Article
Medicine, General & Internal
Jesmond Dalli, Douglas Kitch, Meagan P. Brien, Peter W. Hunt, Nicholas Funderburg, Daniela Moisi, Amita Gupta, Todd T. Brown, Phyllis C. Tien, Judith A. Aberg, Rupak Shivakoti
Summary: People with HIV have an increased risk of cardiovascular disease compared to HIV-negative individuals. In this study, we found that HIV-positive individuals have lower levels of pro-inflammatory lipid mediators and higher levels of pro-resolving lipid mediators compared to HIV-negative individuals. We also observed that aspirin treatment in HIV-positive individuals reduced the levels of pro-inflammatory lipid mediators and upregulated certain pro-resolving lipid mediators.
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
Review
Immunology
Christa Decker, Sudeshna Sadhu, Gabrielle Fredman
Summary: The resolution of inflammation is a tissue protective program governed by factors such as specialized pro-resolving mediators. Phagocytes like neutrophils and macrophages play key roles in this process by removing debris, microbes, and dead cells. Enhancing factors and mechanisms associated with phagocytosis and efferocytosis are critical for understanding and treating prevalent human diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cassia de Faveri, Paula M. Poeta Fermino, Anna P. Piovezan, Lia K. Volpato
Summary: The pathogenesis of endometriosis is still controversial, with the inflammatory immune response playing a critical role. Pro-resolving mediators (PRMs) in endometriosis are not well understood, but research shows their potential in inhibiting disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wheeler Torres, Jose Luis Perez, Maria P. Diaz, Luis D'Marco, Ana Checa-Ros, Ruben Carrasquero, Lisse Angarita, Yosselin Gomez, Maricarmen Chacin, Paola Ramirez, Nelson Villasmil, Samuel Duran-Aguero, Climaco Cano, Valmore Bermudez
Summary: Cancer is a major global health issue characterized by cell mutation, proliferation, invasion, and metastasis. The increasing incidence of cancer highlights the need for new approaches to understand the molecular changes involved in its development, including chronic inflammation. Specialized pro-resolving mediators (SPMs), bioactive lipids derived from polyunsaturated fatty acids (PUFAs), have shown potential as novel anti-inflammatory molecules that could improve anti-tumor immunity. This review aims to explore the effects of SPMs on carcinogenesis and their therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Giordani, Giulia Matacchione, Angelica Giuliani, Debora Valli, Emanuele Salvatore Scarpa, Antonella Antonelli, Jacopo Sabbatinelli, Gilberta Giacchetti, Sofia Sabatelli, Fabiola Olivieri, Maria Rita Rippo
Summary: During aging, bone marrow mesenchymal stromal cells (MSCs) undergo cellular senescence and acquire a pro-inflammatory secretory phenotype, leading to osteoporosis. In this study, the combination of orthosilicic acid (OA) and vitamin K2 (VK2), along with three anti-inflammatory compounds (curcumin, polydatin, and quercetin) showed potential in promoting MSC osteogenesis and inhibiting their pro-inflammatory phenotype. These natural compounds could be used as a supplement to prevent or control age-related osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Omayra Martin-Rodriguez, Thierry Gauthier, Francis Bonnefoy, Melanie Couturier, Anna Daoui, Cecile Chague, Severine Valmary-Degano, Claire Gay, Philippe Saas, Sylvain Perruche
Summary: The study focuses on evaluating the efficacy of pro-resolving factors produced by macrophages after efferocytosis in treating IBD. Reintroduction of these factors was shown to reduce inflammation in colitis models and promote tissue repair, with TGF-beta, IGF-I and VEGF identified as key factors. The administration of these pro-resolving factors released by efferocytic macrophages represents an innovative treatment approach for IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matti Hoch, Jannik Rauthe, Konstantin Cesnulevicius, Myron Schultz, David Lescheid, Olaf Wolkenhauer, Valerio Chiurchiu, Shailendra Gupta
Summary: Lipid mediators play important roles in regulating inflammatory responses, and their biosynthetic pathways are targeted by common anti-inflammatory drugs. Transitioning from pro-inflammatory lipid mediators (PIMs) to specialized pro-resolving mediators (SPMs) is crucial for resolving acute inflammation and preventing chronic inflammation. This study used the Atlas of Inflammation Resolution to construct a gene regulatory network associated with SPM and PIM biosynthesis. By analyzing single-cell sequencing data and using machine learning approaches, the researchers identified cell type-specific gene regulatory networks and demonstrated the impact of immune cell activation on PIM and SPM profiles. This research provides insights into the gene regulation of lipid mediators in immune responses and highlights the contribution of specific cell types in their biosynthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Marta Tiberi, Valerio Chiurchiu
Summary: Astrocytes and oligodendrocytes play crucial roles in the central nervous system and are involved in immune regulation and inflammation processes. The superfamily of specialized pro-resolving lipid mediators (SPMs) play a key role in resolving inflammation and controlling neuroinflammation and neurodegeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Valeria Policastro, Dario Righelli, Lucilla Rava, Pamela Vernocchi, Marzia Bianchi, Cristina Vallone, Fabrizio Signore, Melania Manco
Summary: In this study, the association between dietary fatty acids and pro- and anti-inflammatory molecules in pregnant women was investigated. Several associations were found, including those between adiponectin and specific fatty acids, endotoxin and specific fatty acids, MCP-1 and a specific fatty acid, and ICAM-1 and a specific fatty acid. Additionally, cytokines such as leptin were associated with maternal body weight, smoking habits, and gestational diabetes.
Review
Immunology
Wenji Zhang, Hui Lin, Mingmin Zou, Qinghua Yuan, Zhenrui Huang, Xiaoying Pan, Wenjuan Zhang
Summary: Nicotine, as an anti-inflammatory alkaloid, has dual roles in treating diseases. It predominantly exhibits anti-inflammatory effects, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia, but may promote and aggravate certain diseases such as periodontitis and gingivitis in oral inflammation. The molecular mechanism of nicotine in these inflammatory diseases involves regulating immune cells, immune factors, and the vagus and acetylcholinergic anti-inflammatory pathways, offering potential value for remedying acute and chronic inflammation in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Zhijuan Miao, Marianne Schultzberg, Xiuzhe Wang, Yuwu Zhao
Summary: Polyunsaturated fatty acids (PUFAs) have shown potential benefits in the prevention and treatment of ischemic stroke, with specialized pro-resolving mediators (SPMs) as promising new anti-stroke therapy.
CLINICAL NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Alessandro Leuti, Marina Fava, Niccolo Pellegrini, Mauro Maccarrone
Summary: Inflammation and neuroinflammation play critical roles in generating neuropathic pain in chronic diseases, with specialized pro-resolving mediators emerging as crucial in regulating the inflammatory cascade and onset of chronic inflammation and pain. Accumulating evidence suggests a synergy between these mediators and other signaling pathways, implying a more intricate relationship between inflammation and pain perception than initially anticipated.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Maria G. Balta, Evangelos Papathanasiou, Panagiotis F. Christopoulos
Summary: This review highlights the importance of specialized pro-resolving mediators (SPMs) in the treatment of COVID-19, emphasizing their role in regulating macrophages and promoting resolution of inflammation. It also discusses the molecular events linking lipid mediators with COVID-19 severity and the clinical potentials of SPMs in COVID-19 immunotherapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alasdair G. Kay, Kane Treadwell, Paul Roach, Rebecca Morgan, Rhys Lodge, Mairead Hyland, Anna M. Piccinini, Nicholas R. Forsyth, Oksana Kehoe
Summary: This study evaluated the therapeutic potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) in an antigen-induced model of arthritis. The results showed that these EVs reduced knee-joint swelling, improved histopathological outcomes, and regulated T cell polarization. Among the different conditions tested, EVs cultured under normoxic conditions demonstrated the optimal therapeutic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ha Thi Thu Do, Chang Hoon Lee, Jungsook Cho
Review
Oncology
Nguyen Minh Tuan, Chang Hoon Lee
Article
Biochemistry & Molecular Biology
Seung Bae Rho, Seung-Hoon Lee, Hyun-Jung Byun, Boh-Ram Kim, Chang Hoon Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Cell Biology
Nguyen Thi Ha, Chang Hoon Lee
Review
Chemistry, Medicinal
Chang Hoon Lee
Summary: Viral infections, including SARS-CoV-2, can cause systemic inflammation leading to severe illness and mortality. Special pro-resolving lipids mediators show promise as potential therapeutic options for viral-triggered inflammation, with ongoing research on their effects in SARS-CoV-2 infection.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Oncology
Phuong Anh Do, Chang Hoon Lee
Summary: CDK5 is a serine/threonine type kinase primarily found in nerves that has been recently recognized for its importance in cancer. Its inhibitors have the potential to be used as treatments for refractory cancer.
Review
Biochemistry & Molecular Biology
Enkhmend Enkhtaivan, Chang Hoon Lee
Summary: Neurotransmitters such as histamine and serotonin play a significant role in melanogenesis, affecting different stages of melanin production. Research has shown that neurotransmitters can increase melanin production, indicating a need for further study on the role of neurotransmitters in skin pigment disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Chang Hoon Lee, Heesoon Lee, Jungsook Cho
Summary: The novel derivative YRL1091 induces paraptosis, characterized by cytoplasmic vacuolation and specific protein regulation, in breast cancer cells. It activates signaling pathways and causes reactive oxygen species generation and endoplasmic reticulum stress, leading to cell death.
Article
Chemistry, Medicinal
Sung Ho Lim, Ho Seon Lee, Chang Hoon Lee, Chang-Ik Choi
Summary: Garcinia indica, also known as kokum, is a tropical evergreen tree used in culinary and traditional medicine. Various phytochemicals have been isolated from G. indica, showing pharmacological activities such as antioxidant and anti-inflammatory effects, indicating its potential as a promising therapeutic agent.
Article
Chemistry, Medicinal
Kyeong Lee, Hossam Nada, Hyun Jung Byun, Chang Hoon Lee, Ahmed Elkamhawy
Summary: A hybrid approach of structure-based design and virtual combinatorial library was used to generate 34 potential selective EphB3 inhibitors, with compound 4c showing the highest binding free energy in molecular docking studies. Biological evaluation confirmed its potency as an EphB3 inhibitor. Further screening against a kinase panel demonstrated selective activity against the EphB3 isoform, with insights provided by dose-dependent assays and molecular docking studies.
Review
Chemistry, Medicinal
Hieu Huy Phung, Chang Hoon Lee
Summary: This review summarized the histopathology and pathogenesis of nonalcoholic steatohepatitis (NASH), examined the applicability of mouse models in NASH research, and discussed the development of effective inhibitors based on selected cases. The understanding of NASH pathogenesis and the utilization of appropriate animal models are crucial for developing successful anti-NASH agents.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Ahmed Elkamhawy, Young Hee Choi, Chang Hoon Lee, Kyeong Lee, Jungsook Cho
Summary: The study evaluated the antitumor effects of a series of CA inhibitors on various cancer cell lines, identifying two compounds with potent anticancer activity against breast cancer cells MCF-7 and SK-BR-3, especially in combination with DOX, demonstrating synergistic cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lu Yu, Ho Lee, Seung Bae Rho, Mi Kyung Park, Chang Hoon Lee
Summary: This article introduces the research progress of ethacrynic acid (ECA) and its derivatives as potential anticancer agents. Despite limitations and side effects in its clinical application, ECA has been shown to impact multiple hallmark processes of cancer through various mechanisms. Additionally, the trend of synthesis research to improve the bioavailability of ECA is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won, Kyeong Lee
Summary: In this study, a series of novel dual MDH1/2 inhibitors were designed and synthesized, and their structure-activity relationship was investigated. Among the tested compounds, compound 50 containing a piperidine ring showed improved growth inhibition of A549 and H460 lung cancer cell lines compared to LW1497. Compound 50 reduced the total ATP content in A549 cells in a dose-dependent manner and suppressed the accumulation of HIF-1a and expression of HIF-1a target genes such as GLUT1 and PDK1. Furthermore, compound 50 inhibited HIF-1a-regulated CD73 expression under hypoxia in A549 lung cancer cells. These results suggest that compound 50 may be a potential candidate for the development of next-generation dual MDH1/2 inhibitors to target lung cancer.
Review
Biochemistry & Molecular Biology
Thi Ha Nguyen, Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Taesik You, Mi Kyung Park, Chang Hoon Lee
Summary: This review discusses the molecular mechanisms of autophagy and mitophagy in hepatocellular carcinoma (HCC) and highlights the dual role of autophagy in tumor initiation and progression. Additionally, a detailed analysis of autophagy- and mitophagy-related molecules reveals their specific functions during tumorigenesis and the progression of HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
