGY

Fatty liver promotes fibrosis in monkeys consuming high fructose

(2017) Michael A. Cydylo et al.   Obesity

Differential Location and Distribution of Hepatic Immune Cells

(2017) Maria Freitas-Lopes et al.   Cells

Liver Mitochondrial DNA Copy Number and Deletion Levels May Contribute to Nonalcoholic Fatty Liver Disease Susceptibility

(2016) Sharareh Kamfar et al.   Hepatitis Monthly

The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health

(2016) Mary Rinella et al.   HEPATOLOGY

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

(2016) Giulio Marchesini et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences

(2016) Afshan N. Malik et al.   MITOCHONDRION

Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?

(2016) Priya Handa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance

(2016) Jessica Glen et al.   BMJ-British Medical Journal

Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance

(2016) Jessica Glen et al.   BMJ-British Medical Journal

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

(2015) Cameron G. McCarthy et al.   CARDIOVASCULAR RESEARCH

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Altered circulating mitochondrial DNA and increased inflammation in patients with diabetic retinopathy

(2015) Afshan N. Malik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Leigh disease due toSCO2mutations revealed at extended autopsy

(2015) Tamara Szymanska-Debinska et al.   JOURNAL OF CLINICAL PATHOLOGY

Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease

(2015) Carlos J. Pirola et al.   MEDICINE

Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy

(2015) Anna Czajka et al.   EBioMedicine

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias

(2011) Afshan N. Malik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of specific metabolic rates of major organs and tissues: Comparison between men and women

(2010) ZiMian Wang et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

(2010) Manal F. Abdelmalek et al.   HEPATOLOGY

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy

(2009) Afshan N. Malik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases

(2008) Christophe Rocher et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES