Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to improve its pharmacokinetic profile and anticancer efficacy

Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors

(2019) Parikshit Banerjee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Repurposing Disulfiram as an Anti-Cancer Agent: Updated Review on Literature and Patents

(2019) Elmira Ekincia et al.   Recent Patents on Anti-Cancer Drug Discovery

Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate

(2019) Si-yuan You et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Highly Stable, Coordinated Polymeric Nanoparticles Loading Copper(II) Diethyldithiocarbamate for Combinational Chemo/Chemodynamic Therapy of Cancer

(2019) Xinyu Peng et al.   BIOMACROMOLECULES

Nanocarrier-mediated co-delivery systems for lung cancer therapy: recent developments and prospects

(2019) Muhammad Asim Farooq et al.   Environmental Chemistry Letters

Repurposing disulfiram for cancer therapy via targeted nanotechnology through enhanced tumor mass penetration and disassembly

(2018) Huacheng He et al.   Acta Biomaterialia

Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin

(2018) Chun Y. Wong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Disulfiram-loaded mixed nanoparticles with high drug-loading and plasma stability by reducing the core crystallinity for intravenous delivery

(2018) Xuezhi Zhuo et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

mPEG5k-b-PLGA2k/PCL3.4k/MCT Mixed Micelles as Carriers of Disulfiram for Improving Plasma Stability and Antitumor Effect in Vivo

(2018) Linlin Miao et al.   MOLECULAR PHARMACEUTICS

A Smart Paclitaxel-Disulfiram Nanococrystals for Efficient MDR Reversal and Enhanced Apoptosis

(2018) Imran Shair Mohammad et al.   PHARMACEUTICAL RESEARCH

Synergistic breast tumor cell killing achieved by intracellular co-delivery of doxorubicin and disulfiram via core–shell–corona nanoparticles

(2018) Xiaoguang Tao et al.   Biomaterials Science

Drug-delivering-drug approach-based codelivery of paclitaxel and disulfiram for treating multidrug-resistant cancer

(2018) Imran Shair Mohammad et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

(2017) Mohammad Najlah et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer

(2017) Chenhui Wang et al.   International Journal of Nanomedicine

pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer

(2017) Qiang Huo et al.   International Journal of Nanomedicine

Polymeric micelles: Basic research to clinical practice

(2017) Anand S. Deshmukh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells

(2017) Zhipeng Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combining disulfiram and poly(l-glutamic acid)-cisplatin conjugates for combating cisplatin resistance

(2016) Wantong Song et al.   JOURNAL OF CONTROLLED RELEASE

The inhibitory effect of disulfiram encapsulated PLGA NPs on tumor growth: Different administration routes

(2016) Hamidreza Fasehee et al.   Materials Science & Engineering C-Materials for Biological Applications

Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line

(2016) Muddasarul Hoda et al.   Nanomedicine-Nanotechnology Biology and Medicine

Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy

(2016) Wantong Song et al.   Nanomedicine-Nanotechnology Biology and Medicine

Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations

(2016) Hamidreza Fasehee et al.   JOURNAL OF NANOBIOTECHNOLOGY

A Copper-Mediated Disulfiram-Loaded pH-Triggered PEG-Shedding TAT Peptide-Modified Lipid Nanocapsules for Use in Tumor Therapy

(2015) Ling Zhang et al.   ACS Applied Materials & Interfaces

Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β

(2015) Vikas Sharma et al.   MOLECULAR CARCINOGENESIS

Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice

(2015) YANHUI YANG et al.   Molecular Medicine Reports

Inhibitory effect of Disulfiram/copper complex on non-small cell lung cancer cells

(2014) Lincan Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate

(2014) Patrick Lai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram

(2014) Xiaopin Duan et al.   NANOTECHNOLOGY

Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram

(2013) Xiaopin Duan et al.   ACS Nano

Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells

(2013) P Liu et al.   BRITISH JOURNAL OF CANCER

How could a drug used to treat alcoholism also be effective against glioblastoma?

(2013) Weiguang Wang et al.   Expert Review of Anticancer Therapy

The Role of Copper in Disulfiram-Induced Toxicity and Radiosensitization of Cancer Cells

(2013) C. Rae et al.   JOURNAL OF NUCLEAR MEDICINE

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

(2012) P Liu et al.   BRITISH JOURNAL OF CANCER

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Targeting Malignancies with Disulfiram (Antabuse): Multidrug Resistance, Angiogenesis, and Proteasome

(2011) B. Cvek   CURRENT CANCER DRUG TARGETS

Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram)

(2011) Boris Cvek   DRUG DISCOVERY TODAY

Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives

(2011) Elisa Dalla Pozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma

(2010) Brian W. Morrison et al.   MELANOMA RESEARCH

On firm ground: IP protection of therapeutic nanoparticles

(2010) Paul Burgess et al.   NATURE BIOTECHNOLOGY

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

Impact of Nanotechnology on Drug Delivery

(2009) Omid C. Farokhzad et al.   ACS Nano

High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

(2009) K. Iljin et al.   CLINICAL CANCER RESEARCH