The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

Glutamine Addiction In Gliomas

(2017) Javier Márquez et al.   NEUROCHEMICAL RESEARCH

Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD

(2016) Yuwen Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

(2016) Weina Zhao et al.   CANCER RESEARCH

Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties

(2016) A N Paranjape et al.   ONCOGENE

Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth

(2016) S J Werden et al.   ONCOGENE

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

(2016) Su Yeon Lee et al.   Oncotarget

α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue

(2016) Lu Gan et al.   Scientific Reports

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

(2016) Cen Zhang et al.   eLife

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy

(2015) Emilie Obre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Downregulation ofGLS2in glioblastoma cells is related to DNA hypermethylation but not to the p53 status

(2015) Monika Szeliga et al.   MOLECULAR CARCINOGENESIS

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

EMT-induced metabolite signature identifies poor clinical outcome

(2015) Salil Kumar Bhowmik et al.   Oncotarget

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

(2013) Jianbin Zhang et al.   BMC CANCER

FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer

(2013) B. G. Hollier et al.   CANCER RESEARCH

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

(2013) Tania Velletri et al.   CELL CYCLE

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells

(2013) Mercedes Martín-Rufián et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

(2013) Y. Yao et al.   Science Signaling

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

(2013) Monika Szeliga et al.   TUMOR BIOLOGY

A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity

(2012) Frances L. Shaw et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Twist2 contributes to breast cancer progression by promoting an epithelial–mesenchymal transition and cancer stem-like cell self-renewal

(2011) X Fang et al.   ONCOGENE

Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone

(2011) Joakim Håkansson et al.   Diabetology & Metabolic Syndrome

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes

(2009) Qin Hao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Glutamine homeostasis and mitochondrial dynamics

(2009) José M. Matés et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells

(2008) Monika Szeliga et al.   GLIA

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

(2008) Y. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of the scaffolding PDZ protein glutaminase-interacting protein in mammalian brain

(2007) Lucía Olalla et al.   JOURNAL OF NEUROSCIENCE RESEARCH