Notch signalling in T cell homeostasis and differentiation

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

(2019) Jelena Petrovic et al.   MOLECULAR CELL

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Notch-1 Inhibition Promotes Immune Regulation in Transplantation via Treg-Dependent Mechanisms

(2019) Ciara N. Magee et al.   CIRCULATION

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease

(2019) Jooho Chung et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Notch signaling mediated by Delta-like1/4 ligands controls the pathogenesis of chronic graft-versus-host disease in mice

(2018) Vedran Radojcic et al.   BLOOD

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

(2017) Jooho Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

T Cell–Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity duringCryptococcus neoformansInfection

(2017) Lori M. Neal et al.   JOURNAL OF IMMUNOLOGY

Common nonmutationalNOTCH1activation in chronic lymphocytic leukemia

(2017) Giulia Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

(2017) Russell J.H. Ryan et al.   Cell Reports

Targeting the Notch Pathway to Prevent Rejection

(2016) J. Chung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advances in understanding the pathogenesis of graft-versus-host disease

(2016) John Magenau et al.   BRITISH JOURNAL OF HAEMATOLOGY

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

(2016) P Bernasconi-Elias et al.   ONCOGENE

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

Notch Signaling Regulates Antigen Sensitivity of Naive CD4+ T Cells by Tuning Co-stimulation

(2015) Karen Laky et al.   IMMUNITY

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

(2015) Vionnie W.C. Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transient Blockade of Delta-like Notch Ligands Prevents Allograft Rejection Mediated by Cellular and Humoral Mechanisms in a Mouse Model of Heart Transplantation

(2015) Sherri Wood et al.   JOURNAL OF IMMUNOLOGY

The Notch Signaling Pathway Controls Short-Lived Effector CD8+T Cell Differentiation but Is Dispensable for Memory Generation

(2015) Mélissa Mathieu et al.   JOURNAL OF IMMUNOLOGY

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling

(2015) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Notch in T Cell Differentiation: All Things Considered

(2015) Derk Amsen et al.   TRENDS IN IMMUNOLOGY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Overexpression of Jagged-1 combined with blockade of CD40 pathway prolongs allograft survival

(2014) Yingying Lin et al.   IMMUNOLOGY AND CELL BIOLOGY

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of Th2 Cell Development by Notch Ligands Delta1 and Delta4

(2014) J. Sun et al.   JOURNAL OF IMMUNOLOGY

Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase C  and Attenuates Experimental Autoimmune Encephalomyelitis

(2014) M. Jurynczyk et al.   JOURNAL OF IMMUNOLOGY

Notch3 Activation Is Sufficient but Not Required for Inducing Human T-Lineage Specification

(2014) Els Waegemans et al.   JOURNAL OF IMMUNOLOGY

A central role for Notch in effector CD8+ T cell differentiation

(2014) Ronald A Backer et al.   NATURE IMMUNOLOGY

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

(2014) Hyun Mu Shin et al.   Frontiers in Immunology

Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals

(2013) Will Bailis et al.   IMMUNITY

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

(2013) Justine E. Roderick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell-Specific Notch Inhibition Blocks Graft-versus-Host Disease by Inducing a Hyporesponsive Program in Alloreactive CD4+ and CD8+ T Cells

(2013) A. R. Sandy et al.   JOURNAL OF IMMUNOLOGY

Delta-like Ligand 4 Identifies a Previously Uncharacterized Population of Inflammatory Dendritic Cells That Plays Important Roles in Eliciting Allogeneic T Cell Responses in Mice

(2013) K. Mochizuki et al.   JOURNAL OF IMMUNOLOGY

Notch Signaling Regulates Follicular Helper T Cell Differentiation

(2013) F. Auderset et al.   JOURNAL OF IMMUNOLOGY

Notch Signaling Regulates T Cell Accumulation and Function in the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2013) A. R. Sandy et al.   JOURNAL OF IMMUNOLOGY

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

(2013) Michael J. Kluk et al.   PLoS One

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Notch receptors and ligands on immature and mature T cells

(2012) Akemi Koyanagi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

(2012) S.-U. Lee et al.   BLOOD

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells

(2012) Wassim Elyaman et al.   IMMUNITY

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Notch controls the magnitude of T helper cell responses by promoting cellular longevity

(2012) C. Helbig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major

(2012) Floriane Auderset et al.   PLoS Pathogens

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

(2011) W. Zheng et al.   BLOOD

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

(2011) K. Niessen et al.   BLOOD

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

(2011) D. Rossi et al.   BLOOD

Blockade of Notch Ligand Delta1 Promotes Allograft Survival by Inhibiting Alloreactive Th1 Cells and Cytotoxic T Cell Generation

(2011) L. V. Riella et al.   JOURNAL OF IMMUNOLOGY

Notch Ligand Delta-Like 4 Blockade Alleviates Experimental Autoimmune Encephalomyelitis by Promoting Regulatory T Cell Development

(2011) R. Bassil et al.   JOURNAL OF IMMUNOLOGY

Notch3 and Canonical NF- B Signaling Pathways Cooperatively Regulate Foxp3 Transcription

(2011) A. Barbarulo et al.   JOURNAL OF IMMUNOLOGY

Genetic and Functional Evidence Implicating DLL1 as the Gene That Influences Susceptibility to Visceral Leishmaniasis at Chromosome 6q27

(2011) Michaela Fakiola et al.   JOURNAL OF INFECTIOUS DISEASES

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection

(2011) Toshihiro Ito et al.   PLoS Pathogens

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

(2009) Y. Yashiro-Ohtani et al.   GENES & DEVELOPMENT

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

(2009) Joanne B. Tan et al.   IMMUNITY

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

(2009) Sara González-García et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of T Cell Activation by Notch Ligand, DLL4, Promotes IL-17 Production and Rorc Activation

(2009) S. Mukherjee et al.   JOURNAL OF IMMUNOLOGY

Notch1 and TGF 1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

(2008) J. B. Samon et al.   BLOOD

Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms

(2008) Thorsten B. Feyerabend et al.   IMMUNITY

Delta-like 4 is indispensable in thymic environment specific for T cell development

(2008) Katsuto Hozumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

(2008) Ute Koch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The earliest thymic progenitors for T cells possess myeloid lineage potential

(2008) J. Jeremiah Bell et al.   NATURE

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

(2008) Yoichi Maekawa et al.   NATURE IMMUNOLOGY

Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition

(2008) Chin-Tong Ong et al.   PLoS One

Overcoming failure to repair demyelination in EAE: γ-secretase inhibition of Notch signaling

(2007) Maciej Jurynczyk et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES