Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies

Are Proteinopathy and Oxidative Stress Two Sides of the Same Coin?

(2019) Nihar Mehta et al.   Cells

Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice

(2019) Lin-Bo Li et al.   Cells

Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson’s Disease

(2019) Beate Pesch et al.   Cells

Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease

(2019) Fleur McLeary et al.   Cells

Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

(2019) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Copper(II) Coordination

(2018) Tae Su Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein

(2018) Piriya Wongkongkathep et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure

(2018) Frederik Lermyte et al.   MASS SPECTROMETRY REVIEWS

Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

(2018) James Everett et al.   Nanoscale

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ferritin and neuromelanin “quantum dot” array structures in dopamine neurons of the substantia nigra pars compacta and norepinephrine neurons of the locus coeruleus

(2018) Christopher John Rourk   BIOSYSTEMS

Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

(2018) Alyssa Q. Stiving et al.   ANALYTICAL CHEMISTRY

Metals and neurodegenerative diseases. A systematic review

(2017) Calogero Edoardo Cicero et al.   ENVIRONMENTAL RESEARCH

Chemical imaging analysis of the brain with X-ray methods

(2017) Joanna F Collingwood et al.   SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY

Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material

(2017) Joanna F. Collingwood et al.   JOURNAL OF ALZHEIMERS DISEASE

NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide

(2017) Nanditha G. Nair et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Native Mass Spectrometry: What is in the Name?

(2016) Aneika C. Leney et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease

(2016) Germán Plascencia-Villa et al.   Scientific Reports

Characterization of Ca-phosphate biological materials by scanning transmission X-ray microscopy (STXM) at the Ca L 2,3 -, P L 2,3 - and C K-edges

(2015) Julie Cosmidis et al.   Acta Biomaterialia

Ion Activation Methods for Peptides and Proteins

(2015) Jennifer S. Brodbelt   ANALYTICAL CHEMISTRY

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Searching for harmony in transition-metal signaling

(2015) Christopher J Chang   Nature Chemical Biology

α-Synuclein as a ferrireductase

(2015) David R. Brown   BIOCHEMICAL SOCIETY TRANSACTIONS

Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid

(2014) James Everett et al.   INORGANIC CHEMISTRY

Mass Spectrometric Strategies to Improve the Identification of Pt(II)-Modification Sites on Peptides and Proteins

(2014) Huilin Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light

(2014) Joanna F. Collingwood et al.   Frontiers in Pharmacology

X-ray absorption spectroscopy of biological samples. A tutorial

(2012) Richard Ortega et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs

(2011) Huilin Li et al.   ANALYTICAL CHEMISTRY

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation

(2010) Heather R. Lucas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Deprotonation of the Asp1Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH

(2009) Christelle Hureau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Chemical Imaging of the Developmental Phases of Human Neuromelanin Using Synchrotron X-ray Microspectroscopy

(2008) Sylvain Bohic et al.   ANALYTICAL CHEMISTRY