Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Chemistry, Multidisciplinary
Yonghui Qiao, Zhihao Wei, Tingting Qin, Rufeng Song, Zhiqiang Yu, Qi Yuan, Juan Du, Qingbing Zeng, Lanlan Zong, Shaofeng Duan, Xiaohui Pu
Summary: The hybrid nanosuspensions of HCPT and QUR have shown promising potential in reversing tumor drug resistance, enhancing therapeutic efficacy, reducing toxicity, and significantly increasing HCPT accumulation at tumor sites. Additionally, these nanosuspensions can enhance cytotoxicity to cancer cells and protect immune organs and normal tissues, making them a potential drug delivery system for improving cancer treatment.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sofija Jovanovic Stojanov, Epole N. Ntungwe, Jelena Dinic, Ana Podolski-Renic, Milica Pajovic, Patricia Rijo, Milica Pesic
Summary: Coleon U, a natural compound not recognized as a substrate of P-glycoprotein, has equal efficacy against sensitive and multidrug-resistant cancer cells. It delays the decrease in P-glycoprotein activity by decreasing mitochondrial membrane potential and inhibiting P-glycoprotein expression.
Retraction
Oncology
S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan, D. Velmurugan
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Biochemical Research Methods
Yuhong Cao, Yan Cao, Yiwei Shi, Ying Cai, Langdong Chen, Dongyao Wang, Yue Liu, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai
Summary: This study constructed a novel surface plasmon resonance-based P-gp ligand screening system combined with lentiviral particles to screen potential P-gp inhibitors from natural products. Positive compounds Valspodar and cyclosporin were used to characterize the system, and magnolol, honokiol, and resveratrol were identified as potential P-gp ligands. The method offers a faster screening process compared to traditional cell experiments and shows promise for screening membrane proteins using lentivirus-based technology.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pradhapsingh Bharathiraja, David S. P. Cardoso, N. Rajendra Prasad, Silva Mulhovo, Deepa S. Lakra, Maria-Jose U. Ferreira
Summary: This study found that derivatives of N-alkylated monoterpene indole alkaloids, particularly N-(para-bromobenzyl) (NBBT), can reverse P-gp-mediated multidrug resistance in cancer cells. NBBT exhibited the highest P-gp inhibitory activity and reduced P-gp overexpression by inhibiting the nuclear translocation of the nuclear factor kappa B p-50 subunit. Additionally, NBBT showed synergistic effects with doxorubicin, decreasing the cellular migration and increasing apoptotic incidence in drug-resistant cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Manuela Labbozzetta, Paola Poma, Monica Notarbartolo
Summary: Acute myeloid leukemia (AML) is difficult to treat due to the development of resistance to both traditional chemotherapy and new drugs in some patients. Multidrug resistance (MDR) in AML is often caused by the overexpression of P-glycoprotein (P-gp), which is an efflux pump. This mini-review focuses on the advantages of using natural substances as inhibitors of P-gp, including phytol, curcumin, lupeol, and heptacosane, and their mechanisms of action in AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yichen Tian, Yongrong Lei, Yani Wang, Jiejuan Lai, Jianhua Wang, Feng Xia
Summary: This review summarizes the mechanisms of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp), including the regulation of efflux activity, the inhibition of P-gp expression, and the knockout of the ABCB1 gene. Inhibiting P-gp through screening and designing suitable compounds and techniques can overcome P-gp-mediated MDR, providing a reference for studying the reversal of P-gp-mediated MDR.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
M. Ganesan, G. Kanimozhi, B. Pradhapsingh, Haseeb A. Khan, Abdullah S. Alhomida, Aishah Ekhzaimy, G. R. Brindha, N. Rajendra Prasad
Summary: The review discusses the role of natural phytochemicals in modulating ABCB1 gene expression through various signal transduction pathways in MDR cancer cells, suggesting an alternative approach to reversing MDR by downregulating P-glycoprotein expression in tumor tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Laura Mosca, Martina Pagano, Luigi Borzacchiello, Luigi Mele, Annapina Russo, Giulia Russo, Giovanna Cacciapuoti, Marina Porcelli
Summary: S-Adenosylmethionine (AdoMet) enhances the antitumor activity of 5-Fluorouracil (5-FU) in colorectal cancer cells by inhibiting autophagy, reversing drug resistance-related protein expression, and decreasing the activation level of the antiapoptotic factor NF-kappa B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiaohua Lu, Ge Yan, Mona Dawood, Sabine M. Klauck, Yoshikazu Sugimoto, Anette Klinger, Edmond Fleischer, Letian Shan, Thomas Efferth
Summary: MCC1381 is a moniliformin derivative that bypasses P-gp-mediated multidrug resistance, affects cell cycle and cellular death, and potentially inhibits histone deacetylases. In vitro studies show strong affinity of MCC1381 to HDAC6, leading to decreased expression and increased acetylation of HDAC6 substrates. Animal studies demonstrate anti-cancer activity of MCC1381 in xenografted zebrafish, suggesting its potential as a novel candidate for cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Agronomy
Tan Dai, Zhiwen Wang, Xingkai Cheng, Huige Gao, Li Liang, Pengfei Liu, Xili Liu
Summary: Both fungicide efflux and detoxification metabolism are involved in the resistance mechanisms of Phytophthora capsici to SYP-14288.
PEST MANAGEMENT SCIENCE
(2022)
Article
Oncology
Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh Ambudkar
Summary: In this study, we investigate the role of P-glycoprotein (P-gp) in the reduced sensitivity of cancer cells to the anaplastic lymphoma kinase (ALK) inhibitor ensartinib. Our results demonstrate that P-gp overexpression decreases the intracellular accumulation and cytotoxic activity of ensartinib in cancer cells. These findings highlight the importance of understanding the mechanisms of ensartinib resistance mediated by P-gp.
Article
Biochemistry & Molecular Biology
Yasmeen Cheema, Yusra Sajid Kiani, Kenneth J. J. Linton, Ishrat Jabeen
Summary: Researchers developed a pharmacophore model based on the cryo-EM structure of ABCB1 to screen for new inhibitors, resulting in the identification of six potential inhibitors with distinct chemistries and favorable properties. The compounds exhibited low nanomolar range inhibitory concentrations and two of them were able to resensitize ABCB1-expressing cells to taxol. This study demonstrates the utility of cryo-electron microscopy in drug identification and design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Kosheli Thapa Magar, George Frimpong Boafo, Xiaotong Li, Zhongjian Chen, Wei He
Summary: Biological drugs are limited in their application due to their inherent properties, but liposome-based drug delivery systems provide a promising solution to improve drug delivery.
CHINESE CHEMICAL LETTERS
(2022)
Review
Pharmacology & Pharmacy
Makhloufi Zoulikha, Qingqing Xiao, George Frimpong Boafo, Marwa A. Sallam, Zhongjian Chen, Wei He
Summary: siRNA has potential for treating acute lung injury/acute respiratory distress syndrome by modifying gene expression, but effective delivery remains a challenge.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Feifei Huang, Xiaohong Jiang, Marwa A. Sallam, Xingwang Zhang, Wei He
Summary: The preparation of drugs into nanocrystals is an important pharmaceutical technology to improve the solubility and bioavailability of poorly water-soluble drugs. This study presents a novel platform for nanocrystal production using a metal-phenolic network, which effectively wraps and stabilizes various drug nanocrystals. The platform shows promising potential for solving the low solubility challenge associated with hydrophobic drugs.
Article
Chemistry, Multidisciplinary
Qingqing Xiao, Xiaotong Li, Chang Liu, Yi Yang, Yuqi Hou, Ying Wang, Mengxiang Su, Wei He
Summary: In this study, a liposome-based co-delivery system was developed to simultaneously deliver pro-apoptotic protein and cytotoxic drug for synergistic cancer treatment. The system improved the solubility of the drug and achieved efficient drug delivery by targeting receptors on cancer cells. In vivo experiments demonstrated that the co-delivery system significantly inhibited tumor growth.
CHINESE CHEMICAL LETTERS
(2022)
Article
Pharmacology & Pharmacy
Ying Wang, Siyuan Xu, Ziyue Xiao, Yuxin Jiang, Qi Jiang, Jun Li, Wei He
Summary: This study aimed to improve the solubility and stability of stiripentol (STP), an insoluble and acid-labile drug, through the preparation of enteric solid dispersions and effervescent tablets. Results showed that the enteric amorphous STP-SDs significantly improved the solubility and stability of STP. The bioavailability of STP-SD-ETs was as high as 138.71% and the intestinal absorption rate of STP was increased. This oral preparation combining enteric solid dispersion and effervescent tablet technology provides a promising method to enhance the delivery of drugs with poor solubility and acid-labile stability.
Review
Chemistry, Multidisciplinary
Makhloufi Zoulikha, Wei He
Summary: Chronic lymphocytic leukemia (CLL) is an incurable disorder that requires innovative therapeutic strategies and improved drug delivery process for better treatment effectiveness. This review discusses the use of different types of nanocarriers in fighting against CLL and their features.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Qingqing Xiao, Xiaotong Li, Chang Liu, Yuxin Jiang, Yonglong He, Wanting Zhang, Helena S. Azevedo, Wei Wu, Yuanzheng Xia, Wei He
Summary: In this study, researchers combined a targeted diterpenoid derivative with an anti-CTLA-4 checkpoint blockade to improve immunotherapy. The use of thermosensitive liposomes as carriers allowed for the co-delivery of the two drug payloads into the tumor, resulting in enhanced immune response and therapeutic effect. Additionally, the diterpenoid derivative also improved the immunotherapeutic effect of the anti-PD-1 checkpoint antibody.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Wanting Zhang, Yuxin Jiang, Yonglong He, Hamza Boucetta, Jun Wu, Zhongjian Chen, Wei He
Summary: This study provides an overview of the applications of lipid carriers in mRNA delivery and the development of lipid-based formulations as vaccine delivery systems, with a focus on the recent advancements in COVID-19 mRNA vaccines. It highlights the significance of these advancements in developing effective vaccines and treatment methods.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Bingbing Li, Chao Teng, Huiling Yu, Xiaohong Jiang, Xuyang Xing, Qi Jiang, Chenshi Lin, Zongmin Zhao, Ruifeng Zhang, Wei He
Summary: In this study, a targeted co-delivery system was developed to alleviate pulmonary hypertension (PH) by inhibiting pulmonary artery smooth muscle cell (PASMC) proliferation and promoting apoptosis. The system effectively targeted PASMCs and regressed pulmonary artery remodeling, leading to improved hemodynamics and decreased pulmonary arterial pressure.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Yangyang Xie, Xiaotong Li, Jingyi Wu, Huiling Zeng, Hamza Boucetta, Binru Wang, Pei Yang, Wei He
Summary: This article summarizes the innovative strategy of adoptive immunotherapy through in vitro modifications to express synthetic chimeric antigen receptors (CAR) on T cells for cancer treatment. This approach allows T cells to recognize and bind tumor antigens via a single-chain variable fragment recognition domain, bypassing the restriction of major histocompatibility complex. The article reviews the structure/design of CAR-T cells, the evolution process of this technology, the theoretical foundation for CAR-T therapy, marketed products, and the latest preclinical and clinical research progress. Perspectives on the development and potential future applications of this technology, especially for hematological malignant and solid tumors, are also provided.
CHINESE CHEMICAL LETTERS
(2023)
Article
Pharmacology & Pharmacy
Yi Yang, Makhloufi Zoulikha, Qingqing Xiao, Feifei Huang, Qi Jiang, Xiaotong Li, Zhenfeng Wu, Wei He
Summary: This study developed a pulmonary endothelium-targeted codelivery system that can simultaneously deliver anti-inflammatory and antioxidant drugs, with high drug loading and the ability to target pulmonary endothelial cells. In vitro and in vivo experiments demonstrated the synergistic anti-inflammatory and antioxidant effects of the formulation, highlighting its importance in alleviating lung inflammation and improving lung health.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Yuanchao Jia, Yuxin Jiang, Yonglong He, Wanting Zhang, Jiahui Zou, Kosheli Thapa Magar, Hamza Boucetta, Chao Teng, Wei He
Summary: Nanomedicine is a branch of medicine that uses nanotechnology for disease prevention and treatment. It has revolutionized medicine by improving drug efficacy, reducing toxicity, and targeting drug delivery. Nanomedicine has shown significant potential in treating major diseases like cancer, infections, and cardiovascular diseases. Although clinical implementation is still limited, the use of nanoscale drugs is increasingly being explored to minimize side effects and improve therapeutic outcomes.
Review
Biochemistry & Molecular Biology
Mingyang Ma, Huiling Zeng, Pei Yang, Jiabing Xu, Xingwang Zhang, Wei He
Summary: With the increase in the aging population, there is a growing risk of osteoporosis. The use of anti-osteoporosis drugs in clinical settings is currently hindered by recurring side effects and poor patient compliance, regardless of the method of administration. Utilizing drug delivery systems or formulation strategies can target drug delivery to the bones, reduce side effects, improve bioavailability, and prolong the effectiveness of treatment. This review focuses on the pathogenesis of osteoporosis, clinical medications used for intervention, the design approach for drug delivery, and emerging novel drug delivery systems for osteoporosis treatment. These findings contribute to the engineering of anti-osteoporosis drug delivery and targeted therapy.
Article
Engineering, Biomedical
Waqas Nawaz, Muhammad Naveed, Jing Zhang, Sobia Noreen, Muhammad Saeed, Kiganda Raymond Sembatya, Awais Ullah Ihsan, Imran Shair Mohammad, Gang Wang, Xiaohui Zhou
Summary: This study evaluates the feasibility and cardio-protective effects of a biocompatible silicon-built restraint device (ASD) in a rat model of heart failure. The results show that the ASD device is safe and effective in attenuating ventricular remodeling and improving heart function. Furthermore, ASD treatment reduces myocardial fibrosis, indicating significant therapeutic effects.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Oncology
Hafiz Muhammad Ishaq, Imran Shair Mohammad, Riaz Hussain, Rashida Parveen, Jafir Hussain Shirazi, Yang Fan, Muhammad Shahzad, Khezar Hayat, Huan Li, Ayesha Ihsan, Kiran Sher Muhammad, Muhammad Usman, Siruo Zhang, Lu Yuan, Shakir Ullah, Ana Claudia Paiva-Santos, Jiru Xu
Summary: This study investigated the changes in gut bacterial composition in thyroid cancer patients and found significant dysbiosis in the gut microbiota of euthyroid thyroid cancer patients. The results suggest that this study may propose new approaches to understanding the disease pathways, mechanisms, and treatment of thyroid cancer patients.