Tumor-Associated Macrophages in Hematologic Malignancies: New Insights and Targeted Therapies

Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL

(2019) Helena Hohtari et al.   LEUKEMIA

AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma

(2019) John P. Leonard et al.   JOURNAL OF CLINICAL ONCOLOGY

Short regimen of rituximab plus lenalidomide in follicular lymphoma patients in need of first-line therapy

(2019) Emanuele Zucca et al.   BLOOD

CSF1R and BTK inhibitions as novel strategies to disrupt the dialog between mantle cell lymphoma and macrophages

(2019) Antonin Papin et al.   LEUKEMIA

The effects of monoclonal anti‐CD47 on RBCs, compatibility testing, and transfusion requirements in refractory acute myeloid leukemia

(2019) C.K. Brierley et al.   TRANSFUSION

Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical Application

(2019) Mulder et al.   Cancers

Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4

(2019) Jaris Valencia et al.   Cells

Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count

(2019) Yan-Li Li et al.   BMC CANCER

Association of CD204 + macrophages with poor outcomes of malignant lymphomas not in remission treated by allogeneic HCT

(2019) Akihisa Kawajiri et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

(2018) Frank Vari et al.   BLOOD

Targeting CD47 as a cancer therapeutic strategy

(2018) Alecia S. Folkes et al.   CURRENT OPINION IN ONCOLOGY

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

(2018) David K. Edwards V et al.   Oncotarget

Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma

(2018) Manh-Cuong Vo et al.   Frontiers in Immunology

Prognostic implications of tumor-infiltrating macrophages, M2 macrophages, regulatory T-cells, and indoleamine 2,3-dioxygenase-positive cells in primary diffuse large B-cell lymphoma of the central nervous system

(2018) Soo Jeong Nam et al.   OncoImmunology

The Role of Macrophage/B-Cell Interactions in the Pathophysiology of B-Cell Lymphomas

(2018) Lan V. Pham et al.   Frontiers in Oncology

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia

(2018) Shella Saint Fleur-Lominy et al.   Cell Reports

Lenalidomide in combination with R-CHOP (R2-CHOP) as first-line treatment of patients with high tumour burden follicular lymphoma: a single-arm, open-label, phase 2 study

(2018) Hervé Tilly et al.   Lancet Haematology

CSF1R inhibitors exhibit anti-tumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

(2018) David K. Edwards et al.   BLOOD

Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530

(2018) Silvia L. Locatelli et al.   CLINICAL CANCER RESEARCH

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

(2018) Ann Hanna et al.   OncoImmunology

Tumor-associated macrophages: implications in cancer immunotherapy

(2017) Amy J Petty et al.   Immunotherapy

Therapeutic effects of CSF1R-blocking antibodies in multiple myeloma

(2017) Q Wang et al.   LEUKEMIA

Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters

(2017) Gabor J. Szebeni et al.   MEDIATORS OF INFLAMMATION

IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell Lung Cancer

(2017) Xin Wang et al.   RADIATION RESEARCH

Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

(2017) Xiao Yang et al.   OncoImmunology

T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells

(2016) I. Azzaoui et al.   BLOOD

Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma

(2016) Baoping Guo et al.   BMC Medicine

Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia

(2016) A. Polk et al.   CLINICAL CANCER RESEARCH

Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

(2016) Y. S. Al-Matary et al.   HAEMATOLOGICA

Reprogramming Nurse-like Cells with Interferon γ to Interrupt Chronic Lymphocytic Leukemia Cell Survival

(2016) Shalini Gautam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cells and macrophages pursue a common path toward the development and progression of chronic lymphocytic leukemia

(2016) G Galletti et al.   LEUKEMIA

Lymphocyte-to-monocyte ratio is associated with prognosis of diffuse large B-cell lymphoma: correlation with CD163 positive M2 type tumor-associated macrophages, not PD-1 positive tumor-infiltrating lymphocytes

(2016) Jingxuan Wang et al.   Oncotarget

Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression

(2016) Giovanni Galletti et al.   Cell Reports

Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

(2016) Y. S. Al-Matary et al.   HAEMATOLOGICA

M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma

(2016) Long Shen et al.   Scientific Reports

Organ-Specific Microenvironment Modifies Diverse Functional and Phenotypic Characteristics of Leukemia-Associated Macrophages in Mouse T Cell Acute Lymphoblastic Leukemia

(2015) Sha-Yan Chen et al.   JOURNAL OF IMMUNOLOGY

Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma

(2015) S Panchabhai et al.   LEUKEMIA

Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo

(2015) B S Hanna et al.   LEUKEMIA

Nurse like cells: chronic lymphocytic leukemia associated macrophages

(2015) Frédéric Boissard et al.   LEUKEMIA & LYMPHOMA

The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma

(2015) Morten N. Andersen et al.   LEUKEMIA RESEARCH

A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells

(2015) Emily C Piccione et al.   mAbs

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Role of tumor-associated macrophages in hematological malignancies

(2015) Yoshihiro Komohara et al.   PATHOLOGY INTERNATIONAL

IL-10 induces the development of immunosuppressive CD14+HLA-DRlow/− monocytes in B-cell non-Hodgkin lymphoma

(2015) B Xiu et al.   Blood Cancer Journal

CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma

(2015) Ana M. Martín-Moreno et al.   PLoS One

Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia

(2014) L. Jia et al.   BLOOD

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

(2014) Valentina Audrito et al.   BLOOD

Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages

(2014) P. Giannoni et al.   HAEMATOLOGICA

High density of CD68+/CD163+ tumour-associated macrophages (M2-TAM) at diagnosis is significantly correlated to unfavorable prognostic factors and to poor clinical outcomes in patients with diffuse large B-cell lymphoma

(2014) Francesco Marchesi et al.   HEMATOLOGICAL ONCOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

(2014) Wenjuan Xuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Tumor-associated macrophages as a prognostic parameter in multiple myeloma

(2013) Elif Suyanı et al.   ANNALS OF HEMATOLOGY

Lenalidomide reduces survival of chronic lymphocytic leukemia cells in primary cocultures by altering the myeloid microenvironment

(2013) A. Schulz et al.   BLOOD

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Clinical significance of CD163+tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

Macrophages in multiple myeloma: emerging concepts and therapeutic implications

(2013) Fotis Asimakopoulos et al.   LEUKEMIA & LYMPHOMA

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes

(2012) F. Guilloton et al.   BLOOD

Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial

(2012) K. L. Tan et al.   BLOOD

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells

(2012) Jaehyup Kim et al.   BRITISH JOURNAL OF HAEMATOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

(2012) Nina Linde et al.   JOURNAL OF PATHOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

(2012) D Kim et al.   LEUKEMIA

Monocytes and T cells cooperate to favor normal and follicular lymphoma B-cell growth: role of IL-15 and CD40L signaling

(2011) G Epron et al.   LEUKEMIA

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Immunosuppressive CD14+HLA-DRlow/- monocytes in B-cell non-Hodgkin lymphoma

(2010) Y. Lin et al.   BLOOD

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment

(2010) A. J. Clear et al.   BLOOD

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways

(2010) Klaus Podar et al.   CELL CYCLE

Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations

(2010) Shlomit Kfir-Erenfeld et al.   LEUKEMIA & LYMPHOMA

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis

(2009) Y. Zheng et al.   BLOOD

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

(2008) J. A. Burger et al.   BLOOD

Lenalidomide for the Treatment of B-Cell Malignancies

(2008) Asher A. Chanan-Khan et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Numbers of Tumor-Associated Macrophages Have an Adverse Prognostic Value That Can Be Circumvented by Rituximab in Patients With Follicular Lymphoma Enrolled Onto the GELA-GOELAMS FL-2000 Trial

(2007) Danielle Canioni et al.   JOURNAL OF CLINICAL ONCOLOGY