Article
Pharmacology & Pharmacy
Efstratios Katsianos, Evangelos Oikonomou, Konstantinos Kalogeras, Alexandra Manousaki, Charalambos Kalantzis, Panteleimon Pantelidis, Michael-Andrew Vavuranakis, Konstantina Aggeli, Gerasimos Siasos, Costas Tsioufis, Manolis Vavuranakis
Summary: This retrospective cohort study investigates the impact of baseline foramen ovale (PFO) anatomy on the severity of the postclosure shunt. The study found that patients with high-risk PFO anatomy had a higher degree of residual right-to-left shunt compared to those with non-high-risk anatomy. Prolonged antiplatelet therapy may benefit patients with high-risk anatomical features.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Clinical Neurology
Xianwen Wang, Xiangwei Liu, Lulu Zheng, Yubo Liu, Zhengyan Guan, Jingyi Dai, Xiaobin Chen
Summary: This study aimed to investigate whether there is a reduction in the recurrence rate of unexplained syncope after PFO closure, and found that the frequency of syncope episodes, hypertension, and residual RLS post closure were associated with the number of recurrences.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Bosi Dong, Ying Lu, Siyu He, Baichuan Li, Yajiao Li, Qi Lai, Wanling Li, Shuming Ji, Yucheng Chen, Lunzhi Dai, Lei Chen
Summary: Epley maneuver combined with canaloith repositioning procedure is an effective treatment for vertigo and dizziness, which can significantly improve the quality of life and treatment outcomes of patients and reduce the risk of canalith recurrence.
Article
Neurosciences
Zhen-Ni Guo, Yang Qu, Yongsheng Gao, Yingqi Xing, Hongyin Ma, Jia Liu, Yu-Zhu Guo, Junlei Chang, Peng Zhang, Hang Jin, Xin Sun, Ke Han, Han-Hwa Hu, Qianyan He, David Martin Simpson, Yi Yang
Summary: This study aimed to investigate the changes in dynamic cerebral autoregulation (dCA), stroke-related blood biomarkers, and autonomic regulation after patent foramen ovale (PFO) closure in severe migraine patients. The results showed that the dCA function of PFO migraineurs was significantly lower than that of non-PFO migraineurs and controls at baseline, but rapidly improved after PFO closure and remained stable at 1-month follow-up. Arterial blood platelet-derived growth factor-BB (PDGF-BB) levels were elevated in PFO migraineurs and significantly reduced after closure. There were no differences in autonomic regulation among the three groups.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pediatrics
Zeyu Mi, Gang He, Chao Li, Deyu Yang, Xue Liu, Libo Zhao, Hongli Gao, Xing Li, Xiaogang Zhou
Summary: This retrospective analysis evaluates the efficacy of transesophageal ultrasound-guided PFO closure in treating migraine in adolescents and compares the outcomes between migraine with and without aura. The results show that PFO closure can effectively alleviate migraine symptoms in adolescents with concomitant PFO, and the therapeutic efficacy is particularly pronounced for migraine with aura. Furthermore, residual shunt has no significant impact on the improvement of migraine symptoms.
FRONTIERS IN PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Myeong-Hoon Ji, Youl-Hun Seoung
Summary: This study presents an alternative method for assessing right-to-left shunt (RLS) associated with patent foramen ovale (PFO) using contrast transcranial color-coded Doppler (C-TCCD). The findings highlight the importance of C-TCCD screening in detecting RLS associated with PFO, especially in cryptogenic stroke patients.
Article
Clinical Neurology
Jean-Louis Mas, Benoit Guillon, Anais Charles-Nelson, Valerie Domigo, Laurent Derex, Evelyne Massardier, Caroline Arquizan, Fabrice Vuillier, Serge Timsit, Yannick Bejot, Olivier Detante, Denis Sablot, Celine Guidoux, Igor Sibon, Nelly Dequatre-Ponchelle, Emmanuel Touze, Sandrine Canaple, Sonia Alamowitch, Pierre Aubry, Emmanuel Teiger, Genevieve Derumeaux, Gilles Chatellier
Summary: In young and middle-aged adults with PFO-related cryptogenic stroke and migraine, PFO closure plus antiplatelet therapy did not reduce the mean annual number of migraine attacks compared to antiplatelet therapy alone, in migraine patients both with and without aura.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anni Chen, Jianbo Zhu, Lei Zhu, Yunyi Tang, Yun Li, Qi Zhang, Yeping Zhao, Caiye Ma, Xiatian Liu
Summary: This study aimed to clarify the incidence and characteristics of pulmonary right-to-left shunt (P-RLS) using contrast transesophageal echocardiography (c-TEE) and contrast transthoracic echocardiography (c-TTE). The results showed that the incidence of P-RLS was significantly higher under c-TEE than under c-TTE in patients with and without patent foramen ovale (PFO). The study emphasizes the importance of differentiating P-RLS and PFO-RLS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Farhan Khan, Paul Fiorilli, Steven R. Messe, Scott E. Kasner, Laith A. Derbas, Clifford J. Kavinsky, Christopher G. Favilla
Summary: There are key differences between neurologists and cardiologists in their approach to PFO closure after stroke, particularly in interpreting stroke etiology and considering closure beyond the scope of prior trials; collaboration between cardiologists and neurologists is crucial.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Pristipino, Peter Germonpre, Danilo Toni, Horst Sievert, Bernhard Meier, Fabrizio D'Ascenzo, Sergio Berti, Eustaquio Maria Onorato, Francesco Bedogni, Jean-Louis Mas, Paolo Scacciatella, David Hildick-Smith, Fiorenzo Gaita, Paul A. Kyrle, John Thomson, Genevieve Derumeaux, Dirk Sibbing, Massimo Chessa, Marius Hornung, Jose Zamorano, Dariusz Dudek, Fabrizio O'Ascenzo, Pierluigi Omede, Flavia Ballocca, Umberto Barbero, Francesca Giordana, Sebastiano Gili, Mario Iannaccone, Teiji Akagi, Gianpaolo Anzola, John Carroll, Bharat Dalvi, Claudio De Angelis, Ge Junbo, Scott E. Kasner, Ina Michel-Behnke, Giuseppe Musumeci, Lars Sondergaard, Giuseppe Tarantini, Giuseppe G. L. Biondi-Zoccai, Davide Capodanno, Marco Valgimigli, Robert Byrne, Vijay Kunadian
Summary: This interdisciplinary position paper, recognizing the low or very low certainty of existing evidence, provides the first approach to several PFO-related clinical scenarios beyond left circulation thromboembolism and strongly stresses the need for fresh high-quality evidence on these topics. Despite being based on limited and observational or low-certainty randomized data, a number of position statements were made to frame PFO management in different clinical settings, along with suggestions for new research avenues.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Pristipino, Peter Germonpre, Danilo Toni, Horst Sievert, Bernhard Meier, Fabrizio DAscenzo, Sergio Berti, Eustaquio Maria Onorato, Francesco Bedogni, Jean-Louis Mas, Paolo Scacciatella, David Hildick-Smith, Fiorenzo Gaita, Paul A. Kyrle, John Thomson, Genevieve Derumeaux, Dirk Sibbing, Massimo Chessa, Marius Hornung, Jose Zamorano, Dariusz Dudek, Fabrizio D'Ascenzo, Pierluigi Omede, Flavia Ballocca, Umberto Barbero, Francesca Giordana, Sebastiano Gili, Mario Iannaccone, Teiji Akagi, Gianpaolo Anzola, John Carroll, Bharat Dalvi, Claudio De Angelis, Ge Junbo, Scott E. Kasner, Ina Michel-Behnke, Giuseppe Musumeci, Lars Sondergaard, Giuseppe Tarantini, Giuseppe G. L. Biondi-Zoccai, Davide Capodanno, Marco Valgimigli, Robert Byrne, Vijay Kunadian
Summary: This interdisciplinary position paper, involving eight European scientific societies, provides decision-making rationale for various PFO-related clinical scenarios beyond left circulation thromboembolism, despite the low certainty of existing evidence. Fresh high-quality evidence is strongly emphasized for these topics.
EUROPEAN HEART JOURNAL
(2021)
Article
Acoustics
Ying Zhu, Jun Zhang, Bo Huang, Yani Liu, Youbin Deng, Yahui Weng, Ruiying Sun
Summary: The morphologic characteristics of PFO were found to impact the severity of right-to-left shunt in patients with PFO and cryptogenic stroke. Severe RLS or constant RLS groups had more territorial ischemic lesions, indicating different cerebral ischemia lesion patterns in these patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mohamad Alkhouli, Holly K. Van Houten, Xiaoxi Yao, David R. Holmes
Summary: In contemporary US practice, transcatheter closure of patent foramen ovale (PFO) is not associated with lower rates of recurrent ischemic stroke or systemic embolization compared with medical therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Chayakrit Krittanawong, Bing Yue, Muzamil Khawaja, Anirudh Kumar, Hafeez Ul Hassan, Zhen Wang, Sana Hanif, Umair Khalid, Ali E. Denktas, Clifford J. Kavinsky, John J. Volpi, Hani Jneid
Summary: Current estimates suggest that a patent foramen ovale (PFO) is present in up to 25% of the general population and is a potential risk factor for embolic, ischemic stroke. Complications of PFO closure include bleeding, surgical intervention, pulmonary emboli, device malpositioning, arrhythmias, and atrioventricular block. The rates of PFO closure complications at a national level in the United States are still unknown.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Giuseppe Verolino, Dario Calderone, Mara Gavazzoni, Davide Sala, Paolo Sganzerla
Summary: The study investigated the performance of the GORE Septal Occluder in PFO closure procedures and found a high closure rate across different anatomies. The GSO system demonstrated effective closure for PFO patients with varying widths and tunnel lengths.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Peng Zhang, Xin Sun, Hang Jin, Fu-Liang Zhang, Zhen-Ni Guo, Yi Yang
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Psychiatry
Shan Lv, Zan Wang, Xin Sun, Hang Jin, Jia Liu, Fang Deng, Yudan Lv, Meiyan Jia, Zhen-Ni Guo, Yi Yang
FRONTIERS IN PSYCHIATRY
(2020)
Article
Clinical Neurology
Yao-De He, Zhen-Ni Guo, Chen Qin, Hang Jin, Peng Zhang, Reziya Abuduxukuer, Yi Yang
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Yao Yu, Fu-Liang Zhang, Zhen-Ni Guo, Yi Yang
Article
Clinical Neurology
Y. Yu, F. -L. Zhang, X. -L. Yan, P. Zhang, Z. -N. Guo, Y. Yang
Summary: This study found that the visceral adiposity index (VAI) was associated with carotid plaque and cervical artery stenosis (CAS) in the general population over 40 years old in northeast China, but showed little significance with increased intima-media thickness (IMT) in cervical arteries.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Yingying Sun, Zhen-Ni Guo, Xiuli Yan, Meiqi Wang, Peng Zhang, Haiqiang Qin, Yan Wang, Hongjing Zhu, Yi Yang
Summary: The meta-analysis evaluated the safety and efficacy of tirofiban combined with EVT for treating AIS, showing that this treatment did not increase the risks of symptomatic intracranial hemorrhage or mortality, but was associated with significantly improved functional outcomes in AIS patients.
Article
Neurosciences
Chao Li, Yan Wang, Xiu-Li Yan, Zhen-Ni Guo, Yi Yang
Summary: Vascular dementia is the second leading cause of dementia after Alzheimer's disease, mainly caused by decreased cerebral blood flow. Research shows that reduced CBF leads to changes in the neurovascular unit, playing a key role in the pathogenesis of VD. Therefore, remote ischemic preconditioning may be a promising approach for VD prevention and treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Geriatrics & Gerontology
Zhong-Xiu Wang, Chao Wang, Peng Zhang, Yang Qu, Zhen-Ni Guo, Yi Yang
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Zhen-Ni Guo, Yang Qu, Hailili Reziya, Jia Liu, Xiu-Li Van, Peng Zhang, Pan-Deng Zhang, Shuang Qi, Yi Yang
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Review
Endocrinology & Metabolism
Jie Liu, Xin Sun, Fu-Liang Zhang, Hang Jin, Xiu-Li Yan, Shuo Huang, Zhen-Ni Guo, Yi Yang
Summary: Type 2 diabetes (T2D) is a major global public health disease characterized by insulin resistance, insufficient pancreatic beta-cell mass, and chronic inflammation. Recent research has highlighted the critical role of extracellular vesicles (EVs) in the pathogenesis of T2D, which can be utilized for diagnosis and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Yao Yu, Fu-Liang Zhang, Yin-Meng Qu, Peng Zhang, Hong-Wei Zhou, Yun Luo, Yan Wang, Jia Liu, Hai-Qiang Qin, Zhen-Ni Guo, Yi Yang
Summary: This study investigated the relationship between calcification in the main cerebral vessels and hemorrhagic transformation following thrombolysis treatment. The results showed that calcification volume on the lesion side was associated with hemorrhagic transformation, and an increased number of calcified vessels correlated with a higher risk of poor prognosis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Review
Cell Biology
Jia-Xin Ren, Chao Li, Xiu-Li Yan, Yang Qu, Yi Yang, Zhen-Ni Guo
Summary: Oxidative stress and ferroptosis/oxytosis are key factors in ischemic stroke, sharing common molecular pathways. Understanding the interaction between oxidative stress and ferroptosis/oxytosis is crucial for a better comprehension and treatment of ischemic stroke.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Endocrinology & Metabolism
Fu-Liang Zhang, Jia-Xin Ren, Peng Zhang, Hang Jin, Yang Qu, Yao Yu, Zhen-Ni Guo, Yi Yang
Summary: The study found that waist circumference and waist-to-height ratio were more closely related to diabetes among participants aged 40 and above, especially in females.
JOURNAL OF DIABETES RESEARCH
(2021)
Review
Immunology
Dianhui Zhang, Jiaxin Ren, Yun Luo, Qianyan He, Ruoyu Zhao, Junlei Chang, Yi Yang, Zhen-Ni Guo
Summary: This review discusses the role of T cells in ischemic stroke, including mediators of recruitment, temporal course of infiltration, and mechanisms behind deleterious and beneficial effects. Research indicates conflicting roles of T cells in post-stroke inflammation and as potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu, Zhen-Ni Guo
Summary: Ischemic stroke, caused by sudden reduction in cerebral blood flow, is a major cause of severe disability and death globally. The use of tissue plasminogen activator (tPA) for thrombolysis treatment has limitations, but nanotechnology-based strategies have shown promise in improving thrombolytic efficacy and targeted delivery of thrombolytic agents.