Downregulation ofGLS2in glioblastoma cells is related to DNA hypermethylation but not to the p53 status

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype

(2015) Monika Szeliga et al.   NEUROCHEMISTRY INTERNATIONAL

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

(2015) Juan Liu et al.   Oncotarget

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

(2015) Yue-Zhi Lee et al.   Oncotarget

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation

(2013) Lisha Xiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

(2013) Jianbin Zhang et al.   BMC CANCER

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

(2013) Tania Velletri et al.   CELL CYCLE

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation

(2013) Shuo Qie et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells

(2013) Mercedes Martín-Rufián et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

(2012) Krupa Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

(2012) Monika Szeliga et al.   JOURNAL OF NEUROCHEMISTRY

Mammalian glutaminase isozymes in brain

(2012) Javier Márquez et al.   METABOLIC BRAIN DISEASE

Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism

(2012) Mercedes Martín-Rufián et al.   PLoS One

Analysis of Intron Sequence Features Associated with Transcriptional Regulation in Human Genes

(2012) Huimin Li et al.   PLoS One

Genetic profile of astrocytic and oligodendroglial gliomas

(2011) Hiroko Ohgaki et al.   Brain Tumor Pathology

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

The DNA methylome of glioblastoma multiforme

(2010) Ramon Martinez et al.   NEUROBIOLOGY OF DISEASE

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma

(2009) N.P. Anselmo et al.   GENETICS AND MOLECULAR RESEARCH

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells

(2008) Monika Szeliga et al.   GLIA