Ketamine and Active Ketamine Metabolites Regulate STAT3 and the Type I Interferon Pathway in Human Microglia: Molecular Mechanisms Linked to the Antidepressant Effects of Ketamine

Sex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression

(2019) Marlene P. Freeman et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

(2018) Ming-Fen Ho et al.   BIOCHEMICAL PHARMACOLOGY

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

(2R,6R)-Hydroxynorketamine promotes dendrite outgrowth in human inducible pluripotent stem cell-derived neurons through AMPA receptor with timing and exposure compatible with ketamine infusion pharmacokinetics in humans

(2018) Ginetta Collo et al.   NEUROREPORT

Ketamine increases the expression of GluR1 and GluR2 α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor subunits in human dopaminergic neurons differentiated from induced pluripotent stem cells

(2018) Ginetta Collo et al.   NEUROREPORT

Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses

(2017) Gemma McGregor et al.   FASEB JOURNAL

Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders

(2017) C A Zarate et al.   MOLECULAR PSYCHIATRY

Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions

(2017) Sun-Ho Kwon et al.   NEUROPSYCHOPHARMACOLOGY

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation

(2017) Subhash K. Tripathi et al.   Cell Reports

Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome

(2017) D D Kiraly et al.   Translational Psychiatry

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

(2016) Ambalika Sarkar et al.   BIOLOGICAL PSYCHIATRY

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

(2016) M M Harraz et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

(2016) Michael S Patton et al.   NEUROPSYCHOPHARMACOLOGY

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

(2016) D M Rotroff et al.   Translational Psychiatry

Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression

(2015) Jian-jun Yang et al.   BIOLOGICAL PSYCHIATRY

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Antidepressant mechanism of ketamine: perspective from preclinical studies

(2015) Lisa Scheuing et al.   Frontiers in Neuroscience

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

(2013) Georges Mion et al.   CNS Neuroscience & Therapeutics

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties

(2013) P A Zunszain et al.   MOLECULAR PSYCHIATRY

The role of eEF2 pathway in learning and synaptic plasticity

(2013) Elham Taha et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Sex differences in the antidepressant-like effects of ketamine

(2013) Nicole Carrier et al.   NEUROPHARMACOLOGY

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine

(2012) Lisa M. Monteggia et al.   BIOLOGICAL PSYCHIATRY

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

(2012) Xiaochen Zhao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

(2012) Laura Icardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The increasing burden of depression

(2011) Mike Briley et al.   Neuropsychiatric Disease and Treatment

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

(2010) G. E. Gillies et al.   PHARMACOLOGICAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE