Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson’s Disease

Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

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Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

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Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice

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Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

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Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway

(2018) Jiting Yan et al.   PHARMACOLOGICAL RESEARCH

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

(2018) Zhuo Wang et al.   Frontiers in Aging Neuroscience

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

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Possible role of miR-204 in optic nerve injury through the regulation of GAP-43

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Catalpol Protects Pre-Myelinating Oligodendrocytes against Ischemia-induced Oxidative Injury through ERK1/2 Signaling Pathway

(2016) Qiyan Cai et al.   International Journal of Biological Sciences

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Catalpol ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by suppressing the JNK and NF-κB pathways

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Parkinson's disease

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Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice

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Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

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Inflammation in Parkinson’s disease: role of glucocorticoids

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Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson׳s disease

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Neurons Limit Angiogenesis by Titrating VEGF in Retina

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Protective Effects of Salidroside in the MPTP/MPP+-Induced Model of Parkinson's Disease through ROS–NO-Related Mitochondrion Pathway

(2014) Songhai Wang et al.   MOLECULAR NEUROBIOLOGY

Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease

(2014) Maciej Świątkiewicz et al.   Pharmacological Reports

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

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Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by d-galactose

(2013) Xiuli Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol

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The Function of α-Synuclein

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Microglia: New Roles for the Synaptic Stripper

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In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex

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Autophagy and apoptosis dysfunction in neurodegenerative disorders

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Meta-analysis of early nonmotor features and risk factors for Parkinson disease

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Resveratrol potentiates cytochrome P450 2d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse

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HPLC–APCI–MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: Application to an in vivo pharmacokinetic study

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Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

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IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

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Behavioral phenotyping of mouse models of Parkinson's disease

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Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

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MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

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Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum

(2010) G. Xu et al.   NEUROSCIENCE

Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine

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Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

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Serum levels of interleukin-6 are elevated in patients with Parkinson's disease and correlate with physical performance

(2009) Paula Scalzo et al.   NEUROSCIENCE LETTERS

Viral parkinsonism

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Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

(2008) Xuesong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons

(2008) Jing Bi et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity

(2008) Bo Jiang et al.   NEUROLOGICAL RESEARCH

Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures

(2008) Jing Bi et al.   NEUROSCIENCE LETTERS

Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity

(2008) Jing Bi et al.   TOXICOLOGY IN VITRO