Article
Biochemistry & Molecular Biology
Patrick Schaedel, Fabiana Troisi, Anna Czapka, Nadja Gebert, Simona Pace, Alessandro Ori, Oliver Werz
Summary: Aging is often accompanied by chronic systemic inflammation, referred to as inflammaging, which plays a major role in age-associated diseases. Research shows that different organs have organ-specific responses to inflammatory cytokines, chemokines, and lipid mediators, with varying levels of pro-inflammatory and pro-resolving mediators during the aging process.
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Chemistry, Medicinal
Jinyao Liu, Shuang Liu, Mingyue Yu, Jianing Li, Zunxuan Xie, Boyang Gao, Yuyan Liu
Summary: Catalpol is an iridoid glucoside with anti-inflammatory effects, mainly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has been shown to have anti-inflammatory effects in various diseases, such as neurological diseases, atherosclerosis, renal diseases, respiratory diseases, digestive diseases, bone and joint diseases, eye diseases, and periodontitis. This review aims to summarize the literature on the anti-inflammatory effects of catalpol in a variety of inflammatory diseases over the last decade and focus on its anti-inflammatory mechanisms.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ivan Emmanuel Ramos-Martinez, Maria Carmen Rodriguez, Marco Cerbon, Juan Carlos Ramos-Martinez, Edgar Gustavo Ramos-Martinez
Summary: In various central nervous system diseases, inflammation has been linked to the etiologic process, prompting research on using cholinergic agonists and vagus nerve stimulation for treatment and inflammation control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Min-Hee Kang, Yu Jin Kim, Min Jeong Cho, Juyi Jang, Yun Dong Koo, Soon Ha Kim, Jae Ho Lee
Summary: This study investigated the effect of MIT-001 on aged ovarian function, showing that MIT-001 enhanced follicle numbers and downregulated immune response-related genes and cytokines in old mice ovaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Apala Chakraborty, Soumyabrata Banerjee, Biswajit Mukherjee, Mrinal K. Poddar, Nahid Ali
Summary: The study shows that dietary calorie restriction for one and two consecutive months can significantly attenuate aging-related immune system changes, such as decreased lymphocyte viability and increased DNA fragmentation in blood, spleen, and thymus, as well as increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Song, Jin Chung, Grzegorz Wegrzyn
Summary: This study found that the relative abundance of Porphyromonas gingivalis (P. gingivalis) was significantly higher in periodontitis patients, especially in the elderly. The inflammatory response to P. gingivalis infection was greater in older individuals, and they also experienced more severe bone loss. These findings enhance understanding of the relationship between periodontal immunosenescence and inflammatory response in the elderly.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Geriatrics & Gerontology
Roberta Benfante, Simona Di Lascio, Silvia Cardani, Diego Fornasari
Summary: Neuroinflammation and cholinergic dysfunction are characteristics of aging and neurodegenerative disorders, such as Alzheimer's disease. Acetylcholinesterase inhibitors are symptomatic therapy for AD, improving cognitive deficits by enhancing cholinergic synapses. The alpha 7 nicotinic acetylcholine receptor has a dual role in promoting inflammation and neuroprotection, playing a crucial role in regulating cognitive function.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Geriatrics & Gerontology
Michel Lopez-Teros, Adriana Alarcon-Aguilar, Norma Edith Lopez-Diazguerrero, Armando Luna-Lopez, Mina Konigsberg
Summary: Astrocytes in the aging central nervous system have both neuroprotective and neurotoxic functions, contributing to chronic inflammation and impaired cognitive function. The secretomes of senescent and reactive astrocytes have not been directly compared in the aging brain.
Article
Psychiatry
Ya-lin Wang, Hao-ran Wu, Shan-shan Zhang, Hong-lei Xiao, Jin Yu, Yuan-yuan Ma, Yao-dong Zhang, Qiong Liu
Summary: The study confirmed that catalpol exhibits antidepressive effects on CUMS mice by inhibiting NLRP3 and neuroinflammation. Moreover, mitochondrial oxidative stress activity may be associated with NLRP3 activation.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Aysenur Karaduman, Elif Tugce Karoglu-Eravsar, Utku Kaya, Alaz Aydin, Michelle M. Adams, Hulusi Kafaligonul
Summary: Understanding the principles underlying age-related changes in motion perception is crucial for improving the quality of life and health of older adults. The study found that age and genotype had no significant main effects, but there was a significant three-way interaction between contrast level, age, and genotype in optomotor responses. These findings suggest a complex relationship between visual motion characteristics and the cholinergic system during neural aging.
NEUROBIOLOGY OF AGING
(2021)
Review
Biochemistry & Molecular Biology
Rachid Mahmoudi, Jean Luc Novella, Sarah Laurent-Badr, Sarah Boulahrouz, David Tran, Isabella Morrone, Yacine Jaidi
Summary: Cholinergic antagonists interfere with synaptic transmission in the central nervous system and are involved in pathological processes in patients with neurocognitive disorders (NCD), such as behavioral and psychological symptoms of dementia (BPSD). In this commentary, we review the impact of cholinergic burden on BPSD in NCD patients, including the main pathophysiological mechanisms. Given the lack of consensus on symptomatic management of BPSD, attention should be paid to this preventable, iatrogenic condition in NCD patients, and de-prescription of cholinergic antagonists should be considered for patients with BPSD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shima Torkzadeh-Mahani, Mehdi Abbasnejad, Maryam Raoof, Ghizlane Aarab, Saeed Esmaeili-Mahani, Frank Lobbezoo
Summary: Dental pain in the elderly population presents challenges for healthcare services, but the underlying molecular mechanisms and age-induced alterations in dental pain perception are not fully understood. This study evaluated the effects of aging on nociceptive behaviors in rats with inflammatory dental pulp pain. It was found that aged rats exhibited a different pattern of pain compared to young rats, with prolonged and increased nociceptive behaviors. Molecular analysis revealed increased expression of pro-inflammatory factors in the trigeminal ganglion, indicating a potential role in the increased pain perception in aged rats.
Review
Immunology
Khalil Hajiasgharzadeh, Alireza Khabbazi, Ahad Mokhtarzadeh, Amir Baghbanzadeh, Zahra Asadzadeh, Elham Adlravan, Behzad Baradaran
Summary: Connective tissue diseases (CTDs) encompass a wide range of heterogeneous conditions caused by immune-mediated inflammation affecting various connective tissues, including rheumatoid arthritis and systemic lupus erythematosus. The intrinsic cholinergic anti-inflammatory pathway (CAP) has been investigated for its potential in modulating chronic inflammation, but the presence of autonomic neuropathy in CTDs may affect its effectiveness. Further research is needed to explore the benefits and limitations of CAP in controlling inflammatory responses and treating CTDs.
INFLAMMOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulain
Summary: This study aimed to investigate the impact of chronic consumption of fluoride contained groundwater on human subjects. Through examination and analysis of 512 volunteers from different areas of Pakistan, it was found that participants from fluoride endemic areas exhibited symptoms of dental and skeletal fluorosis. Cholinergic enzymes, ACHE gene 3'-UTR variant, and BCHE K-variant were identified to be associated with the risk of fluorosis. Increased levels of pro-inflammatory cytokines were also observed, which had a significant correlation with fluoride exposure and cholinergic enzymes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Xiuli Zhang, Chunli Li, Jun Li, Yingzhen Xu, Shui Guan, Mingshan Zhao
INTERNATIONAL IMMUNOPHARMACOLOGY
(2015)
Article
Developmental Biology
Shui Guan, Jianqiang Xu, Yifu Guo, Dan Ge, Tianqing Liu, Xuehu Ma, Zhanfeng Cui
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2015)
Article
Chemistry, Multidisciplinary
Meiling Zhuang, Tianqing Liu, Dan Ge, Kedong Song, Shui Guan
Article
Biotechnology & Applied Microbiology
Shuping Wang, Shui Guan, Jing Wang, Hailong Liu, Tianqing Liu, Xuehu Ma, Zhanfeng Cui
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2017)
Article
Materials Science, Biomaterials
Shuping Wang, Shui Guan, Zhibo Zhu, Wenfang Li, Tianqing Liu, Xuehu Ma
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Chemistry, Multidisciplinary
Wei Zhang, Xudong Zuo, Ying Niu, Chengwei Wu, Shuping Wang, Shui Guan, S. Ravi P. Silva
Article
Materials Science, Biomaterials
Shuping Wang, Shui Guan, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma
BIOMATERIALS SCIENCE
(2017)
Article
Materials Science, Biomaterials
Shuping Wang, Changkai Sun, Shui Guan, Wenfang Li, Jianqiang Xu, Dan Ge, Meiling Zhuang, Tianqing Liu, Xuehu Ma
JOURNAL OF MATERIALS CHEMISTRY B
(2017)
Article
Biochemistry & Molecular Biology
Chao Xu, Shui Guan, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Xuehu Ma, Tianqing Liu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Materials Science, Biomaterials
Chao Xu, Shui Guan, Shuping Wang, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Kedong Song, Dan Ge, Shui Guan, Chenggong Sun, Xuehu Ma, Tianqing Liu
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2014)
Article
Materials Science, Biomaterials
Shuping Wang, Shui Guan, Wenfang Li, Dan Ge, Jianqiang Xu, Changkai Sun, Tianqing Liu, Xuehu Ma
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Ning Jin, Shouyu Zhang, Shibo Sun, Minghuo Wu, Xiaojing Yang, Jianqiang Xu, Kun Ma, Shui Guan, Weiping Xu
Summary: This study developed an efficient method for the recovery of ellagic acid from raspberry wine pomace. By using sodium bicarbonate assisted extraction, the yield of ellagic acid and its antioxidant activity were significantly improved.
Article
Biochemistry & Molecular Biology
Rui Yang, Shibo Sun, Yining Guo, Yao Meng, Haowen Liu, Meiyun Shi, Shui Guan, Jianqiang Xu
Summary: Macrophages secrete pro-inflammatory cytokines in response to pathogens, but abnormal release of cytokines can lead to cytokine storms. This study found that DMF can inhibit TXNRD1 and alleviate inflammation through activating NRF2. Targeting TXNRD1 may be a potential mechanism for immunometabolites to regulate inflammation.
Meeting Abstract
Cell & Tissue Engineering
S. Wang, S. Guan, T. Liu, X. Ma
TISSUE ENGINEERING PART A
(2017)
