An “Amyloid‐β Cleaner” for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction

Metal-Organic Frameworks Harness Cu Chelating and Photooxidation Against Amyloid β Aggregation in vivo

(2019) Xiaogang Qu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

(2019) Daniel Felsky et al.   Nature Communications

Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood-Brain Barrier Permeability Upregulating Nanoparticle

(2019) Liming Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Chirality-Selected Chemical Modulation of Amyloid Aggregation

(2019) Nan Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light‐Activated Fluorescence Amplification and Phototherapy

(2019) Yun Chang et al.   Advanced Science

Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment

(2018) Chenmeng Qiao et al.   ADVANCED MATERIALS

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

(2018) Anjali Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy

(2018) Yan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates

(2018) Pierpaolo Moscariello et al.   Advanced Science

Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide

(2018) Yijia Guan et al.   Science Advances

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

(2018) Joseph Flores et al.   Nature Communications

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

(2016) Ran Zhang et al.   ADVANCED MATERIALS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway

(2016) Jiamin Mao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease

(2016) Nurgul Aytan et al.   Scientific Reports

Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

(2015) Bingbing Hu et al.   ADVANCED MATERIALS

Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior

(2015) Yan Li et al.   BIOMATERIALS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid

(2015) Margherita Eufemi et al.   NEUROCHEMISTRY INTERNATIONAL

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition

(2015) Meng Li et al.   Small

Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon

(2015) Yan Li et al.   Theranostics

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy

(2014) Yan Li et al.   BIOMATERIALS

The role of glucose transporters in the distribution of p-aminophenyl-α-d-mannopyranoside modified liposomes within mice brain

(2014) Dan Du et al.   JOURNAL OF CONTROLLED RELEASE

Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice

(2013) Ruchi Roy et al.   INTERNATIONAL IMMUNOLOGY

Aβ-induced microglial cell activation is inhibited by baicalin through the JAK2/STAT3 signaling pathway

(2013) Jiaxiang Xiong et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA

(2013) Yan Li et al.   JOURNAL OF CONTROLLED RELEASE

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fingolimod phosphate promotes the neuroprotective effects of microglia

(2013) Hiromi Noda et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Endosomal escape and transfection efficiency of PEGylated cationic liposome–DNA complexes prepared with an acid-labile PEG-lipid

(2012) Chia-Ling Chan et al.   BIOMATERIALS

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

(2012) Shao-wei Wang et al.   NEUROTOXICOLOGY

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice

(2009) Misa Matsumura et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY