Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

Multiple functions of α-catenin beyond cell adhesion regulation

(2018) Masatoshi Takeichi   CURRENT OPINION IN CELL BIOLOGY

Upstairs, downstairs: spatial regulation of Hippo signalling

(2018) Alexander Fulford et al.   CURRENT OPINION IN CELL BIOLOGY

Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner

(2018) Jiajie Xu et al.   DEVELOPMENTAL CELL

The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis

(2018) William Razzell et al.   JOURNAL OF CELL BIOLOGY

Tension-dependent regulation of mammalian Hippo signaling through LIMD1

(2018) Consuelo Ibar et al.   JOURNAL OF CELL SCIENCE

Salt bridges gate α-catenin activation at intercellular junctions

(2018) Samantha Barrick et al.   MOLECULAR BIOLOGY OF THE CELL

The Hippo Signaling Network and its Biological Functions

(2018) Jyoti R. Misra et al.   Annual Review of Genetics

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics

(2018) Diana Pinheiro et al.   DEVELOPMENTAL CELL

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

(2018) Noboru Ishiyama et al.   Nature Communications

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

(2018) Girish R. Kale et al.   Nature Communications

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

(2017) Sarah P. Short et al.   JOURNAL OF CLINICAL INVESTIGATION

Forces shaping the Drosophila wing

(2017) M.C. Diaz de la Loza et al.   MECHANISMS OF DEVELOPMENT

Forces controlling organ growth and size

(2017) Dominik Eder et al.   MECHANISMS OF DEVELOPMENT

Mechanosensing and Mechanotransduction at Cell–Cell Junctions

(2017) Alpha S. Yap et al.   Cold Spring Harbor Perspectives in Biology

Cell Junctions in Hippo Signaling

(2017) Ruchan Karaman et al.   Cold Spring Harbor Perspectives in Biology

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions

(2017) René Marc Mège et al.   Cold Spring Harbor Perspectives in Biology

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Differential growth triggers mechanical feedback that elevates Hippo signaling

(2016) Yuanwang Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New functions for alpha-catenins in health and disease: from cancer to heart regeneration

(2015) Alexia Vite et al.   CELL AND TISSUE RESEARCH

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Dynamic Visualization of α-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States

(2015) Tae-Jin Kim et al.   CURRENT BIOLOGY

JNK signaling is converted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity

(2015) Masato Enomoto et al.   DEVELOPMENTAL BIOLOGY

Organ Size Control: Lessons from Drosophila

(2015) Iswar K. Hariharan   DEVELOPMENTAL CELL

Differential regulation of the Hippo pathway by adherens junctions and apical–basal cell polarity modules

(2015) Chih-Chao Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localization of Hippo signalling complexes and Warts activation in vivo

(2015) Shuguo Sun et al.   Nature Communications

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

α-catenin

(2014) Yutong Sun et al.   CELL CYCLE

The Hippo-YAP signaling pathway and contact inhibition of growth

(2014) Barry M. Gumbiner et al.   JOURNAL OF CELL SCIENCE

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Three Functions of Cadherins in Cell Adhesion

(2013) Jean-Léon Maître et al.   CURRENT BIOLOGY

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling

(2013) P. Khoo et al.   Disease Models & Mechanisms

An Autoinhibited Structure of α-Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions

(2013) Noboru Ishiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric α-catenin links cadherin to the actin cytoskeleton

(2013) Ridhdhi Desai et al.   NATURE CELL BIOLOGY

The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway

(2012) Tao Yue et al.   DEVELOPMENTAL CELL

Mutational analysis supports a core role for Drosophila  -Catenin in adherens junction function

(2012) R. Sarpal et al.   JOURNAL OF CELL SCIENCE

 E-catenin is an autoinhibited molecule that coactivates vinculin

(2012) H.-J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/Wingless Signaling in Drosophila

(2012) S. Swarup et al.   Cold Spring Harbor Perspectives in Biology

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila

(2011) G. Kolahgar et al.   DEVELOPMENT

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Identification of Novel Ras-Cooperating Oncogenes inDrosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

(2011) Anthony M. Brumby et al.   GENETICS

Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome

(2011) D. Sabino et al.   JOURNAL OF CELL SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane

(2010) Amanda L. Neisch et al.   JOURNAL OF CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Bench to bedside and back again: Molecular mechanisms of α-catenin function and roles in tumorigenesis

(2007) Jacqueline M. Benjamin et al.   SEMINARS IN CANCER BIOLOGY