YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

(2016) Bo Liu et al.   CELL

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conservation of Planar Polarity Pathway Function Across the Animal Kingdom

(2015) Rosalind Hale et al.   Annual Review of Genetics

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Zyxin Antagonizes the FERM Protein Expanded to Couple F-Actin and Yorkie-Dependent Organ Growth

(2015) Pedro Gaspar et al.   CURRENT BIOLOGY

StromalFat4acts non-autonomously withDchs1/2to restrict the nephron progenitor pool

(2015) Mazdak Bagherie-Lachidan et al.   DEVELOPMENT

Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development

(2015) C. Badouel et al.   DEVELOPMENT

Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway

(2015) Hailey J. Kwon et al.   DEVELOPMENTAL BIOLOGY

Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions

(2015) Yao Wu et al.   DEVELOPMENTAL CELL

Distinct Polarity Cues Direct Taz/Yap and TGFβ Receptor Localization to Differentially Control TGFβ-Induced Smad Signaling

(2015) Masahiro Narimatsu et al.   DEVELOPMENTAL CELL

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

(2015) Flore Nallet-Staub et al.   DEVELOPMENTAL CELL

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

(2015) Aleksander D. Szymaniak et al.   DEVELOPMENTAL CELL

Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts

(2015) Alina M. Vrabioiu et al.   DEVELOPMENTAL CELL

The Spectrin cytoskeleton regulates the Hippo signalling pathway

(2015) G. C. Fletcher et al.   EMBO JOURNAL

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes

(2015) Karin Grannas et al.   JOURNAL OF MOLECULAR BIOLOGY

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Localization of Hippo signalling complexes and Warts activation in vivo

(2015) Shuguo Sun et al.   Nature Communications

Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie

(2015) Joseph Parker et al.   PLOS BIOLOGY

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

(2015) Hua Deng et al.   eLife

Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration

(2014) James L. Grijalva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila

(2014) M. Rodrigues-Campos et al.   DEVELOPMENT

Membrane tension drives ligand-independent integrin signaling

(2014) R. T. Bottcher et al.   EMBO JOURNAL

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

(2014) Z. Guo et al.   Science Signaling

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling

(2014) Tobias Speicher et al.   Nature Communications

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

(2014) Justin A Bosch et al.   eLife

Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma

(2014) Su-xia Han et al.   Journal of Immunology Research

Drosophila Perlecan Regulates Intestinal Stem Cell Activity via Cell-Matrix Attachment

(2014) Jia You et al.   Stem Cell Reports

G protein-coupled receptors engage the mammalian Hippo pathway through F-actin

(2013) Laura Regué et al.   BIOESSAYS

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP

(2013) Leticia Sansores-Garcia et al.   CURRENT BIOLOGY

Mask Proteins Are Cofactors of Yorkie/YAP in the Hippo Pathway

(2013) Clara M. Sidor et al.   CURRENT BIOLOGY

A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc

(2013) Loïc LeGoff et al.   DEVELOPMENT

Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway

(2013) Covadonga F. Hevia et al.   DEVELOPMENTAL BIOLOGY

Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila

(2013) Guonan Lin et al.   DEVELOPMENTAL BIOLOGY

Differential proliferation rates generate patterns of mechanical tension that orient tissue growth

(2013) Yanlan Mao et al.   EMBO JOURNAL

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Riquiqui and Minibrain are regulators of the Hippo pathway downstream of Dachsous

(2013) Joffrey L. Degoutin et al.   NATURE CELL BIOLOGY

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene

(2013) B G Fernández et al.   ONCOGENE

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ajuba Family Proteins Link JNK to Hippo Signaling

(2013) G. Sun et al.   Science Signaling

Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

(2013) Yunyun Jin et al.   eLife

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous

(2012) Amy Brittle et al.   CURRENT BIOLOGY

Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development

(2012) Natalia A Bulgakova et al.   CURRENT OPINION IN CELL BIOLOGY

Intestinal stem cell function in Drosophila and mice

(2012) Huaqi Jiang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity

(2012) G. Struhl et al.   DEVELOPMENT

Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size

(2012) T. Aegerter-Wilmsen et al.   DEVELOPMENT

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

(2012) Katrin Straßburger et al.   DEVELOPMENTAL BIOLOGY

Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries

(2012) Yassi Hafezi et al.   DEVELOPMENTAL BIOLOGY

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila

(2012) Masato Enomoto et al.   EMBO REPORTS

Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)

(2012) J.-S. Mo et al.   GENES & DEVELOPMENT

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

(2012) S. R. Coyer et al.   JOURNAL OF CELL SCIENCE

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

(2012) F. Bosveld et al.   SCIENCE

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador–Warts–Hippo pathway

(2011) X Zhang et al.   CELL DEATH AND DIFFERENTIATION

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

(2011) Vicki P. Losick et al.   DEVELOPMENTAL CELL

Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila

(2011) Y. Mao et al.   GENES & DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

(2010) Binnaz Kucuk Staley et al.   CURRENT BIOLOGY

Upstream Regulation of the Hippo Size Control Pathway

(2010) Felix A. Grusche et al.   CURRENT BIOLOGY

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

(2010) R. L. Shaw et al.   DEVELOPMENT

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

(2010) P. Karpowicz et al.   DEVELOPMENT

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

(2010) Felix A. Grusche et al.   DEVELOPMENTAL BIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

(2010) S W Chan et al.   ONCOGENE

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS